Compositions for alleviating inflammation and oxidative stress in a mammal
An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed comprising Bacopa monniera extract; milk thistle extract, ashwagandha powder, green tea extract, Gotu kola powder, Ginko biloba leaf extract; Aloe vera powder; turmeric extract; and N-acetyl cysteine. The antioxidant-promoting composition of the invention safely induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side-effects associated with the individual components of the antioxidant-promoting composition. Also disclosed is a method for reducing the undesirable side-effects of free radicals in a subject by administering to a subject in need of such antioxidants an effective amount of antioxidant-promoting composition of the invention.
1. A composition comprising:
Bacopa monniera extract having a least 20 percent bacosides, wherein the Bacopa monniera extract is at least about 150 mg;
Silybum marianum (milk thistle) extract having 70 percent to about 80 percent silymarin, wherein the milk thistle extract is at least about 225 mg;
Withania somnifera (ashwagandha) extract;
Camellia sinensis (green tea) extract in an amount at least about 75 mg, wherein said green tea extract is comprised of at least 40 percent epigallocatechin gallate and about 98% polyphenols; and
Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of at least about 95 percent curcumin and wherein the turmeric extract is at least about 75 mg;
wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
2. The composition according to claim 1 wherein the composition is formulated as an oral dosage form.
3. The composition according to claim 2 , wherein the oral dosage form is selected from the group consisting of: a tablet; capsule; and caplet.
4. The composition according to claim 1 , further comprising one or more excipients selected from the group consisting of calcium carbonate; croscarmellose sodium; dicalcium phosphate; magnesium stearate; microcrystalline cellulose; modified cellulose; silica; and stearic acid.
5. A composition comprising:
about 22 weight percent Bacopa monniera extract comprised of about 45 percent bacosides; about 33 weight percent Silybum marianum (milk thistle) extract, wherein said milk thistle extract is comprised of between about 70 percent and about 80 percent silymarin; about 10 to 30 weight percent Withania somnifera ashwagandha extract; Camellia sinensis (green tea extract), wherein said green tea extract is comprised of 98 percent polyphenols; said polyphenols comprised of 45 percent (−)-epigallocatechin gallate; Curcuma longa (turmeric) extract; wherein said turmeric extract is comprised of about 95 percent curcumin; wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
6. The composition according to claim 5 , farther comprising one or more excipients selected from the group consisting of calcium carbonate; croscarmellose sodium; dicalcium phosphate; magnesium stearate; microcrystalline cellulose; modified cellulose; silica; and stearic acid.
7. A composition comprising, in an at least 675 mg formulation:
about 22 weight percent Bacopa monniera extract having 20 percent bacosides or greater;
about 22 weight percent Silybum marianum (milk thistle) extract having between about 70 percent and about 80 percent silymarin;
Withania somnifera (ashwagandha) extract;
about 11 weight percent Camellia sinensis (green tea) extract, wherein said green tea extract is comprised of at least about 45 percent epigallocatechin gallate and about 98% polyphenols; and
about 11 weight percent Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of at least about 95 percent curcumin;
wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
8. The composition according to claim 7 , wherein the composition is formulated as an oral dosage form.
9. The composition according to claim 8 , wherein the oral dosage form is selected from the group consisting of: a tablet; capsule; and caplet.
10. The composition according to claim 7 , further comprising one or more excipients selected from the group consisting of calcium carbonate; croscarmellose sodium; dicalcium phosphate; magnesium stearate; microcrystalline cellulose; modified cellulose; silica; and stearic acid.