Secreted/cell bound poxvirus proteins and methods of use thereof as vaccines and anti-viral agents
Compositions and methods for the treatment and prevention of pox virus infections are disclosed.
1. A pharmaceutical composition comprising a humanized isolated antibody or functional fragment thereof immunologically specific for a viral interferon α/β binding protein, contained in a pharmaceutically acceptable carrier suitable for passive immunization into a human subject, said antibody cross reacting with and blocking the activity of an interferon α/β binding protein from a pox virus selected from the group consisting of monkey pox virus (MPXV), variola virus (VARV) and ectromelia virus (ECTV).
2. A method for passively immunizing a subject against pox infection comprising administering an effective amount of the composition of claim 1 to a subject in need thereof, said administration being effective to treat or attenuate said pox infection.
3. The method of claim 2 , wherein said pox infection is selected from the group consisting of small pox infection and monkey pox infection, said method optionally comprising administration of an anti-viral agent.