IP Library › Granted Patent US 8,518,927
Granted Patent B2
US 8,518,927 · App. 13/148,658 · Granted Aug 27, 2013

Chemically programmed vaccination

Inventor: Carlos F. Barbas, III (La Jolla, CA)
Assignee: The Scripps Research Institute
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Quick Facts
Patent No.
US 8,518,927
App. No.
13/148,658
Granted
Aug 27, 2013
Kind
B2
Abstract

Provided herein is a method for chemically programmed vaccination. Methods include inducing a covalent-binding polyclonal antibody response in a subject and programming the polyclonal response with a targeting compound.

Claims (11)

1. The compound of formula V:

wherein R 1 is

and

wherein the Linker is:

—NHC(═O)(CH 2 ) 3 C(═O)NH—,

—NHC(═O)(CH 2 ) 3 C(═O)NH(CH 2 ) 3 —,

—NHC(═O)(CH 2 ) 3 C(═O)NH(CH 2 ) 2 (OCH 2 CH 2 ) 2 —,

—(CH 2 ) 3 NHC(═O)(CH 2 ) 3 C(═O)NH—,

—O(CH 2 CH 2 O) 3 (CH 2 ) 2 NHC(═O)(CH 2 ) 3 C(═O)NH—,

2. The compound of claim 1 , wherein the compound of formula V has formula:

wherein each n is independently an integer from 0 to 20.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 11, 2014
From: THE SCRIPPS RESEARCH INSTITUTE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032671/0099 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2011
From: BARBAS III, CARLOS F.
To: THE SCRIPPS RESEARCH INSTITUTE
Reel/Frame 026772/0330 →
Continuity (2)
Provisional Application 61151454 · Feb 10, 2009
Related Publication 20110311516A1 · Dec 22, 2011