Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
1. A compound of a formula
wherein X 1 and X 2 are independently selected from H and F; and R is selected from H, alkyl and substituted alkyl moieties, and a salt, thereof.
2. The compound of claim 1 wherein each of X 1 and X 2 is F.
3. The compound of claim 2 wherein R is H.
4. The compound of claim 1 wherein said compound is an ammonium salt.
5. The compound of claim 4 wherein the counter ion of said ammonium salt is a conjugate base of a protic acid.
6. The compound of claim 2 selected from the (S,S) and (R,R) enantiomers.
7. The compound of claim 6 wherein said compound is the (R,R) enantiomer.