IP Library › Granted Patent US 8,436,043
Granted Patent B2
US 8,436,043 · App. 12/920,973 · Granted May 7, 2013

Heterocyclic compound

Inventors: Yoshihiro Banno (Osaka, JP); Ryoma Hara (Osaka, JP); Ryosuke Tokunoh (Osaka, JP)
Assignee: Takeda Pharmaceutical Company Limited
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Quick Facts
Patent No.
US 8,436,043
App. No.
12/920,973
Granted
May 7, 2013
Kind
B2
Abstract

Provision of a prophylactic or therapeutic agent for diabetes, which has superior efficacy. A compound represented by the formula: wherein each symbol is as described in the specification, or a salt thereof.

Claims (23)

1. A compound represented by the following formula:

wherein ring AA is an optionally substituted benzene ring;

ring AB is an optionally substituted furan ring;

ring AC is an optionally substituted benzene ring;

R A3 is a C 1-6 alkyl group or a C 3-10 cycloalkyl group;

R A4 is a hydrogen atom or a C 1-6 alkyl group;

R A5 is NR A6 —CR A7 R A8 —CR A9 R A10 —COOR A11 ;

R A6 , R A7 , R A8 , R A9 and R A11 are each independently a hydrogen atom or a C 1-6 alkyl group; and

R A10 is a hydrogen atom, a C 1-6 alkyl group or a hydroxy group,

or a salt thereof.

2. The compound of claim 1 , wherein

R A4 is a hydrogen atom;

R A5 is NR A6 —(CH 2 ) 2 —COOR A11 ;

R A6 is a hydrogen atom or methyl; and

R A11 is a hydrogen atom, methyl or ethyl.

3. 3-{[(4-{[Cyclohexyl(3-methyl-1-benzofuran-2-yl)methyl]amino}phenyl)carbonyl](methyl)amino}propanoic acid or a salt thereof.

4. 3-{[(4-{[2-Ethyl-1-(5-fluoro-3-methyl-1-benzofuran-2-yl)butyl]amino}phenyl)carbonyl](methyl)amino}propanoic acid or a salt thereof.

5. 3-[{[4-({1-[5-(Cyclopropylmethoxy)-3-methyl-1-benzofuran-2-yl]-2-methylpropyl}amino)phenyl]carbonyl}(methyl)amino]propanoic acid or a salt thereof.

6. 3-[{[4-({Cyclohexyl[3-methyl-5-(tetrahydro-2H-pyran-4-yloxy)-1-benzofuran-2-yl]methyl}amino)phenyl]carbonyl}(methyl)amino]propanoic acid or a salt thereof.

7. A pharmaceutical composition comprising the compound of claim 1 or a salt thereof, and a pharmacologically acceptable carrier.

8. A method of suppressing sugar production in a mammal, comprising administering the compound of claim 1 or a salt thereof to the mammal.

9. A method for the prophylaxis or treatment of diabetes in a mammal, comprising administering the compound of claim 1 or a salt thereof to the mammal.

10. 3-{[(4-{[Cyclopentyl(5-fluoro-3-methyl-1-benzofuran-2-yl)methyl]amino}phenyl)carbonyl](methyl)amino}propanoic acid or a salt thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2010
From: BANNO, YOSHIHIRO; HARA, RYOMA; TOKUNOH, RYOSUKE
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 024938/0748 →
Priority Claims (2)
JP 2008-055250 · Mar 5, 2008 · national
JP 2009-025511 · Feb 6, 2009 · national
Continuity (2)
Related Publication 20120053173A1 · Mar 1, 2012
Related Publication 20120270865A2 · Oct 25, 2012