PAI-1 inhibitor
The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: R 1 represents a C 6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 or 1; when m is 0, G represents —N—C(═O)—CO 2 H or the like; when m is 1, G represents an oxygen atom or the like; R 2 represents a C 6-10 aryl group which may be substituted or the like; E represents the following formula (II) wherein one of R 31 , R 32 , R 33 and R 34 represents the formula R 1 -T-, each of the other three independently represents a hydrogen atom or the like, and R 35 represents the formula —X—Y′, a hydrogen atom or the like; X represents —CH 2 — or the like; Y′ represents a carboxy group or the like; M represents a single bond or the like.
1. A compound represented by the following formula (I) or a salt thereof:
wherein:
m represents 1;
E represents the following formula (II):
wherein
R 35 represents the formula —X—Y′; and
one of R 31 , R 32 , R 33 and R 34 represents the formula R 1 -T-, and each of the other three independently represents a hydrogen atom or a group selected from the following substituent group γ-1;
R 1 represents a C 6-10 aryl group or a C 6-10 aryl group substituted with one to five groups selected from the following substituent group α-1, wherein, when the number of the substituents is two or more, each of the substituents may be the same or different;
T represents a single bond or —O—;
G represents an oxygen atom;
R 2 represents a C 6-10 aryl group or a C 6-10 aryl group substituted with one to five groups selected from the following substituent group β-1, wherein, when the number of the substituents is two or more, each of the substituents may be the same or different;
X represents —CH═CH—, or —CH 2 CH 2 —;
Y′ represents a carboxy group; and
M represents a single bond, or the formula —Z 2 —O— wherein, the bond at the left-hand end binds to G, and the bond at the right-hand end binds to R 2 in each of the formulas; and
Z 2 represents a C 1-9 straight chain alkylene group; provided that:
when R 33 is the formula R 1 -T-; each of R 31 , R 32 and R 34 is a hydrogen atom; R 1 is a C 6-10 aryl group or a C 6-10 aryl group substituted with a group or groups selected from a halogen atom, a nitro group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group, a C 1-6 alkylsulfanyl group, an amino group and a C 1-6 alkylenedioxy group; R 2 is a C 6-10 aryl group or a C 6-10 aryl group substituted with a group or groups selected from a halogen atom, a nitro group, a C 1-6 alkroup, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group, a phenyl group and a carboxy group; and M is a single bond; then T represents is —O—;
[substituent group α-1]
a halogen atom, a cyano group, a nitro group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group, a C 1-6 alkylsulfanyl group, an amino group and a C 1-6 alkylenedioxy group;
[substituent group β-1]
a halogen atom, a nitro group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group, a C 1-6 alkylsulfanyl group, a phenyl group and a carboxy group;
[substituent group γ-1]
a halogen atom, a C 1-6 alkyl group and a C 1-6 alkoxy group.
2. A medicament comprising the compound according to claim 1 or a pharmacologically acceptable salt thereof.
3. The compound or the salt thereof according to claim 1 , wherein one of R 31 , R 32 , R 33 and R 34 is the formula R 1 -T-, and each of the other three is a hydrogen atom.
4. The compound or the salt thereof according to claim 3 , wherein R 32 is the formula R 1 -T-.
5. The compound or the salt thereof according to claim 1 , wherein R 1 is a phenyl group substituted with one or two groups selected from the substituent group α-1.
6. The compound or the salt thereof according to claim 1 , wherein R 1 is a phenyl group substituted with a group selected from a C 1-6 alkyl group, a C 1-6 alkoxy group, and a halogenated C 1-6 alkoxy group.
7. The compound or the salt thereof according to claim 1 , wherein R 1 is a phenyl group substituted with a halogenated C 1-6 alkoxy group.
8. The compound or the salt thereof according to claim 1 , wherein R 1 is a group selected from the group consisting of:
9. The compound or the salt thereof according to claim 1 , wherein T is a single bond.
10. The compound or the salt thereof according to claim 1 , wherein R 2 is a phenyl group substituted with one or two groups selected from the substituent group β-1.
11. The compound or the salt thereof according to claim 1 , wherein R 2 is a phenyl group substituted with a group selected from a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, and a halogenated C 1-6 alkoxy group.
12. The compound or the salt thereof according to claim 1 , wherein R 2 is a group selected from the group consisting of:
13. The compound or the salt thereof according to claim 1 , wherein X is —CH 2 CH 2 —.
14. The compound or the salt thereof according to claim 1 , wherein M is a single bond.
15. The compound or the salt thereof according to claim 1 , wherein the compound is selected from the group consisting of:
16. The compound or the salt thereof according to claim 15 , wherein the compound is selected from the group consisting of:
17. The compound or salt thereof according to claim 15 , wherein, the compound is selected from the group consisting of:
18. The compound or the salt thereof according to claim 15 , wherein the compound is selected from the group consisting of:
19. The compound or salt thereof according to claim 15 , wherein the compound is selected from the group consisting of:
20. The compound or the salt thereof according to claim 15 , wherein, the compound is selected from the group consisting of: