IP Library › Granted Patent US 8,735,071
Granted Patent B2
US 8,735,071 · App. 13/142,134 · Granted May 27, 2014

Compositions for promoting epigenetic DNA demethylation and methods of use therefore

Inventors: Hongjun Song (Clarksville, MD); Dengke K. Ma (Cambridge, MA); Guo-li Ming (Clarksville, MD)
Assignee: The Johns Hopkins University
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Quick Facts
Patent No.
US 8,735,071
App. No.
13/142,134
Granted
May 27, 2014
Kind
B2
Abstract

The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the treatment of mood disorders.

Claims (3)

1. A method for identifying an agent that modulates DNA demethylation by a Gadd45b polypeptide, the method comprising

(a) contacting a neuronal cell expressing a Gadd45b polypeptide with an agent; and

(b) comparing the DNA demethylation activity of the Gadd45b polypeptide in the presence of the agent with the activity in the absence of the agent; wherein a measurable difference in the activity indicates that the agent modulates activity of the polypeptide.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2011
From: SONG, HONGJUN; MA, DENGKE K.; MING, GUO-LI
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 027421/0880 →
Continuity (2)
Provisional Application 61140702 · Dec 24, 2008
Related Publication 20120088812A1 · Apr 12, 2012