Pharmaceutical composition including an HIF-2 alpha inhibitor as an active ingredient for preventing or treating arthritis
View Patent ↗The present invention relates to a pharmaceutical composition for preventing or treating arthritis, including, as an active ingredient, a material which inhibits the expression of the hypoxia-inducible factor-2α (HIF-2α) gene or the activity of the HIF-2α protein. According to the present invention, the HIF-2α of the present invention increases the expression thereof in chondrocytes or tissue in which osteoarthritis is induced, and triggers the expression of various cartilage degeneration factors and the activation of mitogen-activated protein (MAP) kinase. In addition, when HIF-2α is inhibited, the expression level of cartilage degeneration factors and the phosphorylation of MAP kinase are significantly reduced by the inhibited degree of HIF-2α. Thus, the composition of the present invention may be applied to the prevention or treatment of arthritis, and may be used for the development of therapeutics for arthritis.
1. A method for treating arthritis, comprising administering to a subject in need thereof a substance inhibiting the expression of the hypoxia-inducible factor-2α (HIF-2α) gene, wherein the substance is a siRNA, a shRNA, a miRNA or an antisense oligonucleotide.
2. The method according to claim 1 , wherein the arthritis is osteoarthritis, degenerative joint disease, osteochondritis dissecans, ligament injuries, meniscus injuries, malalignment of joint, osteonecrosis, rheumatoid arthritis, juvenile idiopathic arthritis, trauma, inflammatory arthritis or septic arthritis caused by infection.
3. A method for treating arthritis, comprising administering to a subject in need thereof a substance inhibiting the expression of the hypoxia-inducible factor-2α (HIF-2α) gene, wherein the substance is a ribozyme or a DNAzyme.