Granted Patent
B2
US 8,691,572 · App. 12/464,037 · Granted Apr 8, 2014
Diagnosing, monitoring and treating inflammation
Assignee:
The Brigham and Women's Hospital, Inc.
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Abstract
The present invention provides methods and compositions for treating chronic inflammatory disease in a subject and associated pharmaceutical compositions, medical devices and systems.
Claims (4)
1. A method for identifying a candidate compound that induces a T regulatory phenotype in CD4+/CD25− cells, comprising the steps of:
contacting a CD4+/CD25− cell comprising a reporter gene under the control of a KLF10 promoter with a candidate compound;
detecting the expression level of the reporter gene,
wherein upregulation of the reporter gene is indicative of a compound that induces the T regulatory phenotype.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Sep 21, 2015
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036644/0139 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 27, 2009
From: FEINBERG, MARK W.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 023009/0370 →
Continuity (4)
Continuation In Part
PCTUS2007023680
· Nov 9, 2007
Provisional Application
60858430
· Nov 10, 2006
Provisional Application
61117228
· Nov 23, 2008