Binding compounds for IL-27
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
1. An isolated antibody, or antigen-binding fragment thereof, that specifically binds to a polypeptide consisting of the mature amino acid sequence of SEQ ID NO: 6.
2. The isolated antibody or antigen-binding fragment of claim 1 , wherein the antibody is a monoclonal antibody.
3. The isolated antibody or antigen-binding fragment of claim 2 , wherein the antibody is a chimeric antibody.
4. The isolated antibody or antigen-binding fragment of claim 2 , wherein the antibody is a humanized antibody.
5. The isolated antibody or antigen-binding fragment of claim 1 , wherein the antibody or fragment is an Fab or F(ab′) 2 antibody fragment.
6. A kit comprising the antibody or fragment of claim 1 , and a compartment, wherein said antibody or fragment is contained within said compartment.
7. The kit of claim 6 wherein the antibody or fragment is detectably labeled.
8. The kit of claim 7 wherein the antibody or fragment is labeled with an enzyme, a fluorescent label, a radioisotope or biotin.