IP Library Granted Patent US 8,609,618
Granted Patent B2
US 8,609,618 · App. 13/072,277 · Granted Dec 17, 2013

Topical palmitoyl glutathione formulations

Inventor: Nicholas V. Perricone (Meriden, CT)
Assignee: N.V. Perricone LLC
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Quick Facts
Patent No.
US 8,609,618
App. No.
13/072,277
Granted
Dec 17, 2013
Kind
B2
Abstract

A topical composition for application to aging skin, comprising an effective amount of S-acyl glutathione derivative of formula (I) wherein R 1 consists of an unsaturated or saturated C 16 group and R 2 is a hydrogen, aliphatic or aromatic acyl group; and a dermatologically acceptable carrier. Preferred compositions comprise about 1.0% to about 3.0% by weight of S-palmitoyl glutathione.

Claims (17)

1. A topical composition for application to aging skin, comprising:

about 0.1% to about 5% by weight of S-palmitoyl glutathione of formula (I)

and a dermatologically acceptable water-based carrier.

2. The topical composition of claim 1 , wherein the S-palmitoyl glutathione is present from about 1.0% to about 3.0% by weight.

3. The topical composition of claim 1 , further comprising one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives, lipoic acid, neuropeptides, α-hydroxy acids, salts of magnesium, zinc and copper, tocotrienols, tocotrienol derivatives, and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives, and mixtures thereof.

4. The topical composition of claim 1 , wherein the composition comprises a cream.

5. A topical composition for application to aging skin comprising:

about 1.0% to about 3.0% by weight of S-palmitoyl glutathione;

about 1.5% to about 15% by weight of at least one fatty acid derivative of stearic acid;

about 1.0% to 5.0% by weight of isopropyl palmitate; and

water.

6. The topical composition of claim 1 , wherein carrier comprises an oil in water emulsion.

7. The topical composition of claim 6 , wherein the carrier comprises fatty acid derivatives of stearic acid and water.

8. A topical composition for application to aging skin, comprising:

about 0.1% to about 5% by weight of S-palmitoyl glutathione of formula (I)

and a dermatologically acceptable oil in water emulsion.

9. The topical composition of claim 8 , wherein the oil in water emulsion comprises fatty acid derivatives of stearic acid and water.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Jun 5, 2015
From: MUFG UNION BANK, N.A., AS AGENT FORMERLY KNOWN AS UNION BANK, N.A., AS AGENT
To: N.V. PERRICONE LLC
Reel/Frame 035794/0978 →
SECURITY INTEREST Recorded Jun 5, 2015
From: N.V. PERRICONE LLC
To: THE NORTHWESTERN MUTUAL LIFE INSURANCE COMPANY, AS ADMINISTRATIVE AGENT
Reel/Frame 035833/0948 →
SECURITY INTEREST Recorded Jun 2, 2014
From: N.V. PERRICONE LLC
To: UNION BANK, N.A., AS ADMINISTRATIVE AGENT FOR THE LENDERS
Reel/Frame 033075/0393 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2011
From: PERRICONE, NICHOLAS V.
To: N.V. PERRICONE LLC
Reel/Frame 026626/0309 →
Continuity (1)
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