Serial siphon valves for fluidic or microfluidic devices
Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.
1. A centripetal microfluidic device comprising:
a rotatable disk defining a platform having a circumference and a central hole for receiving an actuator for being rotated thereby; and
a microfluidic network formed in said platform comprising:
a longitudinal curved upstream dispensing chamber near said circumference;
a longitudinal curved downstream receiving chamber being radially outward relative to said upstream chamber; and
a serial siphon valve conduit interposed therebetween and comprising an inlet aperture in fluid communication with said dispensing chamber and an outlet aperture in fluid communication with said receiving chamber, said serial siphon valve conduit comprising a sinuous configuration between said inlet and outlet apertures defining a series of co-radial siphon valves separated by capillary valve structures, said series of co-radial siphon valves defining radially inward bends and radially outward bends, said capillary valve structures being respectively positioned at and contiguous with respective said bends thereby enlarging the spatial structure of said bends,
wherein when applying a centripetal force to said microfluidic network, a fluid within said network flows in the downstream direction, each said capillary valve structure configured for blocking fluid movement when the capillary force of said capillary valve structure overcomes the centripetal force.
2. A centripetal microfluidic device according to claim 1 , wherein said disk comprises an assembly of interfaced disk members.
3. A centripetal microfluidic device according to claim 1 , wherein said upstream chamber comprises a pair of opposite walls, one said wall being radially outward of the other said wall, said inlet being positioned near said radially outward wall.
4. A centripetal microfluidic device according to claim 1 , wherein said downstream chamber comprises a pair of opposite walls, one said wall being radially inward of the other said wall, said outlet being positioned near said radially inward wall.
5. A centripetal microfluidic device according to claim 1 , wherein said siphon valves are integral with said capillary valve structures.
6. A centripetal microfluidic device according to claim 1 , wherein a said siphon valve comprises a pair of adjacent canal branches, said bend interposed therebetween.
7. A centripetal microfluidic device according to claim 1 , wherein said bend is radially inward relative to said pair of canal branches.
8. A centripetal microfluidic device according to claim 1 , wherein said another bend is radially outward relative to said bend interposed between said adjacent canal branches.
9. A centripetal microfluidic device according to claim 1 , further comprising the actuator.
10. A centripetal microfluidic device according to claim 1 , wherein said radially inward bends are positioned generally along the same inner arc, said radially outward bends being positioned generally along the same outer arc, said outer arc being radially inwards relative to said downstream receiving chamber.
11. A centripetal microfluidic device according to claim 10 , wherein said inner arc is radially inwards relative to said upstream dispensing chamber.