Nucleic acids and proteins from
The invention provides proteins from group B streptococcus ( Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
1. An isolated or recombinant S. agalactiae polypeptide in substantially pure form comprising twelve or more consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
2. The isolated or recombinant S. agalactiae polypeptide of claim 1 wherein the polypeptide comprises 20 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
3. The isolated or recombinant S. agalactiae polypeptide of claim 1 wherein the polypeptide comprises 50 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
4. The isolated or recombinant S. agalactiae polypeptide of claim 1 wherein the polypeptide comprises 70 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
5. The isolated or recombinant S. agalactiae polypeptide of claim 1 wherein the polypeptide comprises 100 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
6. The isolated or recombinant S. agalactiae polypeptide of any of claim 1 , 2 , 3 , 4 , or 5 , wherein the polypeptide is a recombinant polypeptide.
7. The isolated or recombinant S. agalactiae polypeptide of any of claim 1 , 2 , 3 , 4 , or 5 , wherein the polypeptide is a purified polypeptide.
8. A composition comprising:
an isolated or recombinant S. agalactiae polypeptide in substantially pure form comprising twelve or more consecutive amino acids from the amino acid sequence SEQ ID NO:3744; and
an adjuvant.
9. The composition of claim 8 wherein the polypeptide comprises 20 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
10. The composition of claim 8 wherein the polypeptide comprises 50 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
11. The composition of claim 8 wherein the polypeptide comprises 70 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
12. The composition of claim 8 wherein the polypeptide comprises 100 consecutive amino acids from the amino acid sequence SEQ ID NO:3744.
13. The composition of claim 8 wherein the polypeptide is a recombinant polypeptide.
14. The composition of claim 8 , wherein the adjuvant comprises an aluminium salt.
15. The composition of claim 8 wherein the polypeptide is a purified polypeptide.
16. The composition of claim 14 wherein the aluminium salt is alum.
17. The composition of claim 16 wherein the polypeptide is a purified polypeptide.
18. The composition of claim 16 wherein the polypeptide is a recombinant polypeptide.
19. The composition of claim 14 wherein the polypeptide is a recombinant polypeptide.
20. The composition of claim 14 wherein the polypeptide is a purified polypeptide.
21. The composition of claim 8 , wherein the adjuvant comprises squalene, polyoxyethylene sorbitan monooleate, and sorbitan trioleate.
22. The composition of claim 21 wherein the polypeptide is a purified polypeptide.
23. The composition of claim 21 wherein the polypeptide is a recombinant polypeptide.
24. An isolated or recombinant S. agalactiae polypeptide in substantially pure form which comprises the amino acid sequence SEQ ID NO:3744.
25. The isolated or recombinant S. agalactiae polypeptide of claim 24 , wherein the polypeptide is a purified polypeptide.
26. The isolated or recombinant S. agalactiae polypeptide of claim 24 , wherein the polypeptide is a recombinant polypeptide.
27. A composition comprising:
an isolated or recombinant S. agalactiae polypeptide comprising the amino acid sequence SEQ ID NO:3744; and
an adjuvant.
28. The composition of claim 27 , wherein the polypeptide is a purified polypeptide.
29. The composition of claim 27 , wherein the polypeptide is a recombinant polypeptide.