Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.
1. An isolated human IgG protease cleavage site peptide consisting of an amino acid sequence of SEQ ID NO: 16.
2. The peptide of claim 1 conjugated to a carrier protein in a manner such that the C-terminus of the peptide is chemically bound to a carrier protein.
3. The peptide conjugate of claim 2 , wherein the carrier protein is selected from the group consisting of keyhole limpet hemocyanin (KLH) or serum albumin.
4. A vaccine composition comprising the human IgG cleavage site peptide of claim 1 in association with one or more pharmaceutically acceptable carriers or adjuvants.
5. The vaccine composition of claim 4 where the adjuvant is selected from the group consisting of alum, incomplete Freund's adjuvant, complete Freund's adjuvant or MF59.