Vanilloid receptor ligands and use thereof for the production of pharmaceutical preparations

1. A compound of formula A,

in which

X denotes O;

Y denotes a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

n denotes 1;

R 1 and R 4 are H,

R 2 and R 3 , mutually independently, in each case denote H; F; Cl; Br; I, or a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

R 5 denotes H; F; Cl; Br; I; —NH 2 ; —OH; —SH; —NHR 11 ; —NR 12 R 13 ; —OR 14 ; —SR 15 ; or a linear or branched, unsaturated or saturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

T denotes C—R 6 and U denotes C—R 7 and V denotes N and W denotes C—R 8 ;

R 6 and R 7 , mutually independently, in each case denote H; F; Cl; Br; I; or a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

R 8 denotes H; F; Cl; Br; I; —NH 2 ; —OH; —SH; —NHR 11 ; —NR 12 R 13 ; —OR 14 ; —SR 15 ; or a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

denotes an unsaturated or saturated, unsubstituted or at least monosubstituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic residue which residue is in each case one or more of (i) attached to the parent structure via a carbon atom in the ring of the cycloaliphatic residue and may be fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system and (ii) attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or C 2-6 alkenylene group or C 2-6 alkynylene group;

or denotes an unsubstituted or at least monosubstituted 5- to 14-membered aryl or heteroaryl residue, which may be one or more of (i) fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system and (ii) attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or C 2-6 alkenylene group or C 2-6 alkynylene group;

R 11 , R 12 , R 13 , R 14 , R 15 , and R 22 , mutually independently, in each case denote a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

denote an unsaturated or saturated, unsubstituted or at least monosubstituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic residue optionally comprising at least one heteroatom as a ring member, which residue may be one or more of (i) fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system and (ii) attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or 2- to 6-membered heteroalkylene group;

or denote an unsubstituted or at least monosubstituted 5- to 14-membered aryl or heteroaryl residue, which may be one or more of (i) fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system and (ii) attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or 2- to 6-membered heteroalkylene group;

or

R 12 and R 13 , in each case together with the nitrogen atom joining them together as a ring member, form a saturated or unsaturated, unsubstituted or at least monosubstituted 4-, 5-, 6-, 7-, 8- or 9-membered heterocycloaliphatic residue optionally comprising at least one further heteroatom as ring member, which may be fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system;

and

R 25 and R 26 , mutually independently, in each case denote a hydrogen residue; or denote a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

providing that R 25 and R 26 do not in each case denote a hydrogen residue;

wherein unless otherwise stated, the above-stated aliphatic C 1-10 residues may optionally in each case be substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 substituents mutually independently selected from the group consisting of F, Cl, Br, I, —CN, —NO 2 , —OH, —NH 2 , —SH, —O(C 1-5 -alkyl), —S(C 1-5 -alkyl), —NH(C 1-5 -alkyl), —N(C 1-5 -alkyl)(C 1-5 -alkyl), —C(═O)—O—C 1-5 -alkyl, —O—C(═O)—C 1-5 -alkyl, —O-phenyl, phenyl, —OCF 3 and —SCF 3 ;

the above-stated 2- to 6-membered heteroalkylene groups, C 1-6 -alkylene groups, C 2-6 -alkenylene groups and C 2-6 -alkynylene groups may optionally in each case be substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 substituents mutually independently selected from the group consisting of F, Cl, Br, I, —CN, —NO 2 , —OH, —NH 2 , —SH, —O(C 1-5 -alkyl), —S(C 1-5 -alkyl), —NH(C 1-5 -alkyl), —N(C 1-5 -alkyl)(C 1-5 -alkyl), —OCF 3 and —SCF 3 ;

the above-stated (hetero)cycloaliphatic residues may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —C 1-6 -alkylene-OH, ═CH 2 , —O—C 1-5 -alkylene-oxetanyl, —C 1-5 -alkylene —O—C 1-5 -alkylene-oxetanyl, —CH 2 —NH—C 1-5 -alkyl, —CH 2 —N(C 1-5 -alkyl) 2 , —N[C(═O)—C 1-5 -alkyl]-phenyl, —CH 2 —O—C 1-5 -alkyl, oxo (═O), thioxo (═S), F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—C 1-5 -alkyl, —O—C(═O)—C 1-5 -alkyl, —NH 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—C 1-5 -alkyl, —C 1-5 -alkyl, —C(═O)—C 1-5 -alkyl, —C(═O)—OH, —C(═O)—O—C 1-5 -alkyl, —NH—C 1-5 -alkyl, —N(C 1-5 -alkyl) 2 , —NH-phenyl, —N(C 1-5 -alkyl)-phenyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —(CH 2 )-pyridinyl, pyridinyl, —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —N[C(═O)—C 1-5 -alkyl]-phenyl, —NH-phenyl, —N(C 1-5 -alkyl)-phenyl, —(CH 2 )-pyridinyl, pyridinyl, —O-phenyl, —O-benzyl, phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, —OH, —CF 3 , —SF 5 , —CN, —NO 2 , —C 1-5 -alkyl, —O—C 1-5 -alkyl, —O—CF 3 , —S—CF 3 , phenyl and —O-benzyl;

the rings of the above-stated mono- or polycyclic ring systems may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of oxo (═O), thioxo (═S), F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—C 1-5 -alkyl, —NH 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—C 1-5 -alkyl, —C 1-5 -alkyl, —C(═O)—C 1-5 -alkyl, —C(═O)—OH, —C(═O)—O—C 1-5 -alkyl, —NH—C 1-5 -alkyl, —N(C 1-5 -alkyl) 2 , —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues —O-phenyl, —O-benzyl, phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, —OH, —CF 3 , —SF 5 , —CN, —NO 2 , —C 1-5 -alkyl, —O—C 1-5 -alkyl, —O—CF 3 , —S—CF 3 , phenyl and —O-benzyl,

and the above-stated aryl or heteroaryl residues may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—C 1-5 -alkyl, —NH 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—C 1-5 -alkyl, —C 1-5 -alkyl, —C(═O)—OH, —C(═O)—O—C 1-5 -alkyl, —NH—C 1-5 -alkyl, —N(C 1-5 -alkyl) 2 , —NH—S(═O) 2 —C 1-5 -alkyl, —NH—C(═O)—O—C 1-5 -alkyl, —C(═O)—H, —C(═O)—C 1-5 -alkyl, —C(═O)—NH 2 , —C(═O)—NH—C 1-5 -alkyl, —C(═O)—N—(C 1-5 -alkyl) 2 , —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues —O-phenyl, —O-benzyl, phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, —OH, —CF 3 , —SF 5 , —CN, —NO 2 , —C 1-5 -alkyl, —O—C 1-5 -alkyl, —O—CF 3 , —S—CF 3 , phenyl and —O-benzyl,

and

the above-stated heteroalkylene groups in each case comprise 1, 2 or 3 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen (NH) and sulfur,

the above-stated (hetero)cycloaliphatic residues may in each case optionally comprise 1, 2 or 3 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen and sulfur,

the rings of the above-stated mono- or polycyclic ring systems are in each case 5-, 6- or 7-membered and may in each case optionally comprise 1, 2, 3, 4 or 5 heteroatom(s) as ring member(s), which are mutually independently selected from the group consisting of oxygen, nitrogen and sulfur,

the above-stated heteroaryl residues in each case optionally comprise 1, 2, 3, 4 or 5 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen and sulfur as ring member(s);

a steroisomer thereof, a diastereoisomer thereof, an enantiomer thereof, a racemate thereof or a salt thereof.

2. The compound according to claim 1 , wherein

X denotes O;

n denotes 1;

R 1 , R 3 and R 4 in each case denote H;

R 2 denote methyl; F; Cl; Br or I;

and

R 25 denotes an alkyl residue selected from the group consisting of —CH 2 —OH, —CH 2 —CH 2 —OH, methyl, ethyl and n-propyl or denotes a residue selected from the group consisting of benzyl, phenyl, phenethyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;

R 26 denote a hydrogen residue or denote a residue selected from the group consisting of methyl, ethyl and n-propyl;

or

R 25 and R 26 in each case together with the carbon atom joining them together as a ring member, form a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;

in each case optionally in the form of one of the pure stereoisomers thereof, in particular enantiomers or diastereomers, the racemates thereof or in the form of a mixture of stereoisomers, in particular the enantiomers and/or diastereomers, in any desired mixing ratio, or in each case in the form of corresponding salts or in each case in the form of corresponding solvates.

3. The compound of claim 1 having the formula Ia1

in which

X a denotes O;

na denotes 1;

R 2a denotes F; Cl; Br; I;

R 5a denotes F; Cl; Br; I;

or denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl and cyclohexenyl;

R 8a denotes H; F; Cl; Br; I; —OH; —NH 2 ; NHR 11a ; —NR 12a R 13a ; —OR 14a ; —SR 15a ;

or denotes a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, sec-butyl, isobutyl, tert-butyl, n-butyl, 3-methyl-but-1-yl, 4-methyl-pent-1-yl, n-pentyl, n-hexyl, (3,3)-dimethyl-but-1-yl, (3,3)-dimethyl-but-1-ynyl, 4-methyl-pent-1-ynyl, 1-hexynyl, propynyl, ethynyl, butynyl, pentynyl, 2-methyl-propen-1-yl, 3-methyl-but-2-en-1-yl, 1-pentenyl, 1-octenyl, 1-heptenyl, 1-hexenyl and (3,3)-dimethyl-but-1-enyl;

denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group

R 11a , R 12a , R 13a , R 14a , R 15a and R 22a , mutually independently, in each case

denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, which may in each case be attached via a —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl;

or denote a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12a and R 13a in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which may optionally in each case be substituted with 1 or 2 substituents mutually independently selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl;

R 25a and R 26a , mutually independently, in each case denote a hydrogen residue; denote a residue selected from the group consisting of —CH 2 —OH, —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —CH 2 —OH, isopropyl, n-butyl, sec-butyl, isobutyl, methyl, ethyl and n-propyl;

providing that R 25a and R 26a do not in each case denote a hydrogen residue;

or

R 25a and R 26a in each case together with the carbon atom joining them together as a ring member, form a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.

4. The compound of formula Ia

in which X a , na, R 5a , R 8a and R 2a have the meaning as defined in claim 3 .

5. The compound according to claim 4 , wherein

R 2a denotes F; Cl; Br; I;

R 5a denotes F; Cl; Br; I;

or denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl and cyclohexenyl;

R 8a denotes H; F; Cl; Br; I; —OH; —NH 2 ; —NHR 11a ; —NR 12a R 13a ; —OR 14a ; SR 15a ;

or denotes a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, sec-butyl, isobutyl, tert-butyl, n-butyl, 3-methyl-but-1-yl, 4-methyl-pent-1-yl, n-pentyl, n-hexyl, (3,3)-dimethyl-but-1-yl, (3,3)-dimethyl-but-1-ynyl, 4-methyl-pent-1-ynyl, 1-hexynyl, propynyl, ethynyl, butynyl, pentynyl, 2-methyl-propen-1-yl, 3-methyl-but-2-en-1-yl, 1-pentenyl, 1-octenyl, 1-heptenyl, 1-hexenyl and (3,3)-dimethyl-but-1-enyl;

or denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group and may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of tetrazolyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, indolyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, which may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , —NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH—S(═O) 2 —CH3, —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11a , R 12a , R 13a , R 14a , R 15a and R 22a , mutually independently, in each case

denote a radical from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a radical selected from the group consisting of 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, oxetanyl, cyclopentyl and cyclohexyl, which may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denote a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF 3 , F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12a and R 13a in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of

6. The compound of claim 3 having the formula C1

in which

D denotes CH or N;

pa denotes 0,

qa denotes 0, 1 or 2;

Ka, La and Ma, mutually independently, in each case denote H, —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl or sec-butyl;

Wa denotes —NR 34a R 35a , —CN, —C(═O)—R 36a or —C(═O)—OR 37a ;

and R 34a , R 35a , R 36a and R 37a , mutually independently, in each case denote H or denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl and isobutyl.

7. The compound of claim 4 , having the formula C2

in which

D denotes CH or N;

qa denotes 0, 1 or 2;

Ka, La and Ma, mutually independently, in each case denote H, —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl or sec-butyl;

and R 34a and R 35a , mutually independently, in each case denote H or denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl and isobutyl.

8. The compound of claim 1 having the formula Ib1

in which

nb denotes 0, 1 or 2;

R 2b denotes methyl; —O—CH 3 ; F; Cl; Br or I;

R 8b denotes H; F; Cl; Br; I; —OH; —NH 2 ; —NHR 11b ; NR 12b R 13b ; —OR 14b ; —SR 15b ;

denotes a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, sec-butyl, isobutyl, tert-butyl, n-butyl, n-pentyl, n-hexyl, (3,3)-dimethyl-but-1-yl, 3-methyl-but-1-yl, 4-methyl-pent-1-yl, (3,3)-dimethyl-but-1-ynyl, 4-methyl-pent-1-ynyl, 1-hexynyl, propynyl, ethynyl, butynyl, pentynyl, 2-methyl-propen-1-yl, 3-methyl-but-2-en-1-yl, 1-pentenyl, 1-octenyl, 1-heptenyl, 1-hexenyl and (3,3)-dimethyl-but-1-enyl;

denotes a residue from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group and may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of tetrazolyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, indolyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, which may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , —NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH—S(═O) 2 —CH3, —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11b , R 12b , R 13b , R 14b and R 15b , mutually independently, in each case

denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of oxetanyl, 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, which may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denotes a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which may optionally be substituted in each case with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF 3 , F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12b and R 13b in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which may optionally in each case be substituted with 1 or 2 substituents mutually independently selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, cyclohexyl, cyclopentyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl;

R 25b and R 26b , mutually independently, in each case denote a hydrogen residue; denote an alkyl residue selected from the group consisting of —CH 2 —OH, —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —CH 2 —OH, isopropyl, n-butyl, sec-butyl, isobutyl, methyl, ethyl and n-propyl;

providing that R 25b and R 26b do not in each case denote a hydrogen residue;

or

R 25b and R 26b in each case together with the carbon atom joining them together as a ring member, form a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.

9. The compound of claim 1 having formula Id1

in which

X d denotes O;

nd denotes 1;

R 2d denotes F; Cl; Br; I;

R 5d denotes F; Cl; Br; I;

denotes a residue selected from the group consisting of methyl, ethyl, tert-butyl,

or denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl and cyclohexenyl;

R 10d denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group and in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of tetrazolyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, indolyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, wherein the residue may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , —NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , NH—S(≡O) 2 —CH3, —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11d , R 12d , R 13d , R 14d , R 15d and R 22d , mutually independently, in each case

denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, oxetanyl, cyclopentyl and cyclohexyl, wherein the residue may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denotes a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF 3 , F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12d and R 13d in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which in each case may optionally be substituted with 1 or 2 substituents selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl;

R 25d and R 26d , mutually independently, in each case denote a hydrogen residue; or denote an alkyl residue selected from the group consisting of —CH 2 —OH, —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —CH 2 —OH, isopropyl, n-butyl, sec-butyl, isobutyl, methyl, ethyl and n-propyl;

providing that R 25d and R 26d do not in each case denote a hydrogen residue;

or

R 25d and R 26d in each case together with the carbon atom joining them together as a ring member, form a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.

10. The compound of claim 9 having the formula Id

11. The compound of claim 1 having the formula Ie1

in which

ne denotes 1;

R 2e denotes methyl; F; Cl; Br or I;

R 10e

denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group and in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of tetrazolyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, indolyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, wherein the residue may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , —NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH—S(═O) 2 —CH 3 , —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11e , R 12e , R 13e , R 14e and R 15e , mutually independently, in each case

denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of oxetanyl, 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, wherein the residue may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denote a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF3, F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12e and R 13e in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which in each case may optionally be substituted with 1 or 2 substituents selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl;

R 25e and R 26e , mutually independently, in each denote a hydrogen residue;

or denote an alkyl residue selected from the group consisting of —CH 2 —OH, —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —CH 2 —OH, isopropyl, n-butyl, sec-butyl, isobutyl, methyl, ethyl and n-propyl;

providing that R 25e and R 26e do not in each case denote a hydrogen residue;

or

R 25e and R 26e each case together with the carbon atom joining them together as a ring member, form a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.

12. The compound of claim 11 having the formula Ie

13. The compound according to claim 12 , wherein

R 2e denotes F;

R 10e

denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group and in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of tetrazolyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, indolyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, wherein the residue may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , —NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH—S(═O) 2 —CH 3 , —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11e , R 12e , R 13e , R 14e and R 15e , mutually independently, in each case denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of oxetanyl, 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, wherein the residue may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denote a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF3, F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12e and R 13e in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which in each case may optionally be substituted with 1 or 2 substituents selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl.

14. The compound of claim 1 having the formula If1

in which

nf denotes 1;

R 2f denotes methyl; F; Cl; Br or I;

R 10f

denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a —(CH═CH)—, —C≡C— or —C≡C—CH 2 -group and in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, indolyl, tetrazolyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, wherein the residue may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , —NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH—S(═O) 2 —CH 3 , —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11f , R 12f , R 13f , R 14f and R 15f , mutually independently, in each case

denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of oxetanyl, 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, wherein the residue may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denote a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF3, F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12f and R 13f in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which in each case may optionally be substituted with 1 or 2 substituents selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl;

R 25f and R 26f , mutually independently, in each case denote a hydrogen residue;

or denote an alkyl residue selected from the group consisting of —CH 2 —OH, —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —CH 2 —OH, isopropyl, n-butyl, sec-butyl, isobutyl, methyl, ethyl and n-propyl;

providing that R 25f f and R 26f do not in each case denote a hydrogen residue;

or

R 25f and R 26f in each case together with the carbon atom joining them together as a ring member, form a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.

15. The compound according to claim 14 , wherein

R 2f denotes F;

R 10f

denotes a residue selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, azepanyl, diazepanyl, azocanyl and thiomorpholinyl, which is in each case attached to the parent structure via a carbon atom of the rings of the above-stated residues or via a (CH═CH)—, —C≡C— or —C≡C—CH 2 -group and in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, oxo (═O), thioxo (═S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl and n-pentyl;

or denotes a residue selected from the group consisting of (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, indolyl, tetrazolyl, (2,3)-dihydrothieno[3,4-b][1,4]dioxinyl, benzo[b]furanyl, phenyl, naphthyl, oxazolyl, thiazolyl, imidazolyl, pyrimidinyl, thiophenyl, furanyl and pyridinyl, wherein the residue may in each case be attached via a —(CH═CH)—, —C≡C—, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—CH 3 , —O—C 2 H 5 , NH 2 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH—S(═O) 2 —CH 3 , —NH—S(═O 2 )—C 2 H 5 , —NH—S(═O) 2 —CH(CH 3 ) 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—CH 3 , —S—C 2 H 5 , —S—CH(CH 3 ) 2 , —S—C(CH 3 ) 3 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R 11f , R 12f , R 13f , R 14f and R 15f , mutually independently, in each case

denote a residue selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 3-pentyl, n-heptyl, 4-heptyl, n-octyl, n-nonyl, 5-nonyl, (2,6)-dimethyl-hept-4-yl, 3-methyl-butyl, n-hexyl, (3,3)-dimethylbutyl, —CH 2 —CH 2 —O—CH 3 , —CH 2 —CH 2 —O—C 2 H 5 , —CH 2 —CH 2 —O-phenyl, —CH 2 —CH 2 —CH 2 —O—CH 3 , ethenyl, propenyl, 2-butenyl, 3-butenyl, 2-pentenyl and 3-pentenyl;

denote a residue selected from the group consisting of oxetanyl, 2,3-dihydro-1H-indenyl, piperidinyl, pyrrolidinyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, wherein the residue may in each case be attached via a —CH 2 —O—, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —O—CH 2 —, —CH 2 —CH(CH 3 )—O—CH 2 —, —(CH 2 )—, —(CH 2 ) 2 — or —(CH 2 ) 3 -group and/or in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—CH(CH 3 ) 2 and —C(═O)—O—C(CH 3 ) 3 ;

or denotes a residue selected from the group consisting of —(CH 2 )-pyridinyl, —(CH 2 ) 2 -pyridinyl, benzyl, phenethyl, phenyl, naphthyl, thiophenyl, furanyl, pyrrolyl and pyridinyl, which in each case may optionally be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CF 3 , F, Cl, Br, —O—CH 3 , —O—C 2 H 5 , methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

or

R 12f and R 13f in each case together with the nitrogen atom joining them together as a ring member, form a residue selected from the group consisting of 3-aza-bicyclo[3.1.1]heptyl, 6-aza-spiro[2.5]octyl, 3-aza-bicyclo[3.2.1]octyl, 6-aza-bicyclo[3.3.1]heptyl, 8-aza-bicyclo[3.2.1]octyl, 1-oxa-2,8-diaza-spiro[4.5]dec-2-enyl, azocanyl, isoindolyl, indolyl, (1,2,3,6)-tetrahydropyridinyl, (4,5,6,7)-tetrahydroisoxazolo[5,4-c]pyridinyl, pyrrolidinyl, piperidinyl, (1,2,3,6)-tetrahydropyridinyl, piperazinyl, morpholinyl, azepanyl, diazepanyl and thiomorpholinyl, which in each case may optionally be substituted with 1 or 2 substituents selected from the group consisting of —CH 2 —O—CH 2 -oxetanyl, —O—CH 2 -oxetanyl, —CH 2 —OH, —CH 2 —CH 2 —OH, ═CH 2 , —C(═O)—O—CH 3 , —C(═O)—O—C 2 H 5 , —C(═O)—O—C(CH 3 ) 3 , —C(═O)—CH 3 , —C(═O)—C 2 H 5 , —C(═O)—C(CH 3 ) 3 , —CN, —CH 2 —N(CH 3 ) 2 , —CH 2 —N(C 2 H 5 ) 2 , —CH 2 —NH—CH 3 , —CH 2 —NH—C 2 H 5 , —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, —CH 2 —O—CH 3 , —CH 2 —O—CH 2 —CH 3 , —CH 2 —O—CH 3 , —NH 2 , —NH—CH 3 , —NH—C 2 H 5 , —N(CH 3 ) 2 , —N(C 2 H 5 ) 2 , —NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, oxo (═O), thioxo (═S), —OH, F, Cl, Br, —CF 3 , —O—CH 3 , —O—C 2 H 5 , —O—C(CH 3 ) 3 , —O—CH(CH 3 ) 2 , —O—CH 2 —CH 2 —CH 2 —CH 3 , methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, sec-butyl, piperidinyl, pyrrolidinyl, —O-phenyl, —O—C(═O)—CH 3 , —O—C(═O)—C 2 H 5 , —O—C(═O)—C(CH 3 ) 3 , —(CH 2 )-pyridinyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, pyridinyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, —N—[C(═O)—C 2 H 5 ]-phenyl, —N—[C(═O)—CH 3 ]-phenyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl,

—NH-phenyl, —N(CH 3 )-phenyl, —N(C 2 H 5 )-phenyl, —(CH 2 )-pyridinyl, pyridinyl, phenyl, —O-phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —CF 3 , —OH, —O—CH 3 , —O—C 2 H 5 , F, Cl, Br, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl and sec-butyl;

in each case optionally in the form of one of the pure stereoisomers thereof, in particular enantiomers or diastereomers, the racemates thereof or in the form of a mixture of stereoisomers, in particular the enantiomers and/or diastereomers, in any desired mixing ratio, or in each case in the form of corresponding salts or in each case in the form of corresponding solvates.

16. The compound according to claim 1 selected from the group consisting of

[1] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[2] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[4] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-fluoro-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[5] N-((2-chloro-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[6] N-((-bromo2-bromo-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[7] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-iodo-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[8] N-((2-tert-butyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[10] (S)-2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[11] (R)-2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[12] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-morpholino-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[13] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[14] N-((2-(dimethylamino)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[15] N-((2-(diethylamino)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[16] N-((2-(dipropylamino)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[17] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-hydroxy-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[18] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-methoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[19] N-((2-butoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[20] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[21] N-((2-cyclopentyloxy-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[22] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-phenyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[23] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(4-fluoro-phenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[24] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((6-(trifluoromethyl)-2,2′-bipyridin-3-yl)methyl)propanamide

[25] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((6-(trifluoromethyl)-2,3′-bipyridin-3-yl)methyl)propanamide

[26] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(pyrimidin-2-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[27] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(thiazol-2-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[28] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(oxazol-2-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[29] N-((2-(1H-imidazol-2-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[51] N-((6-tert-butyl-2-(piperidin-1-yl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[57] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)propanamide

[59] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-(2-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)ethyl)propanamide

[64] 2-(3-chloro-4-(methylsulfonamido)phenyl)-N-((2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[65] 2-(3-chloro-4-(methylsulfonamido)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[67] 2-(3-bromo-4-(methylsulfonamido)phenyl)-N-((2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[72] (S)-2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-morpholino-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[73] N-((2-(4-benzylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[74] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-piperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide;

[76] N-((2-(cyclohexyloxy)-6-(trifluoromethyl)pyridin-3-yl)methyl-2-(3-fluoro-4-methylsulfonamido)phenyl)propanamide

[79] N-((2-(3,5-dimethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

[80] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

[81] N-((2-(azepan-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

85 N-(2-dimethylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

87 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-imidazol-1-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

88 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-thiophen-2-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

89 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

90 N-(2-cyclohexylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

91 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-hexyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

93 (S)-2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-hexyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

94 (R)-2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-hexyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

95 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-isobutoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

96 (S)-2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-isobutoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

97 (R)-2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-isobutoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

100 N-(2-cyclopropylmethoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

101 N-(2-cyclobutylmethoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

102 2-(3-chloro-4-methylsulfonamido-phenyl)-N-(2-pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

103 2-(3-bromo-4-methylsulfonamido-phenyl)-N-(2-pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

104 N-(4-benzyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

106 N-(2-benzyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

107 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-methoxy-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

109 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-phenyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

110 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-phenylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

111 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-propoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

112 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-fluoro-phenylamino)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

113 N-[2-(4-chloro-phenylamino)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

115 N-(2-benzylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

116 N-(2-butylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

117 N-[2-(4-tert-butyl-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

118 N-[2-(3-chloro-4-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

120 (S)—N-[2-(3-chloro-4-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

121 (R)—N-[2-(3-chloro-4-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

122 N-(2-butylsulfanyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

123 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-methyl-butoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

124 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(2-methyl-cyclopropylmethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

125 N-[2-(3,3-dimethyl-butoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

126 N-(2-cyclohexylsulfanyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

127 2-(4-methylsulfonamido-3-methyl-phenyl)-N-(6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

128 N-(2-azocan-1-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

131 N-[6′-(chloro-difluoro-methyl)-4-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

132 N-[2-azepan-1-yl-6-(chlor-difluor-methyl)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

134 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-methyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

135 N-[2-(3,4-dimethyl-phenylamino)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

136 N-[2-(5-chloro-2-methyl-phenylamino)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

137 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

138 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-fluoro-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

139 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(6′-trifluoromethyl-3,6-dihydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

140 N-[2-butoxy-6-(chlor-difluor-methyl)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

142 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pentyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

144 (S)-2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pentyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

145 (R)-2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pentyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

147 N-[2-(4-chloro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

148 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

149 N-[2-(3-chloro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

150 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(2-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

151 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-methoxy-phenyl)-6-tfifluoromethyl-pyridin-3-ylmethyl]-propionamide

156 N-(2-cyclobutoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

157 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-methyl-cyclohexyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

158 acetic acid-3′-{[2-(3-fluoro-4-methylsulfonamido-phenyl)-propionylamino]-methyl}-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl ester

159 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-methoxy-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

160 N-(4-butoxy-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

161 N-(2-cyclopentylmethoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

162 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-isopropoxy-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

163 N-(2-ethoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

164 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(6″-trifluoromethyl-3,4,5,6,3′4′5′,6′-octahydro-2H,2′H-[1,4′;1′,2″]terpyridin-3″-ylmethyl)-propionamide

165 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-pyrrolidin-1-yl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

166 N-[6-(chloro-difluoro-methyl)-2-cyclopentyloxy-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

167 N-[2-(butyl-methyl-amino)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

168 N-[6-(chloro-difluoro-methyl)-2-cyclohexyloxy-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

169 N-[2-benzyloxy-6-(chlor-difluor-methyl)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

170 N-[2-(4-tert-butyl-cyclohexyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

171 N-[2-(4-ethyl-cyclohexyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

172 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-methyl-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

173 N-[2-(4-chloro-benzylamino)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

175 N-[2-(4-fluoro-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

176 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-pyridin-4-yl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

177 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(pyridin-4-ylmethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

178 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-phenethyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

179 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-6-trifluoromethyl-pyridin-3-ylmethyl}-propionamide

180 N-[6-(chloro-difluoro-methyl)-2-hexyloxy-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

181 N-[6-(chloro-difluoro-methyl)-2-(pyridin-3-ylmethoxy)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

182 N-[6-(chloro-difluoro-methyl)-2-(pyridin-2-ylmethoxy)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

183 N-(2-dibutylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

184 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[6′-(4-fluoro-phenyl)-4-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl]-propionamide

186 N-[6-(chloro-difluoro-methyl)-2-dipropylamino-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

187 N-[6′-(chloro-difluoro-methyl)-3,5-dimethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

188 N-[2-(1,3-dihydro-isoindol-2-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

189 3′-{[2-(3-fluoro-4-methylsulfonamido-phenyl)-propionylamino]-methyl}-4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carbonic acid ethylester

190 N-(4,6′-bis-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

191 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-styryl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

192 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-phenethyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

193 N-{2-[4-(3-chloro-pyridin-2-yl)-piperazin-1-yl]-6-trifluoromethyl-pyridin-3-ylmethyl}-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

194 N-{2-[4-(3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-pyridin-3-ylmethyl}-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

195 N-(4,6′-bis-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(4-methylsulfonamido-3-methyl-phenyl)-propionamide

196 2-(4-methylsulfonamido-3-methyl-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

197 N-(4-ethyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

198 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-phenoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

199 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-methoxymethyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

200 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[4-(4-fluoro-phenyl)-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl]-propionamide

201 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-6-trifluoromethyl-pyridin-3-ylmethyl}-propionamide

202 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(pyridin-2-ylmethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

203 2-(4-methylsulfonamido-3-methyl-phenyl)-N-[2-(4-phenyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

204 N-(2-benzyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(4-methylsulfonamido-3-methyl-phenyl)-propionamide

205 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(methyl-phenyl-amino)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

207 N-[6-(chloro-difluoro-methyl)-2-(4-phenyl-piperazin-1-yl)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

208 N-[6-(chloro-difluoro-methyl)-2-isobutoxy-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

210 N-(4,4-dimethyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

212 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{6-trifluoromethyl-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyridin-3-ylmethyl}-propionamide

213 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{6-trifluoromethyl-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyridin-3-ylmethyl}-propionamide

214 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-pyridin-2-yl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

215 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

219 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-p-tolyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

220 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-m-tolyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

221 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{2-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-trifluoromethyl-pyridin-3-ylmethyl}-propionamide

222 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{6-trifluoromethyl-2-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylmethyl}-propionamide

223 N-(2-benzyloxy-4-hydroxymethyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

225 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pentyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

226 2,2-dimethyl-propionic acid-3′-{[2-(3-fluoro-4-methylsulfonamido-phenyl)-propionylamino]-methyl}-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl ester

227 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-oxo-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

228 N-(4-ethoxy-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

233 N-(6-tert-butyl-2-cyclohexyloxy-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

234 N-(6-tert-butyl-2-cyclopentyloxy-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

235 N-(2-butoxy-6-tert-butyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

236 N-(6-tert-butyl-2-hexyloxy-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

237 N-(2-benzyloxy-6-tert-butyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

240 N-(6-tert-butyl-2-pyrrolidin-1-yl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

241 N-(6′-tert-butyl-4-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

242 N-[2-(4-ethyl-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

243 N-[2-(4-butyl-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

244 N-[2-(4-tert-butyl-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

245 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(indan-2-yloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

250 N-[2-(3,4-dichloro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

251 N-[2-(3-tert-butyl-1-oxa-2,8-diaza-spiro[4.5]dec-2-en-8-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

252 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-phenyl-1-oxa-2,8-diaza-spiro[4.5]dec-2-en-8-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

254 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-fluoro-4-methoxy-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

255 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{2-[4-(4-fluoro-phenyl)-piperidin-1-yl]-4-trifluoromethyl-benzyl}-propionamide

256 N-(2-butoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(4-methylsulfonamido-3-methyl-phenyl)-propionamide

257 N-(2-hexyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(4-methylsulfonamido-3-methyl-phenyl)-propionamide

258 N-[2-(4-chloro-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

259 N-(4-dimethylaminomethyl-4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

260 N-[2-(4-cyclohexyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

261 N-(6-tert-butyl-2-cyclopentyloxy-4-hydroxymethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionami de

262 2-(4-methylsulfonamido-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

263 N-[2-(3,3-dimethyl-butyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

264 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(2-p-tolyl-ethyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

265 N-[2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

266 N-(2-benzo[1,3]dioxol-5-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

267 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-hexyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

268 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-methyl-pentyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

269 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-hydroxy-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

270 N-(2-cyclohexylmethoxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

271 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-methyl-cyclohexylmethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

272 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-methylsulfonamido-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

273 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(2-methyl-propenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

274 N-[2-(3,3-dimethyl-but-1-enyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

275 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(1H-indol-6-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

276 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(1H-indol-5-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

277 N-[2-(4-chloro-3-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

278 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(4-fluoro-3-methyl-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

279 N-[2-(2,2-dimethyl-cyclopropylmethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

282 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(3-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

283 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

285 N-(4-cyano-4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

287 2-(4-ethanesulfonylamino-3-fluoro-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

288 2-(4-(N,N-dimethylsulfamoylamino)-3-fluorphenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

289 2-(4-methylsulfonamido-3-methoxy-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

290 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-phenylamino-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

291 N-(2-cyclohexyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

293 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-thiopropionamide

294 N-(2-cyclohexylsulfanyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

295 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

296 N-(2-azepan-1-yl-6-tert-butyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

297 N-(6-tert-butyl-2-dipropylamino-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

298 N-(2-but-2-enyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

299 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pent-2-enyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

300 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pent-1-enyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

301 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-pent-1-enyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

302 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-hexyloxy-4-methyl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

303 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-{2-[2-(4-fluoro-phenyl)-ethyl]-6-trifluoromethyl-pyridin-3-ylmethyl}-propionamide

304 N-(4-acetyl-4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

307 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[4-(phenyl-propionyl-amino)-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl]-propionamide

308 N-[2-(4-dimethylamino-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

309 2-[3-fluoro-4-(propan-2-sulfonylamino)-phenyl]-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

310 2-[3-fluoro-4-(2,2,2-trifluor-ethansulfonylamino)-phenyl]-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

311 N-[2-(2,6-dimethyl-morpholin-4-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

312 2-(3-fluoro-4-trifluormethylsulfonamido-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

314 N-[2-(1,1-dioxo-1l6-thiomorpholin-4-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

315 N-(6′-difluormethyl-4-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

316 N-(4,6′-dimethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

317 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-phenyl-6′-trifluoromethyl-3,6-dihydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

318 N-(4,4′-dimethyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

326 N-[2-(3,4-dimethoxy-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

327 4-(3-{[2-(3-fluoro-4-methylsulfonamido-phenyl)-propionylamino]-methyl}-6-trifluoromethyl-pyridin-2-yloxymethyl)-piperidine-1-carbonic acid tert-butyl ester

328 N-(6-tert-butyl-2-pentyloxy-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

329 N-[6-tert-butyl-2-(3-methyl-butoxy)-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

330 N-(4-dimethylamino-4-phenyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

331 N-(2-dipropylamino-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(4-methylsulfonamido-3-methyl-phenyl)-propionamide

332 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[4-(4-fluoro-phenyl)-6′-trifluoromethyl-3,6-dihydro-2H-[1,2′]bipyridinyl-3′-ylmethyl]-propionamide

334 N-(2-cyclohex-1-enyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

335 N-[2-(1-ethyl-propoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

336 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(1-propyl-butoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

337 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(1-isobutyl-3-methyl-butoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

338 N-[2-(4,4-dimethyl-cyclohexyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

339 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[6-trifluoromethyl-2-(4-trifluoromethyl-cyclohexyloxy)-pyridin-3-ylmethyl]-propionamide

340 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[6-trifluoromethyl-2-(4-trifluoromethyl-cyclohexyloxy)-pyridin-3-ylmethyl]-propionamide

341 4-(3-{[2-(3-fluoro-4-methylsulfonamido-phenyl)-propionylamino]-methyl}-6-trifluoromethyl-pyridin-2-yloxy)-piperidine-1-carbonic acid tert-butyl ester

342 4-[(3-{[2-(3-fluoro-4-methylsulfonamido-phenyl)-propionylamino]-methyl}-6-trifluoromethyl-pyridin-2-ylamino)-methyl]-piperidine-1-carbonic acid tert-butyl ester

343 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(piperidin-4-ylmethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

344 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(piperidin-4-yloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

345 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(2-p-tolyloxy-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

346 N-[2-(2-cyclohexyl-vinyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

347 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-methyl-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-butyramide

348 N-[2-(3,5-dimethoxy-phenyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

349 N-(2-cyclopentyloxy-4-methyl-6-trifluoromethyl-pyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

351 ethyl 5-((2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(4-methylpiperidin-1-yl)-2-(trifluoromethyl)nicotinat

352 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(nonan-5-yloxy)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

353 N-((6-tert-butyl-2-isobutoxypyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

354 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(phenylethynyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

355 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(3-methoxypropoxy)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

356 N-((2-(4-benzylpiperidin-1-yl)-4-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide

357 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-methylene-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

358 N-[2-(6-aza-spiro[2.5]oct-6-yl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

359 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(3-methyl-but-2-enyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

360 N-[2-(3-cyclohexyl-propyl)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

361 N-[2-(3-ethoxy-propoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

362 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-[2-(2-phenoxy-ethoxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-propionamide

363 N-[2-(3,5-dimethoxy-benzyloxy)-6-trifluoromethyl-pyridin-3-ylmethyl]-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

364 2-(3-fluoro-4-methylsulfonamido-phenyl)-N-(4-hydroxymethyl-6′-trifluoro methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-propionamide

365 N-(6′-tert-butyl-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-ylmethyl)-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

366 N-{6-tert-butyl-2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-pyridin-3-ylmethyl}-2-(3-fluoro-4-methylsulfonamido-phenyl)-propionamide

367 2-(4-methylsulfonamido-3-methyl-phenyl)-N-(2-pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-ylmethyl)-propionamide

[368] N-((2-(1H-indol-4-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[369] N-((6-tert-butyl-2-propoxypyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[370] N-((6-tert-butyl-2-(3-methoxypropoxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[371] N-((6-tert-butyl-2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[372] N-((6-tert-butyl-2-methoxypyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[373] N-((6-tert-butyl-2-ethoxypyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[374] N-((6-tert-butyl-2-isopropoxypyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[375] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(pentyloxy)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide,

[376] 2-(3-fluoro-4-(methylsulfonamido)phenyl)-N-((2-(hexyloxy)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide,

[377] N-((2-(3,5-dimethylcyclohexyloxy)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

[378] N-((6-tert-butyl-2-(2-ethoxyethoxy)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide,

a stereoisomer thereof, an enantiomer thereof, a diastereomer thereof and a racemate thereof.

17. A pharmaceutical preparation containing at least one compound according to claim 1 and optionally one or more physiologically acceptable auxiliary substances.

18. The compound of claim 1 , wherein

R 2 and R 3 are each independently selected from the group consisting of H, F, Cl, Br, I and a aliphatic C 1-10 residue;

R 7 is H;

R 6 is a saturated or unsaturated C 1-10 aliphatic residue.

19. A compound of formula A

in which

X denotes O;

Y denotes a linear or branched, saturated or unsaturated aliphatic C 1-10 residue;

n denotes 1;

R 1 and R 4 , mutually independently, in each case denote H;

R 2 R 3 , mutually independently, in each case denote H; F; Cl; Br; I; or a linear or branched, saturated or unsaturated aliphatic C 1-10 residue;

R 5 denotes H, or a linear or branched, unsaturated aliphatic C 1-10 residue;

T denotes C—R 6 and U denotes C—R 7 and V denotes N and W denotes C—R 8

R 6 and R 7 , mutually independently denotes H; F; Cl; Br; I; a linear or branched, saturated or unsaturated aliphatic C 1-10 residue; or a 6- or 10-membered aryl residue, which may be attached via a linear or branched C 1-6 alkylene group;

R 8 denotes H; F; Cl; Br; I; a saturated or unsaturated chain comprising 1 to 7 carbon atoms as chain members;

an unsaturated or saturated 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic residue optionally comprising at least one heteroatom as a ring member, which residue is in each case attached to the parent structure via a carbon atom in the ring of the cycloaliphatic residue and may be attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or C 2-6 alkenylene group or C 2-6 alkynylene group; and

R 25 and R 26 , mutually independently, in each case denote a hydrogen residue; or a linear or branched, saturated or unsaturated aliphatic C 1-10 residue

a steroisomer thereof, a diastereoisomer thereof, an enantiomer thereof, a racemate thereof or a salt thereof.

20. The compound of claim 1 , wherein

R 5 is an unsubstituted, saturated, branched or unbranched aliphatic C 1-10 residue;

R 6 is H or an unsubstituted, saturated, branched or unbranched aliphatic C 1-10 residue;

R 7 is H;

R 8 is selected from the group consisting of H, F, Cl, Br, I, an unsubstituted, saturated or unsaturated, branched or unbranched aliphatic C 1-10 residue, OR 15 , SR 15 , wherein R 15 is selected from the group consisting of H, a saturated or unsaturated, branched or unbranched aliphatic C 1-10 residue which may be substituted with one or more of OH, O-phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, benzoyl, phenyl, pyridyl, NH 2 , piperidinyl, pyrrolidinyl, azepanyl, indolyl, thiophenyl, thiazolyl, imidazolyl, oxazolyl, pyrimidinyl, piperazinyl, morpholinyl and thiomorpholinyl.

21. A compound of formula A,

in which

X denotes O;

Y denotes a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

n denotes 1;

R 1 and R 4 are H;

R 2 and R 3 , mutually independently, in each case denote H; F; Cl; Br; I; or a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

R 5 is an unsubstituted, saturated, branched or unbranched aliphatic C 1-10 residue;

T denotes C—R 6 ;

U denotes C—R 7 ;

V denotes N;

W denotes C—R 8 ;

R 6 is H or an unsubstituted, saturated, branched or unbranched aliphatic C 1-10 residue;

R 7 is H;

R 8 is selected from the group consisting of H, F, Cl, Br, I, an unsubstituted, saturated or unsaturated, branched or unbranched aliphatic C 1-10 residue, OR 15 , SR 15 , wherein R 15 is selected from the group consisting of H, a saturated or unsaturated, branched or unbranched aliphatic C 1-10 residue which may be substituted with one or more of OH, O-phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, benzoyl, phenyl, pyridyl, NH 2 , piperidinyl, pyrrolidinyl, azepanyl, indolyl, thiophenyl, thiazolyl, imidazolyl, oxazolyl, pyrimidinyl, piperazinyl, morpholinyl and thiomorpholinyl;

R 15 denotes a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

denote an unsaturated or saturated, unsubstituted or at least monosubstituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic residue optionally comprising at least one heteroatom as a ring member, which residue may be one or more of (i) fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system and (ii) attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or 2- to 6-membered heteroalkylene group;

or denote an unsubstituted or at least monosubstituted 5- to 14-membered aryl or heteroaryl residue, which may be one or more of (i) fused with a saturated or unsaturated, unsubstituted or at least monosubstituted mono- or polycyclic ring system and (ii) attached via a linear or branched, unsubstituted or at least monosubstituted C 1-6 alkylene group or 2- to 6-membered heteroalkylene group;

and R 25 and R 26 , mutually independently, in each case denote a hydrogen residue; or denote a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

providing that R 25 and R 26 do not in each case denote a hydrogen residue;

wherein unless otherwise stated, the above-stated aliphatic C 1-10 residues may optionally in each case be substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 substituents mutually independently selected from the group consisting of F, Cl, Br, I, —CN, —NO 2 , —OH, —NH 2 , —SH, —O(C 1-5 -alkyl), —S(C 1-5 -alkyl), —NH(C 1-5 -alkyl), —N(C 1-5 -alkyl)(C 1-5 -alkyl), —C(═O)—O—C 1-5 -alkyl, —O—C(═O)—C 1-5 -alkyl, —O-phenyl, phenyl, —OCF 3 and —SCF 3 ;

the above-stated 2- to 6-membered heteroalkylene groups, C 1-6 -alkylene groups, C 2-6 -alkenylene groups and C 2-6 -alkynylene groups may optionally in each case be substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 substituents mutually independently selected from the group consisting of F, Cl, Br, I, —CN, —NO 2 , —OH, —NH 2 , —SH, —O(C 1-5 -alkyl), —S(C 1-5 -alkyl), —NH(C 1-5 -alkyl), —N(C 1-5 -alkyl)(C 1-5 -alkyl), —OCF 3 and —SCF 3 ;

the above-stated (hetero)cycloaliphatic residues may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of —C 1-6 -alkylene-OH, ═CH 2 , —O—C 1-5 -alkylene-oxetanyl, —C 1-5 -alkylene —O—C 1-5 -alkylene-oxetanyl, —CH 2 —NH—C 1-5 -alkyl, —CH 2 —N(C 1-5 -alkyl) 2 , —N[C(═O)—C 1-5 -alkyl]-phenyl, —CH 2 —O—C 1-5 -alkyl, oxo (═O), thioxo (═S), F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—C(═O)—C 1-5 -alkyl, —NH 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, alkyl, —C 1-5 -alkyl, —C(═O)—C 1-5 -alkyl, —C(═O)—OH, —C(═O)—O—C 1-5 -alkyl, alkyl, —N(C 1-5 -alkyl) 2 , —NH-phenyl, —N(C 1-5 -alkyl)-phenyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —(CH 2 )-pyridinyl, pyridinyl, —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues oxetanyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —N[C(═O)—C 1-5 -alkyl]-phenyl, —NH-phenyl, —N(C 1-5 -alkyl)-phenyl, —(CH 2 )-pyridinyl, pyridinyl, —O-phenyl, —O-benzyl, phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, —OH, —CF 3 , —SF 5 , —CN, —NO 2 , —C 1-5 -alkyl, —O—C 1-5 -alkyl, —O—CF 3 , —S—CF 3 , phenyl and —O-benzyl;

the rings of the above-stated mono- or polycyclic ring systems may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of oxo (═O), thioxo (═S), F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—C 1-5 -alkyl, —NH 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —C 1-5 -alkyl, —C(═O)—C 1-5 -alkyl, —C(═O)—OH, —C(═O)—O—C 1-5 -alkyl, —N(C 1-5 -alkyl) 2 , —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues —O-phenyl, —O-benzyl, phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, —OH, —CF 3 , —SF 5 , —CN, —NO 2 , —C 1-5 -alkyl, —O—C 1-5 -alkyl, —O—CF 3 , —S—CF 3 , phenyl and —O-benzyl,

and the above-stated aryl or heteroaryl residues may optionally in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, I, —CN, —CF 3 , —SF 5 , —OH, —O—C 1-5 -alkyl, —NH 2 , —NO 2 , —O—CF 3 , —S—CF 3 , —SH, —S—C 1-5 -alkyl, —C 1-5 -alkyl, —C(═O)—OH, —C(═O)—O—C 1-5 -alkyl, —NH—C 1-5 -alkyl, —N(C 1-5 -alkyl) 2 , —NH—S(═O) 2 —C 1-5 -alkyl, —NH—C(═O)—O—C 1-5 -alkyl, —C(═O)—H, —C(═O)—C 1-5 -alkyl, —C(═O)—NH 2 , —C(═O)—NH—C 1-5 -alkyl, —C(═O)—N—(C 1-5 -alkyl) 2 , —O-phenyl, —O-benzyl, phenyl and benzyl, wherein in each case the cyclic moiety of the residues —O-phenyl, —O-benzyl, phenyl and benzyl may optionally be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl, Br, —OH, —CF 3 , —SF 5 , —CN, —NO 2 , —C 1-5 -alkyl, —O—C 1-5 -alkyl, —O—CF 3 , —S—CF 3 , phenyl and —O-benzyl,

and

the above-stated heteroalkylene groups in each case comprise 1, 2 or 3 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen (NH) and sulfur,

the above-stated (hetero)cycloaliphatic residues may in each case optionally comprise 1, 2 or 3 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen and sulfur,

the rings of the above-stated mono- or polycyclic ring systems are in each case 5-, 6- or 7-membered and may in each case optionally comprise 1, 2, 3, 4 or 5 heteroatom(s) as ring member(s), which are mutually independently selected from the group consisting of oxygen, nitrogen and sulfur,

the above-stated heteroaryl residues in each case optionally comprise 1, 2, 3, 4 or 5 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen and sulfur as ring member(s);

a steroisomer thereof, a diastereoisomer thereof, an enantiomer thereof, a racemate thereof or a salt thereof.

22. The compound of claim 20 , wherein

R 2 and R 3 , mutually independently, in each case denote H; F; Cl; Br; I; or a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

R 5 is an unsubstituted, saturated, branched or unbranched aliphatic C 1-10 residue;

T denotes C—R 6 and U denotes C—R 7 and V denotes N and W denotes C—R 8 ;

R 6 is H or an unsubstituted, saturated, branched or unbranched aliphatic C 1-10 residue;

R 7 is H;

R 8 is selected from the group consisting of H, F, Cl, Br, I, an unsubstituted, saturated or unsaturated, branched or unbranched aliphatic C 1-10 residue, OR 15 , SR 15 , wherein R 15 is selected from the group consisting of H, a saturated or unsaturated, branched or unbranched aliphatic C 1-10 residue which may be substituted with one or more of OH, O-phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, benzoyl, phenyl, pyridyl, NH 2 , piperidinyl, pyrrolidinyl, azepanyl, indolyl, thiophenyl, thiazolyl, imidazolyl, oxazolyl, pyrimidinyl, piperazinyl, morpholinyl and thiomorpholinyl;

R 15 denotes a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

and R 25 and R 26 , mutually independently, in each case denote a hydrogen residue; or denote a linear or branched, saturated or unsaturated, unsubstituted or at least monosubstituted aliphatic C 1-10 residue;

providing that R 25 and R 26 do not in each case denote a hydrogen residue.