Treatment for pulmonary hypertension
One embodiment relates to a method of treating pulmonary hypertension based upon co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension. The benefit of the co-administration of these agents is to eliminate or reduce one or more side effects associated with mono-therapy of either agent, as well as one or more side effects associated with other administration routes such as subcutaneous or intravenous administration.
1. A method of treating pulmonary hypertension comprising co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension, wherein the oral therapeutic agent is treprostinil or a pharmaceutically acceptable salt or ester thereof and wherein the inhaled therapeutic agent is treprostinil or a pharmaceutically acceptable salt or ester thereof.
2. The method of claim 1 , wherein the subject is a human being.
3. The method of claim 2 , wherein the co-administration delays the time to initiation of parenteral therapy for pulmonary hypertension in comparison to therapy with either an oral or inhaled therapeutic agent for pulmonary hypertension used alone.
4. The method of claim 1 , wherein the oral therapeutic agent is the diethanolamine salt of treprostinil and the inhaled therapeutic agent is the sodium salt of treprostinil.