Parenteral selenomethionine for production of selenium-rich foods
A formulation for parenteral administration which includes selenomethionine and at least one oil-based vehicle. The formulation is used for elevating the selenium levels in the blood, milk and/or meat of an animal. These products (i.e. milk and meat) and the formulation itself are used to meet the selenium nutritional requirement for growth and health in a selenium deficient animal.
1. A veterinary formulation for injectable administration which includes:
selenomethionine; and,
at least one oil-based vehicle;
wherein the concentration of selenomethionine ranges from 25 to 100 g/L;
wherein the oil-based vehicle comprises arachis oil or an oil that has equivalent properties of viscosity and temperature stability to arachis oil; and
wherein the formulation is suitable for subcutaneous or intramuscular injection and forms a depot on administration.
2. The formulation as claimed in claim 1 , wherein the selenomethionine chemical structure has the following formula, representing the D and L enantiomer forms or their racemic mixture:
3. The formulation as claimed in claim 1 , wherein the selenomethionine is in micronised particulate form.
4. The formulation as claimed in claim 1 , wherein the selenomethionine form is a distribution of particle sizes from approximately 0.1 to 10 μm.
5. The formulation as claimed in claim 1 , wherein the oil-based vehicle or vehicles are characterised by being non-allergenic, thin and flowing at room temperature and slow to deteriorate by oxidation.
6. A formulation as claimed in claim 1 , wherein the formulation also includes a suspending agent.
7. A formulation as claimed in claim 6 , wherein the suspending agent is beeswax.
8. A formulation as claimed in claim 7 , wherein the beeswax is white beeswax.
9. A formulation as claimed in claim 6 , wherein the beeswax is added in a concentration ranging from approximately 5 to 50 g/L.
10. A formulation as claimed in claim 7 , wherein the beeswax is added in a concentration is approximately 15 g/L.
11. A formulation as claimed in claim 6 , wherein the suspending agent is of a pharmaceutical grade.
12. A formulation as claimed in claim 6 , wherein sufficient suspending agent is added to the formulation so that the formulation has a resulting density of approximately 0.92 g/ml when measured at 23° C.