IP Library › Granted Patent US 8,697,414
Granted Patent B2
US 8,697,414 · App. 13/969,174 · Granted Apr 15, 2014

Degradable clostridial toxins

Inventors: Lance E. Steward (Irvine, CA); Sanjiv Ghanshani (Irvine, CA); Ester Fernandez-Salas (Ann Arbor, MI); Marcella A. Gilmore (Santa Ana, CA); Joseph Francis (Aliso Viejo, CA); Kei Roger Aoki (Coto de Caza, CA)
Assignee: Allergan, Inc.
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Quick Facts
Patent No.
US 8,697,414
App. No.
13/969,174
Granted
Apr 15, 2014
Kind
B2
Abstract

The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

Claims (4)

1. A non-naturally occurring polynucleotide molecule comprising SEQ ID NO:530.

2. A method of producing a non-naturally occurring botulinum neurotoxin comprising the steps of:

a. introducing into an Escherichia coli cell a non-naturally occurring polynucleotide molecule of claim 1 ; and

b. expressing the polynucleotide molecule, wherein expression from the polynucleotide molecule produces the encoded variant botulinum neurotoxin.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 11, 2013
From: STEWARD, LANCE E.; GHANSHANI, SANJIV; FERNANDEZ-SALAS, ESTER; GILMORE, MARCELLA A.; FRANCIS, JOSEPH; AOKI, KEI ROGER
To: ALLERGAN, INC.
Reel/Frame 031575/0598 →
Continuity (3)
Division 13112844 · May 20, 2011
Provisional Application 61346578 · May 20, 2010
Related Publication 20130330807A1 · Dec 12, 2013