Oral drug delivery system
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
1. A formulation comprising:
an opioid;
sucrose acetate isobutyrate (SAIB);
a cellulose acetate butyrate (CAB) having at least one feature selected from a butyryl content ranging from about 17% to about 38%, an acetyl content ranging from about 13% to about 30%, and a hydroxyl content ranging from about 0.8% to about 1.7%; and
a solvent.
2. The formulation of claim 1 , wherein the opioid comprises a member selected from buprenorphine, butorphanol, hydrocodone, hydromorphone, levorphanol, meperidine, methadone, morphine, oxycodone, oxymorphone, and tramadol, or a pharmacologically effective salt thereof.
3. The formulation of claim 1 , wherein the opioid is hydrocodone, hydromorphone, levorphanol, morphine, oxymorphone, or oxycodone.
4. The formulation of claim 1 , wherein the opioid comprises oxycodone.
5. The formulation of claim 1 , wherein the formulation comprises from about 20 weight percent to about 90 weight percent of the SAIB.
6. The formulation of claim 1 , wherein the formulation comprises from about 1 weight percent to about 8.6 weight percent of the CAB.
7. The formulation of claim 1 , wherein the formulation comprises from about 20 weight percent to about 50 weight percent of the solvent.
8. The formulation of claim 1 , wherein the solvent comprises propylene carbonate, N-methylpyrrolidone (NMP), glycofurol, alpha-tocopherol, diethyl phthalate, or polyethylene glycol 400 (PEG 400).
9. The formulation of claim 1 , wherein the solvent comprises triacetin or ethyl lactate.
10. The formulation of claim 1 , wherein the solvent comprises triacetin.
11. The formulation of claim 1 , further comprising a member selected from caprylic/capric triglyceride, isopropyl myristate (IPM), ethyl oleate, dimethyl phthalate, and benzyl benzoate.
12. The formulation of claim 1 , further comprising isopropyl myristate (IPM).
13. The formulation of claim 12 , wherein the formulation comprises from about 1 weight percent to about 75 weight percent of the IPM.
14. The formulation of claim 12 , wherein the formulation comprises:
from about 20 weight percent to about 90 weight percent of the SAIB;
from about 1 weight percent to about 8.6 weight percent of the CAB;
from about 1 weight percent to about 75 weight percent of the IPM; and
from about 20 weight percent to about 50 weight percent of the solvent.
15. The formulation of claim 14 , wherein the formulation comprises from 3 weight percent to 7.8 weight percent of the CAB.
16. The formulation of claim 14 , wherein the formulation comprises from 0.1 weight percent to 10 weight percent of the IPM.
17. The formulation of claim 14 , wherein the formulation comprises:
from about 30 weight percent to about 70 weight percent of the SAIB;
from about 1 weight percent to about 8.6 weight percent of the CAB;
from about 1 weight percent to about 75 weight percent of the IPM; and
from about 25 weight percent to about 48 weight percent of the solvent.
18. The formulation of claim 1 , further comprising an antioxidant.
19. The formulation of claim 1 , further comprising butylhydroxyl toluene.
20. The formulation of claim 1 , wherein the formulation is contained in a capsule.
21. The formulation of claim 20 , wherein the capsule comprises gelatin or hydroxyl propylmethyl cellulose.
22. The formulation of claim 20 , wherein the capsule comprises a hard capsule comprising gelatin or hydroxyl propylmethyl cellulose.
23. A method of providing pain relief to a subject in need thereof, the method comprising:
orally administering to the subject an effective amount of the formulation of claim 20 .
24. A method of providing pain relief to a subject in need thereof, the method comprising:
orally administering to the subject an effective amount of the formulation of claim 1 .
25. The formulation of claim 1 , wherein the opioid comprises oxycodone or a pharmacologically effective salt thereof.
26. The formulation of claim 1 , wherein the opioid comprises a salt of oxycodone.