Antigen-binding proteins comprising recombinant protein scaffolds
Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
1. A multifunctional antigen-binding protein, comprising at least one multifunctional recombinant protein scaffold comprising SEQ ID NO. 3 or SEQ ID NO. 4 and a 4D5-scFv antibody fragment.
2. The multifunctional antigen-binding protein of claim 1 , wherein the at least one multifunctional recombinant protein scaffold is a humanized sequence of SEQ ID NO. 3.
3. The multifunctional antigen-binding protein of claim 1 , wherein said multifunctional antigen-binding protein comprises SEQ ID NO. 10.
4. A composition comprising the multifunctional antigen-binding protein of claim 1 and a pharmaceutically acceptable carrier.
5. A composition comprising the multifunctional antigen-binding protein of claim 2 and a pharmaceutically acceptable carrier.
6. A composition comprising the multifunctional antigen-binding protein of claim 3 and a pharmaceutically acceptable carrier.