Fibrinogen-based tissue adhesive containing an elastase inhibitor

1. A tissue adhesive for wound healing in a patient in need thereof consisting essentially of therapeutically effective amounts of fibrinogen, a leukocyte protease inhibitor, plasminogen, aprotinin and Factor XIII.

2. A tissue adhesive according to claim 1 , characterized in that the leukocyte protease inhibitor is provided as a leukocyte protease inhibitor fraction, in particular a granulocyte-derived leukocyte protease inhibitor fraction.

3. A tissue adhesive according to claim 1 , containing human proteins.

4. A tissue adhesive according to claim 1 , containing human blood proteins or plasma proteins.

5. A tissue adhesive according to claim 1 , wherein said leukocyte protease inhibitor is contained in an amount ratio of from 1:100 to 1:150,000 based on mg of fibrinogen.

6. A tissue adhesive according to claim 1 , wherein at least 10-6 U of leukocyte protease inhibitor are contained per g of fibrinogen.

7. The tissue adhesive according to claim 1 , wherein it contains plasminogen in an amount of at least 0.0001 mg/mg of fibrinogen.

8. A tissue adhesive according to claim 1 , wherein the Factor XIII is present in an amount of at least 0.001 U/mg of fibrinogen.

9. A tissue adhesive according to claim 1 , wherein it is free from kininogenic proteins.

10. A tissue adhesive according to claim 1 , which is a solution.

11. A tissue adhesive according to claim 10 , wherein the solution is deep-frozen.

12. A tissue adhesive according to claim 1 , which is in virus inactivated form.