Functionalizing a sensing ribbon on a whispering gallery mode microresonator using light force to fabricate a whispering gallery mode sensor
Methods using light force to fabricate WGM sensors including microresonators having target receptors selectively and substantially provided at only ribbon area of the microresonators.
1. A method for fabricating a sensor for determining the presence or concentration of a target entity in a medium, the method comprising:
a) immersing a microresonator in a solution including target receptors;
b) inducing light to resonate within the microresonator, thereby generating an attractive force between a ribbon surface area of the microresonator and the target receptors in the solution, the attractive force attracting the target receptors close enough to the ribbon surface area of the microresonator to permit chemical bonds to hold the target receptors to the ribbon surface area of the microresonator, wherein non-ribbon surface areas of the microresonator are substantially free of target receptors; and
c) passivating the non-ribbon surface areas of the microresonator.
2. The method of claim 1 wherein the microresonator is optically coupled with an optical waveguide, and wherein the act of inducing light to resonate within the microresonator includes sourcing a laser light through the optical waveguide.
3. The method of claim 2 wherein the laser light is in the visible range having a wavelength between 400 nm and 750 nm.
4. The method of claim 2 wherein the laser light has a wavelength of between approximately 1.3 and 1.5 μm.
5. The method of claim 2 wherein the laser light has a wavelength in the near-infrared (NIR) range of between 750 nm and approximately 2.5 μm.
6. The method of claim 1 wherein the microresonator is attached to a core of an optical fiber, and wherein the act of inducing light to resonate within the microresonator includes sourcing a laser light through the optical fiber.
7. The method of claim 1 wherein the microresonator is has a geometry selected from a group of geometries consisting of (A) micro-sphere, (B) micro-ring, (C) micro-cylinder, (D) micro-racetrack, (E) micro-disk and (F) micro-toriod.
8. The method of claim 1 wherein the microresonator is a bottle microresonator.
9. The method of claim 1 wherein the optical waveguide is selected from a group consisting of (A) optical fiber, (B) rib waveguide, (C) channel waveguide and (D) nanowire.
10. The method of claim 1 wherein the solution is a low conductivity solution.
11. The method of claim 10 wherein the low conductivity solution is selected from a group consisting of (A) water and (B) heavy water.
12. The method of claim 10 wherein the low conductivity solution is a phosphate buffered saline solution.
13. The method of claim 1 wherein the chemical bonds are covalent bonds.
14. The method of claim 1 wherein the target receptors include antibodies.
15. The method of claim 1 wherein the target receptors include antibodies provided with a carboxyl group.
16. The method of claim 1 wherein the target receptors have a negative charge.
17. The method of claim 1 wherein the microresonator has a radius of 300 μm or less.
18. The method of claim 1 wherein the microresonator is made of a material selected from a group consisting of (A) glass, (B) silicon, (C) silicon nitride, (D) silicon oxynitride, (E) galiumn nitride, (F) gallium arsenide and (G) indium arsenide.
19. A method for fabricating a sensor for determining the presence or concentration of a target entity in a medium, the method comprising:
a) immersing a microresonator in a solution including target receptors;
b) inducing light to resonate within the microresonator, thereby generating an attractive force between a defined surface area of the microresonator and the target receptors in the solution, the attractive force attracting the target receptors to the defined surface area of the microresonator; and
c) permitting chemical bonds to hold the target receptors to the defined surface area of the microresonator, wherein surface areas of the microresonator other than the defined surface area are substantially free of target receptors.
20. The method of claim 19 further comprising:
d) passivating the surface areas of the microresonator other than the defined surface area