Conjugates that contain the homeodomain of antennapedia
The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof; and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.
1. A synthetic conjugate comprising:
(a) a first region comprising the homeodomain of antennapedia;
(b) a second region at the C-terminus of the first region and not naturally associated with the first region, wherein the second region comprises a DNA binding domain; and
(c) a third region comprising a nucleic acid,
wherein at least the first region is non-denatured.
2. The conjugate according to claim 1 , wherein the first and second regions are associated via a disulfide bond.
3. A pharmaceutical composition comprising the conjugate of claim 1 , in combination with a pharmaceutically-acceptable carrier.
4. The pharmaceutical composition according to claim 3 , in the form of a vaccine.