Aromatic amide derivative
A compound represented by the following general formula (I) (R 1 and R 2 represent hydrogen atom, an alkyl group, a halogen atom, etc.; R 3 and R 4 represent hydrogen atom, an alkyl group, an alkoxy group, or an alkenyl group; R 5 represents hydrogen atom, an alkyl group, or nitro group, and R 6 represents hydrogen atom or an alkyl group), which acts on the transcription process of genes.
1. A compound of formula (I) or a salt thereof:
wherein R 1 represents a group selected from the group consisting of a halogen atom, an amino group, or a mono- or dialkyl-substituted amino group;
R 2 represents a hydrogen atom;
R 3 represents a 3-carboxy-1-propyl group wherein the carboxyl group may form an ester;
R 4 represents a hydrogen atom; and
R 5 and R 6 bind together to become a methylene group (—CH 2 —) and thereby form a 5-membered ring.
2. 4-[4-(6-Dimethylamino-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid or an alkyl ester thereof, 4-[4-(6-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid or an alkyl ester thereof, or 4-[4-(6-dimethylamino-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid or an alkyl ester thereof.
3. 6-Dimethylamino-2-(4-propyl-phenyl)-isoindol-1-one, 5-dimethylamino-2-(4-cyclohexyl-phenyl)-isoindol-1-one, or 7-dimethylamino-2-(4-methoxyphenyl)-2,3-dihydro-isoindol-1-one.
4. A composition for inhibiting luciferase activity, which comprises the compound of formula (I) or a salt thereof according to claim 1 .
5. A composition for inhibiting luminescence for a bioluminescence system containing a luciferase and luciferin, which comprises the compound of formula (I) or a salt thereof according to claim 1 .
6. A method for inhibiting luciferase activity, which comprises contacting the compound of formula (I) or a salt thereof according to claim 1 with luciferase.
7. A method for inhibiting luminescence for a bioluminescence system containing a luciferase and luciferin, which comprises combining the compound of formula (I) or a salt thereof according to claim 1 with the bioluminescence system.