Combined electrical and optical sensor for fluids
The present invention relates to a sensor for the detection of an analyte, comprising a fluid holder ( 8 ), an optical detection system ( 3, 9 ) for carrying out an optical detection at the fluid holder ( 8 ) and an electrical detection system ( 4 ) for measuring electric conductivity or resistance inside the fluid holder ( 8 ) and to a method comprising the use of such a sensor.
1. Sensor for the detection of an analyte, comprising a fluid holder, an optical detection system for carrying out an optical detection at the fluid holder and an electrical detection system for measuring electric conductivity or resistance inside the fluid holder, wherein the sensor is provided with a controller for regulating the electrical detection system, dependent on the detection signal originating from the optical detection system and/or for regulating the optical detection system, dependent on the detection signal originating from the electrical detection system.
2. Sensor according to claim 1 , wherein the electrical detection system comprises at least two electrodes, which are at least prior to use spatially apart, for measuring the electric conductivity or resistance.
3. Sensor according to claim 2 , wherein a probe for an analyte of interest is present between two electrodes of the electrical detection system.
4. Sensor according to claim 2 , wherein the electrodes are arranged such that at least when using the sensor to detect an analyte—the space between the electrodes is at an angle of 45°-135°, with the light path of the optical detection system.
5. Sensor according to claim 1 , wherein the sensor comprises a fluid holder, defining a plurality of detection cells, of which at least a number are each provided with: at least two electrodes for measuring electric conductivity or resistance in the detection cell provided with said electrodes, a light-source and an optical detection unit, the sensor further comprising a read-out system, which can hold the fluid holder, the read out system comprising an electric conductivity or resistance meter for measuring the conductivity or resistance (in the gap) between two electrodes of a detection cell and a connector for electrically conductively connecting the meter with the electrodes, the read-out system further comprising a module for measuring the output of the optical detection unit.
6. Sensor according to claim 1 , wherein the sensor is a micro-structured device.
7. Sensor according to claim 5 , wherein the light source comprises a LED.
8. Sensor according to claim 5 , wherein the optical detection unit comprises a photodiode.
9. Sensor according to claim 1 , wherein the controller is configured to regulate the electrical detection system dependent on the detection signal from the optical detection signal, and wherein the optical detection signal that regulates the electrical detection system is the detection signal that indicates a percolation threshold.