Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
1. A method of forming a coating on an implantable medical device, comprising:
a) forming a coating comprising nano- or micro-particles of a drug in crystalline or partially crystalline form onto at least a portion of an implantable medical device, and
b) wrapping the implantable medical device on top of the coating comprising the nano- or micro-particles of the drug with a sheet of a polymer, wherein the polymer is poly(ethylene glycol terephthalate)-co-poly(butylene terephthalate); and
c) heating the sheet of the polymer at a temperature above the glass transition temperature of the polymer to form a coating comprising the polymer on top of the nano- or micro-particles of the drug.
2. The method of claim 1 , wherein the drug is selected from the group consisting of Zotarolimus, paclitaxel, docetaxel, tacrolimus, pimecrolimus, batimastat, mycophenolic acid, estradiol, clobetasol, dexamethasone, rapamycin, 40-0-(2-hydroxy)ethyl-rapamycin (everolimus), 40-0-(3-hydroxy)propyl-rapamycin, 40-0-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-0-tetrazole-rapamycin, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl(4-amino-TEMPO), and combinations thereof.
3. The method of claim 1 , wherein the crystallinity of the drug is selected from the group consisting of about 30%, about 40%, about 50%, about 60%, about 70%, about 75%, about 80%, about 90%, about 95%, about 99%, and about 100%.
4. The method of claim 1 , wherein the temperature above the glass transition temperature of the polymer to which the sheet is heated is also below the melting temperature of the drug.
5. The method of claim 1 , wherein the drug is everolimus.
6. The method of claim 4 , further comprising maintaining the polymer at a temperature above the glass transition temperature of the polymer and below the melting temperature of the drug such that drug crystallites initiate and grow.
7. The method of claim 4 , further comprising maintaining the polymer at a temperature above the glass transition temperature of the polymer and below the melting temperature of the drug to increase the crystallinity of the drug.