Methods for characterizing and treating cognitive impairment in aging and disease
This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in particular be used to identify genes associated with, and compounds useful in treating, cognitive impairment in aging.
1. A method for treating cognitive impairment in a subject in need thereof, the method comprising the step of administering to the subject a GABA-A α5 receptor agonist in an amount sufficient to beneficially alter cognitive function in said subject in an amount sufficient to beneficially alter cognitive function in said subject.
2. The method according to claim 1 , wherein the subject is a human subject.
3. The method according to claim 1 or 2 , wherein the agonist is selected from the group consisting of 1-methyl-7-acetyleno-5-phenyl-1,3-dihydro-benzo[e]-1,4-diazepin-2-one; 6,6 dimethyl-3-(3-hydroxypropyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one; and 8-ethylthio-3-methyl-5-(1-oxidopyridin-2-yl)-3,4-dihydronaphthalen-1(2H)-one.