Method for treating a surface with a coating comprising a microencapsulated therapeutic agent and device with treated surface
A method for treating a surface with a therapeutic agent is disclosed. The method comprises precipitating a therapeutic agent from a hydrophilic polymeric base layer with which the therapeutic agent has been complexed, to form a layer comprising microparticles of the therapeutic agent on the hydrophilic polymeric base layer, the hydrophilic polymeric base layer being grafted to the surface. Devices comprising a surface having a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface and a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer are also disclosed.
1. A device comprising:
a surface;
a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface; and
a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer.
2. The device of claim 1 , wherein the device is a medical device.
3. The device of claim 2 , wherein the medical device is an implantable medical device.
4. The device of claim 3 , wherein the implantable medical device comprises a dressing, a pin, a clip, a catheter, a stent, an implant, a tubing, a rod, a prosthesis, a screw, a plate, a stent, an endotracheal tube, a heart valve, a dental implant, or a drug delivery device.
5. The device of claim 2 , wherein the medical device is a device for inducing pleurodesis, preventing restenosis, or for treating tumors.
6. The device of claim 1 , wherein the therapeutic agent comprises silver nitrate.
7. The device of claim 1 , wherein of the microparticles of the therapeutic agent have dimensions in the range of from about 1 μm to about 500 μm.
8. The device of claim 1 , wherein the hydrophilic polymeric base layer has a thickness in the range of about 0.1 μm to about 500 μm.
9. The device of claim 1 , wherein the layer comprising microparticles of the therapeutic agent has a thickness in the range of about 10 μm to about 500 μm.
10. The device of claim 1 , further comprising a hydrophobic polymeric top layer on the layer of the therapeutic agent.
11. The device of claim 10 , wherein the hydrophobic polymeric top layer has a thickness in the range of about 1 μm to about 500 μm.