Peptides and nanoparticles for therapeutic and diagnostic applications
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
1. A bioconjugate comprising a metal nanoparticle bound to at least one peptide, wherein said peptide is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. A peptide selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising the bioconjugate of claim 1 or the peptide of claim 2 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
4. A method for treating breast or pancreatic cancer, wherein said cancer overexpresses GAIP interacting protein (GIPC), comprising administering to a patient in need thereof a therapeutically effective amount of a bioconjugate of claim 1 or a peptide of claim 2 , or a pharmaceutically acceptable salt thereof.