Medical compositions containing ghrelin
It is provided a pharmaceutical composition stably containing ghrelin or its derivative, which is an endogenous growth hormone secretagogue (GHS) to a growth hormone secretagogue-receptor (GHS-R), comprising a aqueous solution containing the ghrelins having pH range of 2 to 7, wherein the aqueous solution having pH range of 2 to 7 is a buffer solution, especially, glycine hydrochloride buffer, acetate buffer, citrate buffer, lactate buffer, phosphate buffer, citric acid-phosphate buffer, phosphate-acetate-borate buffer or phthalate buffer, and the concentration of the ghrelins in the solution is from 0.03 nmol/mL to 6 μmol/mL.
1. A method of improving the stability of ghrelin or its derivative in an aqueous solution comprising:
adjusting the pH of the solution to be in the range of from 3 to 6;
wherein said aqueous solution is suitable for pharmaceutical administration to a human.
2. The method of claim 1 , wherein the solution further comprises a pH adjuster or a buffer agent.
3. The method of claim 1 , wherein the solution further comprises a pH adjuster comprising hydrochloric acid, sulfuric acid, nitric acid, boric acid, carbonic acid, bicarbonic acid, gluconic acid, sodium hydroxide, potassium hydroxide, aqueous ammonia, citric acid, monoethanolamine, lactic acid, acetic acid, succinic acid, fumaric acid, maleic acid, phosphoric acid, methanesulfonic acid, malic acid, propionic acid, trifluoroacetic acid, a salt thereof, or a mixture thereof.
4. The method of claim 2 , wherein the solution further comprises a buffer agent comprising glycin, acetic acid, citric acid, boric acid, phthalic acid, phosphoric acid, succinic acid, lactic acid, tartaric acid, carbonic acid, hydrochloric acid, sodium hydroxide, a salt thereof, or a mixture thereof.
5. The method of claim 2 , wherein the concentration of the pH adjuster or the buffer agent in the solution ranges from 0.01 mM to 1,000 mM.
6. The method of claim 1 , wherein the solution comprises a buffer solution.
7. The method of claim 6 , wherein the buffer solution comprises glycine hydrochloride buffer, acetate buffer, citrate buffer, lactate buffer, phosphate buffer, citric acid-phosphate buffer, phosphate-acetate-borate buffer, phthalate buffer, or a mixture thereof.
8. The method of 1 , wherein the concentration of the ghrelin or its derivative in the solution ranges from 0.03 nmol/mL to 6 μmol/mL.
9. The method of claim 1 , wherein the ghrelin or its derivative is in the form of an acetic acid salt.
10. The method of claim 1 , wherein the ghrelin or its derivative comprises human ghrelin or its derivative.
11. The method of claim 1 , wherein the pH of the solution is adjusted to be in the range of 4 to 5.