Reducing IRF4, DUSP22, or FLJ43663 polypeptide expression
This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.
1. A method for assessing a lymphoma of a mammal, wherein said method comprises:
(a) performing breakapart fluorescence in situ hybridization using a first probe that hybridizes to a 6p25.3 chromosome region and a second probe that hybridizes to a 6p25.3 chromosome region to detect a DUSP22 translocation within said lymphoma, wherein said first and second probes comprise different fluorescent signals, and
(b) classifying said mammal as having anaplastic large-cell lymphoma.
2. The method of claim 1 , wherein said mammal is a human.
3. The method of claim 1 , wherein said method comprises classifying said mammal as having cutaneous anaplastic large-cell lymphoma.