Retinoids and use thereof
The present invention provides new retinoid compounds and uses of the compounds in humans and animals for non-neoplastic dermal or inflammatory conditions or disorders.
1. A method for treating or lessening severity of a non-neoplastic skin condition or disorder in a patient having said skin condition or disorder by administering to said patient a compound, or a composition comprising the compound, wherein said compound having a chemical structure as shown in Formula IV:
2. The method of claim 1 wherein the skin condition or disorder is selected from dermatological afflictions associated with excessive skin sebum production, and/or cell differentiation and/or proliferation disorders, and/or keratinization disorders and/or skin pigmentation disorders, and/or skin inflammatory disorders.
3. The method of claim 2 wherein the skin condition or disorder is selected from the group consisting of acne vulgaris, psoriasis, actinic keratosis, rosacea, seborrheic dermatitis, actinic lentigines, eczema, warts, keratosis, xerosis, icthyosis, lichen, keratoderma, folliculitis, vitiligo and melasma.
4. The method of claim 2 wherein the skin condition is acne vulgaris.
5. The method of claim 2 wherein the skin condition is psoriasis.
6. The method of claim 2 wherein the skin condition is actinic keratosis.