IP Library › Granted Patent US 8,698,031
Granted Patent B2
US 8,698,031 · App. 12/142,545 · Granted Apr 15, 2014

Separation and manipulation of a chiral object

Inventors: Osman Kibar (San Diego, CA); Mirianas Chachisvilis (La Jolla, CA); Eugene Tu (San Diego, CA); Thomas H. Marsilje (San Diego, CA)
Assignee: Dynamic Connections, LLC
C07B57/00B03C7/026B03C1/24
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Quick Facts
Patent No.
US 8,698,031
App. No.
12/142,545
Granted
Apr 15, 2014
Kind
B2
Abstract

Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The method applies to sugars, proteins, and peptides, among other things, and can be used in a wide variety of applications.

Claims (22)

1. A method comprising applying across a chamber a field having a field direction that rotates relative to the chamber to cause spin rotation of chiral objects in a mixture in the chamber, each chiral object's axis of rotation lying within the chiral object itself, the spin rotations of the chiral objects causing a net directional motion of the chiral objects along the axis of rotation of the field, and

effecting a step of an application or process using a result of the net directional motion of the chiral objects.

2. The method of claim 1 in which the chiral objects comprise sugar molecules.

3. The method of claim 2 in which the sugar molecules comprise at least one of monosaccharides, disaccharides, oligosaccharides, or polysaccharides (glycans).

4. The method of claim 1 in which the chiral objects comprise proteins.

5. The method of claim 1 in which the chiral objects comprise peptides.

6. The method of claim 1 in which the application or process comprises a genomics application or process.

7. The method of claim 1 in which the application or process comprises a proteomics application or process.

8. The method of claim 1 also including in which the application or process comprises a glycomics application or process.

9. The method of claim 1 also including in which the application or process comprises a chemical manufacturing application or process.

10. The method of claim 1 also including in which the application or process comprises a food processing application or process.

11. The method of claim 1 also including in which the application or process comprises a forensics application or process.

12. The method of claim 1 also including in which the application or process comprises an academic research application or process.

13. The method of claim 1 also including in which the application or process comprises a solvent purification application or process.

14. The method of claim 1 also including in which the application or process comprises an asymmetric synthesis application or process.

15. The method of claim 1 in which a product outcome of a chemical reaction is purified.

16. The method of claim 1 in which a product outcome of a chemical reaction is quantified.

17. The method of claim 1 in which a product outcome of a chemical reaction is identified.

18. The method of claim 15 , 16 , or 17 in which a product outcome of a chemical reaction comprises a non-racemic product mixture.

19. The method of claim 15 , 16 , or 17 in which a product outcome of a chemical reaction comprises a racemic product mixture.

20. The method of claim 1 in which the chiral objects comprise achiral molecules that have chiral labels attached.

21. The method of claim 20 in which the achiral molecules comprise lipids.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2008
From: KIBAR, OSMAN; CHACHISVILIS, MIRIANAS; TU, EUGENE; MARSILJE, THOMAS H.
To: DYNAMIC CONNECTIONS, LLC
Reel/Frame 021134/0971 →
Continuity (4)
Continuation In Part 12103281 · Apr 15, 2008
Provisional Application 60912309 · Apr 17, 2007
Provisional Application 60987674 · Nov 13, 2007
Related Publication 20080274555A1 · Nov 6, 2008