IP Library › Granted Patent US 8,614,192
Granted Patent B2
US 8,614,192 · App. 12/373,308 · Granted Dec 24, 2013

Method for treating ocular cancer

Inventors: Michael A. Dyer (Memphis, TN); Jean-Christophe Marine (Erbisoeul, BE); Aart Gerrit Jochemsen (Leiden, NL)
Assignees: Leiden University Medical Center; Flanders Interuniversity Institute for Biotechnology, VIB; St. Jude Children's Research Hospital
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Quick Facts
Patent No.
US 8,614,192
App. No.
12/373,308
Granted
Dec 24, 2013
Kind
B2
Abstract

It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53 activator. In particular embodiments, the p53 activator blocks the interaction between DM2 or DMX and p53. As the p53 activator induces ocular cancer cell death, a method for preventing or treating ocular cancer is also provided.

Claims (2)

1. A method for treating retinoblastoma comprising administering to a subject in need of treatment an effective amount of a cis-imidazoline thereby treating the subject's retinoblastoma.

2. A method for treating retinoblastoma comprising administering to a subject in need of treatment an effective amount of a compound that blocks an interaction between p53 and DMX, thereby treating the subject's retinoblastoma.

Assignments (5)
CONFIRMATORY LICENSE Recorded Mar 14, 2018
From: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 045583/0989 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2009
From: MARINE, JEAN-CHRISTOPHE
To: FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY, VIB; UNIVERSITEIT GENT
Reel/Frame 023257/0063 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2009
From: DYER, MICHAEL A.
To: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Reel/Frame 022593/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2009
From: MARINE, JEAN-CHRISTOPHE
To: FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY, VIB
Reel/Frame 022593/0558 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2009
From: JOCHEMSEN, AART GERRIT
To: LEIDEN UNIVERSITY MEDICAL CENTER
Reel/Frame 022593/0593 →
Continuity (2)
Provisional Application 60820652 · Jul 28, 2006
Related Publication 20090298785A1 · Dec 3, 2009