Non-systemic control of parasites
Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.
1. A method for non-systemically controlling a parasitic insect selected from fleas and lice on a human or animal, said method comprising contacting said parasitic insect with an effective amount therefor of a compound that is an agonist or antagonist of the nicotinergic acetylcholine receptor in an insect, said compound having the formula II or III:
in which
n represents 1 or 2;
Subst. represents halogen;
A and Z together with the nitrogen and carbon atom to which they are bonded form a saturated heterocyclic ring having 5 ring members and no further ring heteroatoms in addition to said nitrogen;
E represents an electron-attracting radical; and
X represents the radicals —CH═ or —N═, it being possible for the radical —CH═ to be linked to the radical Z instead of a hydrogen atom;
wherein said contacting of said parasitic insect with said compound is effected by:
a) topically applying said agonist or antagonist to the dermis of said human or animal; or
b) contacting the dermis of said human or animal with an article containing said agonist or antagonist;
and wherein said contacting of said parasitic insect with said compound does not result in said compound being systemically distributed within said human or animal.
2. The method according to claim 1 , wherein the parasitic insects are fleas.
3. The method according to claim 1 , wherein the parasitic insects are lice.
4. The method according to claim 1 , which is carried out on an animal, wherein said animal is a dog or cat infested with fleas.
5. The method according to claim 1 , which is carried out on a human, wherein the human is infected with lice.
6. A method for non-systemically controlling a parasitic insect selected from fleas and lice on a human or animal, said method comprising contacting said parasitic insect with an effective amount therefor of a compound that is an agonist or antagonist of the nicotinergic acetylcholine receptor in an insect, said compound having the formula:
wherein said contacting of said parasitic insect with said compound is effected by:
a) topically applying said agonist or antagonist to the dermis of said human or animal; or
b) contacting the dermis of said human or animal with an article containing said agonist or antagonist;
and wherein said contacting of said parasitic insect with said compound does not result in said compound being systemically distributed within said human or animal.
7. The method according to claim 1 , wherein said contacting of said parasitic insect with said compound of formula II or III does not involve additionally contacting said parasitic insect with another active compound selected from the group consisting of carbamates, organophosphates, amidines, propoxur, amitraz and levamisol.