Continuous emulsification method and emulsification apparatus therefor
The present invention relates to an emulsification method and an emulsification apparatus, capable of attaining easy control of particle size and particle size distribution, and simple scale-up and maintenance, and providing an emulsifying amount sufficient for industrial production. Namely, the method comprises continuously and successively passing two or more types of liquids which are substantially immiscible with each other through two or more mesh members disposed at certain intervals in the presence of an emulsifier to thereby perform emulsification, and the emulsification apparatus as an apparatus for carrying out the method comprises liquid feed pumps for feeding two or more types of liquids which are substantially immiscible with each other, and a cylindrical flow passage to which the two or more types of liquids are fed by the liquid feed pumps, the cylindrical flow passage including a predetermined number of wire gauzes disposed therein at a predetermined interval.
1. An emulsification method, comprising the step of continuously and successively passing two or more liquids which are substantially immiscible with each other through two or more mesh members disposed at an interval of 5 to 200 mm within a flow passage in the presence of an emulsifier, said step producing a narrow particle size distribution (CV value) of 35% or less, wherein CV value (%) =standard deviation of droplet diameter distribution/volume average particle size ×100.
2. The method according to claim 1 , wherein the number of the two or more mesh members to be disposed is 5 to 50.
3. The method according to claim 1 , wherein the mesh members have a fineness of mesh corresponding to mesh of Mesh No. 35 to 4000 specified in ASTM Standard.
4. The method according to claim 1 , wherein the mesh members have a multilayer structure.
5. An emulsification apparatus, comprising liquid feed pumps for feeding two or more types of liquids which are substantially immiscible with each other, and a cylindrical flow passage in which the two or more types of liquids fed by the liquid feed pumps are introduced through one end thereof, and passed toward the other end thereof, the cylindrical flow passage including two or more mesh members disposed therein at intervals of 5 to 200 mm, so that emulsification is performed by successively passing the liquids through the two or more mesh members and emulsion particles produced by the emulsion apparatus have a narrow particle size distribution (CV value) of 35% or less, wherein CV value (%) =standard deviation of droplet diameter distribution/volume average particle size ×100.
6. The emulsification apparatus according to claim 5 , wherein the number of the mesh members to be disposed is 5 to 50.
7. The emulsification apparatus according to claim 5 , wherein the mesh members have a fineness of mesh corresponding to mesh of Mesh No. 35 to 4000 specified in ASTM Standard.
8. The emulsification apparatus according to claim 5 , wherein the mesh members have a multilayer structure.
9. The emulsification apparatus according to claim 5 , wherein the mesh members are composed of wire gauze.
10. The emulsification apparatus according to claim 5 , wherein the liquid feed pumps are two or more pumps for independently feeding the two or more types of liquids, respectively.
11. The method according to claim 1 , wherein:
the number of the two or more mesh members to be disposed is 5 to 50;
the mesh members have a fineness of mesh corresponding to mesh of Mesh No. 35 to 4000 specified in ASTM Standard; and
the mesh members have a multilayer structure.
12. The method of claim 1 , wherein said interval allows the particle size to stabilize without coagulation.