Perfluorocarbons for use in treating pruritus
The subject application provides a method of treating pruritus comprising administering to the skin of a subject afflicted with pruritus an amount of a perfluorocarbon effective to treat the pruritus. The subject application also provides a method of alleviating a symptom of psoriasis comprising administering to the skin of a subject afflicted with psoriasis an amount of a perfluorocarbon effective to alleviate the symptom of psoriasis. The subject application also provides a perfluorocarbon composition for use in treating a subject afflicted with pruritus or psoriasis. The subject application further provides a pharmaceutical composition comprising an amount of a perfluorocarbon for use in treating pruritus or psoriasis.
1. A method of treating pruritus comprising administering to the skin of a subject afflicted with pruritus an amount of a perfluorocarbon effective to treat the pruritus.
2. The method of claim 1 , wherein the pruritus is induced by histamine, a burn, an infection or hemodialysis.
3. The method of claim 1 , wherein the pruritus is a symptom of an inflammatory skin condition, xerosis, an insect bite, a dermatological allergic response, allergic dermatitis, allergic contact dermatitis, photodermatitis, hand dermatitis, miliaria rubra, eczema, atopic dermatitis or contact dermatitis.
4. The method of claim 3 , wherein the inflammatory skin condition is psoriasis or allergic vulvovaginitis.
5. The method of claim 1 , wherein the pruritus is anal pruritus, uremic pruritus or aquagenic pruritus.
6. A method of alleviating a symptom of psoriasis comprising administering to the skin of a subject afflicted with psoriasis an amount of a perfluorocarbon effective to alleviate the symptom of psoriasis.
7. The method of claim 6 , wherein the symptom is pruritus.
8. The method of claim 1 , wherein the molecular formula of the perfluorocarbon consists 9-12 carbon atoms.
9. The method of claim 1 , wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane) perfluoro-n-butylcyclohexane, perfluorodecalin, trimethyl perfluorodecalin, perfluoroisopropyldecalin, perfluoro-tripropylamine, perfluorotributylamine, perfluoro-methylcyclohexylpiperidine, perfluoro-octylbromide, perfluoro-decylbromide, perfluoro-dichlorooctane, perfluorohexane, dodecafluoropentane, or a mixture thereof.
10. The method of claim 9 , wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane) or perfluoro-n-butylcyclohexane.
11. The method of claim 1 , wherein the perfluorocarbon is in a perfluorocarbon gel or emulsion.
12. The method of claim 1 , wherein the subject is afflicted with edema, erythema or erythematous lesion.
13. The method of claim 1 , wherein the administration of the perfluorocarbon reduces subject-perceived itching.
14. The method of claim 1 , wherein the administration of the perfluorocarbon relieves the subject's pruritus for 3 hours or more.
15. The method of claim 1 , wherein the administration of the perfluorocarbon relieves the subject's pruritus within 1 minute of the administration.
16. The method of claim 1 , wherein the subject is human.
17. The method of claim 6 , wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane) or perfluoro-n-butylcyclohexane.
18. The method of claim 6 , wherein the perfluorocarbon is in a perfluorocarbon gel or emulsion.
19. The method of claim 7 , wherein the administration of the perfluorocarbon relieves the subject's pruritus for 3 hours or more.
20. The method of claim 7 , wherein the administration of the perfluorocarbon relieves the subject's pruritus within 1 minute of the administration.