IP Library › Granted Patent US 8,551,772
Granted Patent B2
US 8,551,772 · App. 13/302,081 · Granted Oct 8, 2013

Detection of mutations in a gene associated with resistance to viral infection, OAS1

Inventors: Shawn P Iadonato (Seattle, WA); Charles L Magness (Seattle, WA); Gary Rosenberg (Danbury, CT); Christina A Scherer (Seattle, WA); Thierry Guillaudeux (Rennes, FR)
Assignee: Kineta Two, LLC
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Quick Facts
Patent No.
US 8,551,772
App. No.
13/302,081
Granted
Oct 8, 2013
Kind
B2
Abstract

A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.

Claims (1)

1. An isolated expression vector comprising a polynucleotide consisting of a nucleotide sequence that encodes a polypeptide, wherein the encoded polypeptide consists of the sequence of SEQ ID NO:48.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2013
From: GUILLAUDEUX, THIERRY
To: ILLUMIGEN BIOSCIENCES, INC.
Reel/Frame 031111/0747 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2013
From: IADONATO, SHAWN P; MAGNESS, CHARLES L; ROSENBERG, GARY; SCHERER, CHRISTINA A
To: ILLUMIGEN BIOSCIENCES, INC.
Reel/Frame 031111/0832 →
MERGER Recorded Aug 29, 2013
From: IB SECURITYHOLDERS, LLC
To: KINETA TWO, LLC
Reel/Frame 031112/0089 →
ASSET TRANSFER AGREEMENT Recorded Aug 29, 2013
From: ILLUMIGEN BIOSCIENCES, INC.
To: IB SECURITYHOLDERS, LLC
Reel/Frame 031123/0581 →
Continuity (10)
Continuation 12061548 · Apr 2, 2008
Continuation 10972135 · Oct 22, 2004
Provisional Application 60513888 · Oct 23, 2003
Provisional Application 60542373 · Feb 6, 2004
Provisional Application 60554758 · Mar 19, 2004
Provisional Application 60560524 · Apr 8, 2004
Provisional Application 60578323 · Jun 9, 2004
Provisional Application 60583503 · Jun 28, 2004
Provisional Application 60605243 · Aug 26, 2004
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