Polyalkylene glycol derivative and process for producing same
A process for producing a polyalkylene glycol derivative having such high molecular weight and purity that the derivative can be used in pharmaceutical applications, which produces a polyalkylene glycol derivative of the formula (X) by steps (A), (B), (C) and (D), wherein R is as defined: R—(OA) n OH (X) (step (A)) 5 to 50% by mol of an alkali catalyst is added to a compound represented by the formula (Y), wherein R is as defined: R—OH (Y) (step (B)) an alkylene oxide having 2 to 4 carbon atoms is reacted under a condition of 50 to 130° C. until the average number of moles of an oxyalkylene group OA added reaches the range of 5 to 500 to obtain a polyalkylene glycol derivative; (step (C)) 10 to 5000% by mass of a hydrocarbon solvent is added to the derivative of the step (B) to dilute it, and remaining water is removed by azeotropy; and (step (D)) the derivative of the step (B) is reacted with an alkylene oxide having 2 to 4 carbon atoms under a condition of 50 to 130° C. until the average number of moles of the oxyalkylene group (OA) reaches the range of 600 to 2000.
1. A process for producing a polyalkylene glycol derivative of the formula (X):
R—(OA) n OH (X)
wherein R represents a hydrocarbon group having 1 to 7 carbon atoms, a protective group of a hydroxyl group, a protective group of an amino group, a protective group of an aldehyde group, a protective group of a carboxyl group or a protective group of a mercapto group; OA is an oxyalkylene group having 2 to 4 carbon atoms; and n is an average number of moles of the oxyalkylene group added and is 600 to 2000,
the process comprising the following steps (A), (B), (C) and (D):
Step (A): a step of adding 5 to 50% by mol of an alkali catalyst to a compound represented by the formula (Y):
R—OH (Y)
wherein R represents a hydrocarbon group having 1 to 7 carbon atoms, a protective group of a hydroxyl group, a protective group of an amino group, a protective group of an aldehyde group, a protective group of a carboxyl group or a protective group of a mercapto group,
Step (B): a step of reacting an alkylene oxide having 2 to 4 carbon atoms under a condition of 50 to 130° C. until an average number of moles of the oxyalkylene group OA added reaches a range of 5 to 500 to obtain a polyalkylene glycol derivative,
Step (C): a step of adding 10 to 5000% by mass of a hydrocarbon solvent to the polyalkylene glycol derivative of the step (B) to dilute it and removing remaining water by azeotropy, and
Step (D): a step of reacting an alkylene oxide having 2 to 4 carbon atoms with the polyalkylene glycol derivative of the step (B) under a condition of 50 to 130° C. until an average number of moles of the oxyalkylene group OA added reaches a range of 600 to 2000.
2. The process according to claim 1 , wherein the oxyalkylene group is an oxyethylene group.
3. The process according to claim 1 , wherein n in the formula (X) is 900 to 2000.
4. The process according to claim 1 , wherein R in the formula (X) is a hydrocarbon group having 1 to 7 carbon atoms.
5. The process according to claim 4 , wherein R in the formula (X) is a methyl group.
6. The process according to claim 1 , wherein R in the formula (X) is a protective group of a hydroxyl group, a protective group of an amino group, a protective group of an aldehyde group, a protective group of a carboxyl group, or a protective group of a mercapto group.
7. The process according to claim 2 , wherein n in the formula (X) is 900 to 2000.
8. The process according to claim 2 , wherein R in the formula (X) is a hydrocarbon group having 1 to 7 carbon atoms.
9. The process according to claim 3 , wherein R in the formula (X) is a hydrocarbon group having 1 to 7 carbon atoms.
10. The process according to claim 7 , wherein R in the formula (X) is a hydrocarbon group having 1 to 7 carbon atoms.
11. The process according to claim 8 , wherein R in the formula (X) is a methyl group.
12. The process according to claim 9 , wherein R in the formula (X) is a methyl group.
13. The process according to claim 10 , wherein R in the formula (X) is a methyl group.
14. The process according to claim 2 , wherein R in the formula (X) is a protective group of a hydroxyl group, a protective group of an amino group, a protective group of an aldehyde group, a protective group of a carboxyl group, or a protective group of a mercapto group.
15. The process according to claim 3 , wherein R in the formula (X) is a protective group of a hydroxyl group, a protective group of an amino group, a protective group of an aldehyde group, a protective group of a carboxyl group, or a protective group of a mercapto group.
16. The process according to claim 7 , wherein R in the formula (X) is a protective group of a hydroxyl group, a protective group of an amino group, a protective group of an aldehyde group, a protective group of a carboxyl group, or a protective group of a mercapto group.