Method for efficient delivery of dual site pacing

1. A method for controlling a multi-site pacing therapy, the method comprising:

selecting a first electrode positioned at a first pacing site along a first heart chamber;

selecting a second electrode positioned at a second pacing site along the first heart chamber;

delivering pacing pulses to the first heart chamber using a bipole comprising the first electrode and the second electrode;

determining whether anodal and cathodal capture can be achieved during pacing using the bipole; and

selecting a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites in response to anodal and cathodal capture being achieved.

2. The method of claim 1 , wherein determining whether anodal and cathodal capture can be achieved comprises establishing a maximum acceptable pacing pulse output for achieving anodal and cathodal capture during pacing using the bipole and determining if anodal and cathodal capture can be achieved during pacing using the bipole at a pacing pulse output that does not exceed the maximum acceptable pacing pulse output.

3. The method of claim 2 , wherein establishing the maximum acceptable pacing pulse output comprises:

determining a cathodal capture threshold for one of the first electrode and the second electrode; and

setting the acceptable maximum pacing pulse output limit in response to the cathodal capture threshold.

4. The method of claim 1 , wherein determining whether anodal and cathodal capture can be achieved comprises determining a conduction time to a distant sensing bipole in response to bipolar pacing using the bipole and at least one of unipolar pacing using the first electrode and unipolar pacing using the second electrode.

5. The method of claim 1 , wherein determining whether anodal and cathodal capture can be achieved comprises determinng one of an evoked response and a cardiac signal morphology.

6. The method of claim 1 , further comprising:

determining an anodal capture threshold for at least one of the first electrode and second electrode;

determining a cathodal capture threshold for at least one of the first electrode and the second electrode; and

setting a pacing pulse energy at a safety pacing margin above a higher one of the anodal capture threshold and the cathodal capture threshold.

7. The method of claim 1 , further comprising:

determining an anodal capture threshold for at least one of the first electrode and the second electrode;

determining a cathodal capture threshold for each of the first electrode and the second electrode;

computing a first estimated battery expenditure for pacing at the first site and the second site using only the bipole; and

computing a second estimated battery expenditure for pacing the first site and the second site using two pacing vectors comprising the first electrode and second electrode selected as cathode electrodes;

wherein determining whether anodal and cathodal capture can be achieved during pacing using the bipole comprises verifying that the first energy expenditure does not exceed the second energy expenditure.

8. The method of claim 1 , further comprising:

performing a capture threshold test; and

selecting a different pacing configuration in response to a change in a capture threshold at one of the first pacing site and the second pacing site.

9. The method of claim 8 , further comprising:

monitoring for loss of capture during pacing using the bipole; and

performing the capture threshold test in response to detecting the loss of capture.

10. The method of claim 1 , wherein delivering the multi-site therapy comprises delivering cardiac resynchronization therapy, wherein the first site and the second site are located along the left ventricle.

11. A medical device for delivering a multi-site pacing therapy, comprising:

a plurality of electrodes to sense cardiac signals and deliver cardiac pacing pulses;

a therapy delivery module to deliver cardiac pacing pulses to a patient's heart via the plurality of electrodes;

a sensing module to sense cardiac signals; and

a controller configured to:

select a first electrode positioned at a first pacing site along a first heart chamber;

select a second electrode positioned at a second pacing site along the first heart chamber;

control the therapy delivery module to deliver pacing pulses to the first heart chamber using a bipole comprising the first electrode and the second electrode;

determine, in response to the sensed cardiac signals, whether anodal and cathodal capture can be achieved during pacing using the bipole; and

selecting a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites in response to anodal and cathodal capture being achieved.

12. The device of claim 11 , wherein the controller is configured to determine whether anodal and cathodal capture can be achieved by establishing a maximum acceptable pacing pulse output for achieving anodal and cathodal capture during pacing using the bipole, and determining whether anodal and cathodal capture can be achieved during pacing using the bipole at a pacing pulse output that does not exceed the maximum acceptable pacing pulse output.

13. The device of claim 12 , wherein establishing the acceptable maximum pacing pulse output comprises:

determining a cathodal capture threshold for one of the first electrode and the second electrode; and

setting the acceptable maximum pacing pulse output using the cathodal capture threshold.

14. The device of claim 11 , wherein determining whether anodal and cathodal capture can be achieved comprises determining an inter-chamber conduction time to a distant sensing bipole in response to bipolar pacing using the bipole and at least one of unipolar pacing using the first electrode and unipolar pacing using the second electrode.

15. The device of claim 11 , wherein determining whether anodal and cathodal capture can be achieved comprises determining one of an evoked response and a cardiac signal morphology.

16. The device of claim 11 , wherein the controller is further configured to:

determine an anodal capture threshold for at least one of the first electrode and second electrode;

determine a cathodal capture threshold for at least one of the first electrode and the second electrode; and

set a pacing pulse energy at a safety pacing margin above a higher one of the anodal capture threshold and the cathodal capture threshold.

17. The device of claim 11 , wherein the controller is further configured to:

determine an anodal capture threshold for at least one of the first electrode and the second electrode;

determine a cathodal capture threshold for each of the first electrode and the second electrode;

compute a first estimated battery expenditure for pacing at the first site and the second site using only the bipole;

compute a second estimated battery expenditure for pacing the first site and the second site using two pacing vectors comprising the first electrode and second electrode selected as cathode electrodes; and

determine whether anodal and cathodal capture can be achieved during pacing using the bipole by verifying that the first energy expenditure does not exceed the second energy expenditure.

18. The device of claim 11 , wherein the controller is further configured to:

perform a capture threshold test; and

select a different pacing configuration in response to a change in a capture threshold at one of the first pacing site and the second pacing site.

19. The device of claim 18 , wherein the controller is further configured to:

monitor for loss of capture during pacing using the bipole; and

perform the capture threshold test in response to detecting the loss of capture.

20. The device of claim 11 , wherein the first site and the second site are located along the left ventricle.

21. A non-transitory computer-readable medium storing a set of instructions which when implemented in a medical device cause the device to perform a method for controlling a multi-site pacing therapy, the method comprising:

selecting a first electrode positioned at a first pacing site along a first heart chamber;

selecting a second electrode positioned at a second pacing site along the first heart chamber;

delivering pacing pulses to the first heart chamber using a bipole comprising the first electrode and the second electrode;

determining whether anodal and cathodal capture can be achieved during pacing using the bipole; and

selecting a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites in responve to anodal and cathodal capture being achieved.