IP Library › Granted Patent US 8,580,954
Granted Patent B2
US 8,580,954 · App. 11/689,931 · Granted Nov 12, 2013

Formulations of low dose diclofenac and beta-cyclodextrin

Inventors: Curtis Wright (Rockport, MA); Daniel B. Carr (Chestnut Hill, MA); Fred H. Mermelstein (Newton, MA)
Assignee: Hospira, Inc.
C07H15/04C07H3/06C08B37/0015
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Quick Facts
Patent No.
US 8,580,954
App. No.
11/689,931
Granted
Nov 12, 2013
Kind
B2
Abstract

The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 10 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention.

Claims (22)

1. A method for treating a mammal in need of analgesia, comprising administering a pharmaceutical composition comprising:

(a) a unit dose of diclofenac sodium effective to induce analgesia; and

(b) a beta-cyclodextrin compound;

(c) a stabilizer;

wherein the unit dose of the diclofenac sodium is between about 3.75 mg to about 9.4 mg; and

wherein the pharmaceutical composition is formulated for parenteral administration.

2. A method for treating a mammal in need of analgesia, comprising administering a pharmaceutical composition comprising:

(a) a unit dose of diclofenac sodium effective to induce analgesia;

(b) a beta-cyclodextrin compound; and

(c) a stabilizer; wherein the unit dose of the diclofenac sodium is less than about 5 mg; and wherein the pharmaceutical composition is administered parenterally, wherein parenteral administration refers to intravenous administration or intramuscular administration.

3. A method for treating a mammal in need of analgesia, comprising administering a pharmaceutical composition to the mammal in need thereof, wherein the pharmaceutical composition comprises:

(a) a unit dose of diclofenac sodium effective to induce analgesia; and

(b) a beta-cyclodextrin compound;

(c) a stabilizer;

wherein the unit dose of the diclofenac sodium is less than 10 mg; and

wherein the pharmaceutical composition is administered intravenously.

4. A method for treating a mammal in need of analgesia, comprising administering a pharmaceutical composition to the mammal in need thereof, wherein the pharmaceutical composition comprises:

(a) a unit dose of diclofenac sodium effective to induce analgesia; and

(b) a beta-cyclodextrin compound;

(c) a stabilizer;

wherein the dose of the diclofenac sodium is less than 5 mg (+/−20%); and

wherein the pharmaceutical composition is administered intravenously.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 10, 2017
From: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
To: JAVELIN PHARMACEUTICALS, INC.
Reel/Frame 041538/0870 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 10, 2017
From: WRIGHT, CURTIS; CARR, DANIEL B.; MERMELSTEIN, FRED H.
To: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
Reel/Frame 041538/0582 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 15, 2013
From: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
To: JAVELIN PHARMACEUTICALS, INC.
Reel/Frame 031616/0163 →
SECURITY AGREEMENT Recorded Apr 20, 2010
From: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
To: HOSPIRA, INC.
Reel/Frame 024252/0650 →
RELEASE OF SECURITY INTEREST Recorded Apr 20, 2010
From: MYRIAD PHARMACEUTICALS, INC.
To: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
Reel/Frame 024252/0658 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NATURE OF CONVEYANCE IDENTIFIED IN THE RECORDATION OF SECURITY AGREEMENT PREVIOUSLY RECORDED ON REEL 023698 FRAME 0285. ASSIGNOR(S) HEREBY CONFIRMS THE GRANT OF A SECURITY INTEREST IN ITS TITLE AND INTEREST IN PATENT APPLICATIONS/PATENT IDENTIFIED IN THE AGREEMENT. Recorded Apr 9, 2010
From: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
To: MYRIAD PHARMACEUTICALS, INC.
Reel/Frame 024211/0088 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 23, 2009
From: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
To: MYRIAD PHARMACEUTICALS, INC.
Reel/Frame 023698/0285 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2007
From: WRIGHT, CURTIS; CARR, DANIEL B.; MERMELSTEIN, FRED H.
To: INNOVATIVE DRUG DELIVERY SYSTEMS, INC.
Reel/Frame 019289/0137 →
Continuity (2)
Provisional Application 60786486 · Mar 28, 2006
Related Publication 20070232566A1 · Oct 4, 2007