4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
1. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is aryl, optionally substituted with one, two or three groups selected from alkyl, halo, alkoxy,
carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy,
alkylaminocarboxy, and alkylsulfonyl; and
n 1 is 0-5.
2. The compound of claim 1 , wherein Y is CH 2 .
3. The compound of claim 1 , wherein Y is C═O.
4. The compound of claim 1 , wherein the aryl is phenyl.
5. The compound of claim 1 , wherein the aryl is naphthyl.
6. The compound of claim 4 , wherein the phenyl is substituted with halo.
7. The compound of claim 5 , wherein the naphthyl is substituted with halo.
8. The compound of claim 4 , wherein the phenyl is substituted with alkyl or alkoxy.
9. The compound of claim 5 , wherein the naphthyl is substituted with alkyl or alkoxy.
10. The compound of claim 1 , which is:
11. The compound of claim 1 , which is: