IP Library › Granted Patent US 8,637,541
Granted Patent B2
US 8,637,541 · App. 13/120,076 · Granted Jan 28, 2014

Indole derivatives as CRTH2 receptor antagonists

Inventor: Zhaoyin Wang (Kirkland, CA)
Assignee: Merck Canada Inc.
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Quick Facts
Patent No.
US 8,637,541
App. No.
13/120,076
Granted
Jan 28, 2014
Kind
B2
Abstract

The compound (+) {7R-[[(4-fluorophenyl)sulfonyl] (methyl)ammo]-6,7,8,9-tetrahydropyrido[1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts thereof are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-meidated diseases such as asthma.

Claims (2)

1. The compound (+) {7R-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-α]indol-10-yl }acetic acid or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

Assignments (2)
CHANGE OF NAME Recorded Jan 25, 2013
From: MERCK FROSST CANADA LTD.
To: MERCK CANADA INC.
Reel/Frame 029695/0522 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2013
From: WANG, ZHAOYIN
To: MERCK FROSST CANADA LTD.
Reel/Frame 029619/0816 →
Continuity (3)
Provisional Application 61192786 · Sep 22, 2008
Provisional Application 61109263 · Oct 29, 2008
Related Publication 20110201641A1 · Aug 18, 2011