Granted Patent
B2
US 8,729,099 · App. 11/196,153 · Granted May 20, 2014
Pharmaceutically active piperidine derivatives
Inventors:
Terence D. Butters (Oxford, GB); Raymond A. Dwek (Oxford, GB); George W. J. Fleet (Oxford, GB); Michael Glen Orchard (Abingdon, GB); Frances Mary Platt (Oxford, GB)
Assignee:
Actelion Pharmaceuticals Ltd.
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Abstract
Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
Claims (3)
1. A method for inhibiting glucosylceramide synthase comprising administering to a subject in need thereof an effective amount of the compound (2S,3R,4R,5S)-1-pentyl-2-(hydroxymethyl)-3,4,5-piperidinetriol, in free or pharmaceutically acceptable salt form.
2. The method of claim 1 , wherein the subject in need thereof is suffering from Gaucher disease, Sandhoff's disease, Tay-Sachs disease, Fabry disease or GM1 gangliosidosis.
3. The method of claim 2 , wherein the subject in need thereof is suffering from Fabry disease.
Assignments (7)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBERS 6291657, 8729099, 15526983, 15528407 PREVIOUSLY RECORDED ON REEL 046723 FRAME 0696. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF THE ASSIGNOR'S INTEREST.
Recorded Aug 30, 2018
From: ACTELION PHARMACEUTICALS LTD.
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 046985/0911 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 28, 2018
From: ACTELION PHARMACEUTICALS LTD.
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 046723/0696 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CHANGE FROM "FLEEET" TO "FLEET" AND CHANGE NAME FROM "MASTERS ND SCHOLARS" TO, "MASTERS AND SCHOLARS" PREVIOUSLY RECORDED ON REEL 032457 FRAME 0705. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Mar 28, 2014
From: BUTTERS, TERENCE D.; FLEET, GEORGE; PLATT, FRANCES M.; DWEK, RAYMOND A.
To: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Reel/Frame 032552/0332 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 17, 2014
From: ORCHARD, MICHAEL G.
To: OXFORD GLYCOSCIENCES (UK) LTD
Reel/Frame 032457/0773 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 17, 2014
From: BUTTERS, TERENCE D.; FLEEET, GEORGE; DWEK, RAYMOND A.; PLATT, FRANCES M.
To: THE CHANCELLOR, MASTERS ND SCHOLARS OF THE UNIVERSITY OF OXFORD
Reel/Frame 032457/0705 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 1, 2006
From: UCB S.A.
To: ACTELION PHARMACEUTICALS LTD
Reel/Frame 018040/0690 →
BUSINESS SALE AGREEMENT
Recorded Jul 31, 2006
From: OXFORD GLYCOSCIENCES (UK) LIMITED
To: UCB S.A.
Reel/Frame 018023/0261 →
Continuity (3)
Continuation In Part
PCTGB0200106
· Jan 11, 2002