IP Library › Granted Patent US 8,518,888
Granted Patent B2
US 8,518,888 · App. 12/578,946 · Granted Aug 27, 2013

Method of treatment of gastrointestinal-type cancer with antagonistic antibodies to IL-11R

Inventors: Brendan J. Jenkins (Viewbank, AU); Tracy Lynn Putoczki (North Melbourne, AU); Matthias Ernst (Brunswick West, AU); Andrew Jarnicki (Brunswick, AU); Brent McKenzie (Sunshine, AU)
Assignees: CSL Limited; Ludwig Institute for Cancer Research Ltd.
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Quick Facts
Patent No.
US 8,518,888
App. No.
12/578,946
Granted
Aug 27, 2013
Kind
B2
Abstract

The present invention relates generally to the field of cancer therapy. More particularly, the present invention provides a method for the treatment of gastrointestinal-type cancers and therapeutic agents useful for same.

Claims (6)

1. A method for the treatment of a gastrointestinal-type cancer in a subject, said method comprising administering to said subject an interleukin-11 receptor (IL-11R)-specific antagonostic antibody in an amount effective to treat said gastrointestinal-type cancer.

2. The method of claim 1 wherein the gastrointestinal-type cancer is gastric cancer or colorectal cancer.

3. The method of claim 1 wherein the amount of IL-11R-specific antibody is an amount that inhibits or reduces activation of STAT3 and/or STAT1.

4. The method of claim 1 wherein the subject is a human.

5. The method of claim 1 further comprising the administration of an anti-cancer agent.

6. The method of claim 1 further comprising radiation therapy or surgical ablation of cancer tissue.

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNORS AND ASSIGNEE ADDRESS PREVIOUSLY RECORDED ON REEL 024159 FRAME 0824. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Apr 21, 2010
From: JENKINS, BRENDAN J.; PUTOCZKI, TRACY LYNN; ERNST, MATTHIAS; JARNICKI, ANDREW; MCKENZIE, BRENT
To: CSL LIMITED; LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
Reel/Frame 024264/0009 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2010
From: PUTOCZKI, TRACY LYNN; ERNST, MATTHIAS; JARNICKI, ANDREW; MCKENZIE, BRENT
To: CSL LIMITED; LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
Reel/Frame 024159/0824 →
Continuity (2)
Provisional Application 61105179 · Oct 14, 2008
Related Publication 20100183544A1 · Jul 22, 2010