Activators of pyruvate kinase M2 and methods of treating disease
The invention described herein features methods, compositions, and kits for the use of activators of PKM2 for the treatment, prevention, or amelioration of diseases related to PKM2 function, including, e.g., cancer, diabetes, atherosclerosis, restenosis, obesity, autoimmune disorders, and proliferative disorders.
1. A method of treating a patient suffering from lung cancer, said method comprising administering to said patient in need thereof a pharmaceutical composition comprising an effective amount of a compound selected from
or a salt thereof, wherein said compound is administered to said patient in the absence of therapeutic levels of a hypoxic sensitizer in said patient; and further comprising administering to said patient cisplatinum to thereby treat said patient.
2. The method of claim 1 , further comprising the step of identifying said patient to treat on the basis of PKM2 activity in said patient.
3. The method of claim 1 or 2 , wherein said compound selectively activates PKM2.
4. The method of claim 1 , wherein the compound is
or a salt thereof.