Composition of antigen and glycolipid adjuvant for sublingual administration
A method of producing a mucosal and systemic immune response in a mammal comprising administering sublingually an effective amount of a composition comprising at least one antigen and a glycolipid adjuvant to said mammal.
1. A method for producing a mucosal and systemic immune response in a human or animal comprising administering an effective amount of a composition comprising at least one antigen and a TH-1 inducing adjuvant selected from a monophosphoryl lipid and a 3-de-O-acylated monophosphoryl lipid at a sublingual site of the human or animal, wherein the mucosal immune response is an IgA response and the systemic immune response is a serum IgG response, wherein the at least one antigen is derived from a virus, bacterium, prion, neoplasm, autoantigen, animal, plant, recombinant or synthetic material.
2. A method of producing an IgA immune response in a human or animal comprising administering an effective amount of a composition comprising at least one antigen and a TH-1 inducing adjuvant selected from a monophosphoryl lipid and a 3-de-O-acylated monophosphoryl lipid at a sublingual site of the human or animal, wherein the IgA immune response is a mucosal immune response at a site distal from the site of administration, wherein the at least one antigen is derived from a virus, bacterium, prion, neoplasm, autoantigen, animal, plant, recombinant or synthetic material.
3. The method of claim 1 , wherein the IgA immune response is distal from the sublingual site of administration of the composition.
4. The method of claim 1 , wherein the composition additionally comprises a sublingually administrable diluent, excipient, or carrier.
5. The method of claim 1 , wherein the composition comprises an aqueous solution, a gel, a capsule, a lozenge, or a tablet.
6. The method of claim 2 , wherein the composition additionally comprises a sublingually administrable diluent, excipient, or carrier.
7. The method of claim 2 , wherein the composition comprises an aqueous solution, a gel, a capsule, a lozenge, or a tablet.