Highly porous, recognitive polymer systems
View Patent ↗The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.
1. A composition comprising:
one or more active agents disposed in a recognitive polymeric matrix comprising
a methacrylic acid polymerized to form a polymeric hydrogel matrix;
a porosigen distributed in the polymeric hydrogel matrix wherein the porosigen comprises sodium chloride in a final weight percent of between 20 and 90 percent of the composition;
a recognitive molecule disposed in the polymeric hydrogel matrix and associated with the one or more active agents to form a porous recognitive polymeric hydrogel,
wherein the recognitive molecule recognizes a recognized agent and the porous recognitive polymeric hydrogel dissociates in the presence of the recognized agent to release the one or more active agents, wherein the recognitive agent comprises D-glucose and the one or more active agents comprising insulin.
2. The composition of claim 1 , wherein the porous recognitive polymeric hydrogel is swellable and swells, cracks, dissolves, dissociates or melts under conditions of low water or humidity.
3. The composition of claim 1 , wherein the porosigen has a mole percent of between 30 and 90 mole percent of the composition during the polymerization of the polymer.
4. The composition of claim 1 , wherein a loss of structural integrity of the porous recognitive polymeric hydrogel is due to:
osmosis upon the presence and binding of the molecule leading to rupture due to swelling;
change of the solubility of the polymeric network leading to polymer dissolution;
local temperature changes leading to expansion melting or both of the polymeric network or combinations thereof.
5. The composition of claim 1 , wherein the recognitive polymeric matrix is formed into one or more layers.
6. The composition of claim 1 , wherein the recognitive polymeric matrix is formed into one or more layers, each of which recognizes a different recognized agent and each of which provides a barrier to the release of one or more different active or inert agents or both.
7. The composition of claim 1 , wherein the recognitive polymeric matrix is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders or combinations thereof.