Compounds and methods for treating autoimmune diseases

1. A compound of Formula I or a prodrug or metabolite thereof;

wherein,

each X 1 and X 3 is independently —O— or —S—;

each X 4 , X 5 and X 6 is independently —CH or —N—;

each X 2 , Y 1 and Y 2 is independently —NR 10 , —S— or —O—;

Cy 1 is an optionally substituted aryl group;

Cy 2 is an optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl or optionally substituted aryl containing one, two or three rings;

R 1 is hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl;

each R 2 , R 3 , R 4 and R 5 is independently selected from absent, hydrogen, halogen, —OR 10 , —SR 10 , —NR 10 R 11 , —C(O)R 10 , —C(O)OR 10 , —C(O)NR 10 R 11 , —N(R 10 )C(O)R 11 , —CF 3 , —CN, —NO 2 , —N 3 , acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl;

G 1 is —N(R 10 )C(O)—, —N(R 10 )C(S)—, —N(R 10 )S(O) 2 —, —N(R 10 )S(O) 2 —[C(R 10 )(R 11 )] W —, —N(R— 10 )C(O)—[C(R 10 )(R 11 )] W —, —N(R 10 )C(S)—[C(R 10 )(R 11 )] W —, —N(R 10 )C(O)N(R 11 )—, —N(R— 10 )C(S)N(R 11 )—, —C(O)O— or —C(O)O—[C(R 10 )(R 11 )] W —;

each n and m is independently selected from 0, 1, 2 or 3;

each v and w is independently selected from 0, 1, 2, 3, 4, 5 or 6;

each R 10 , R 11 , R 12 , R 13 and R 14 is independently absent, hydrogen, halogen, OH, —SH, —NH 2 , —CF 3 , —CN, —NO 2 , —N 3 , —C(O)OH, —C(O)NH 2 , acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two of R 10 , R 11 , R 12 , R 13 and R 14 together with the atoms to which they are attached and any intervening atoms may form an additional optionally substituted, 3, 4, 5, 6 or 7 membered ring.

2. A compound of claim 1 , wherein Cy 1 is selected from;

wherein each R 100 , R 101 , R 102 and R 103 is independently absent, hydrogen, halogen, —OR 10 , —SR 11 , —NR 10 R 11 , —C(O)R 10 , —C(O)OR 10 , —C(O)NR 10 R 11 , —N(R 10 )C(O)R 11 , —CF 3 , —CN, —NO 2 , —N 3 , acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, aliphatic, substituted aliphatic, aryl or substituted aryl.

3. A compound of claim 1 , wherein Cy 2 is selected from:

4. A compound of claim 1 , wherein X 1 is —O— or X 2 is —O— or X 3 is —O— or X 5 is —CH or X 6 is —CH or Y 1 is —NH or Y 2 is —NH or G 1 is —N(H)S(O) 2 —.

5. A compound of claim 1 , wherein n is 1, and R 5 is —CH 3 .

6. A compound of claim 1 , wherein m is 0.

7. A compound of claim 1 , wherein R 1 is hydroxyl substituted alkyl.

8. A compound of claim 1 , wherein R 2 and R 3 are hydrogen and v is 1.

9. A compound of claim 1 , wherein Cy 1 is naphthyl.

10. A compound of claim 1 , wherein Cy 2 is an optionally substituted aryl.

11. A compound selected from Table A, or a pharmaceutically acceptable prodrug or metabolite thereof:

TABLE A

No.

Compound

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

12. A compound selected from Table B, or a pharmaceutically acceptable prodrug or metabolite thereof:

TABLE B

No.

Compound

 1A

 2A

 3A

 4A

 5A

 6A

 7A

 8A

 9A

10A

11A

12A

13A

14A

15A

16A

17A

18A

19A

20A

21A

22A

23A

24A

25A

26A

27A

28A

29A

30A

31A

31B

32A

33A

34A

35A

36A

37A

37B

38A

39A

40A

41A

42A

43A

44A

45A

46A

47A

48A

13. A method for the treatment of an autoimmune disease comprising the step of administering a compound of claim 1 , to a patient in need thereof.

14. The method of claim 13 , wherein said autoimmune disease is selected from multiple sclerosis, Crohn's disease, lupus erythematosus, rheumatoid arthritis, osteoarthritis, psoriasis, ulcerative colitis, type-1 diabetes, pancreatitis, asthma, idiopathic thrombocytopenia purpura, uveitis, Guillain-Barre syndrome or myasthenia gravis.

15. The method of claim 13 , wherein said autoimmune disease is type-1 diabetes.

16. The method of claim 13 , wherein said autoimmune disease is rheumatoid arthritis.

17. The method of claim 13 , wherein said autoimmune disease is lupus.

18. A method of suppressing cytokine-induced beta-cell apoptosis comprising the step of administering a compound according to claim 1 .

19. A method of preparing pancreatic islet cells for preservation or transplantation comprising the step of bringing a compound of claim 1 , into contact with said pancreatic islet cells.

20. The method according to claim 19 , wherein said pancreatic islet cells are Langerhans cells.

21. The method of improving glycemic control in a patient comprising the step of administering a compound of claim 1 , to a patient in need thereof.

22. A method of treating a BCL-2 mediated disease or disorder by administering a compound according to claim 1 , to a subject in need thereof.

23. The method according to claim 22 , wherein said disease or disorder is a cell proliferative disorder.

24. The method according to claim 23 , wherein said cell proliferative disorder is selected from the cell proliferative disorder is selected from breast cancer, prostate cancer, lymphoma, skin cancer, pancreatic cancer, colon cancer, melanoma, malignant melanoma, ovarian cancer, brain cancer, primary brain carcinoma, head-neck cancer, glioma, glioblastoma, liver cancer, bladder cancer, non-small cell lung cancer, head or neck carcinoma, breast carcinoma, ovarian carcinoma, lung carcinoma, small-cell lung carcinoma, Wilms' tumor, cervical carcinoma, testicular carcinoma, bladder carcinoma, pancreatic carcinoma, stomach carcinoma, colon carcinoma, prostatic carcinoma, genitourinary carcinoma, thyroid carcinoma, esophageal carcinoma, myeloma, multiple myeloma, adrenal carcinoma, renal cell carcinoma, endometrial carcinoma, adrenal cortex carcinoma, malignant pancreatic insulinoma, malignant carcinoid carcinoma, choriocarcinoma, mycosis fungoides, malignant hypercalcemia, cervical hyperplasia, leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, chronic granulocytic leukemia, acute granulocytic leukemia, hairy cell leukemia, neuroblastoma, rhabdomyosarcoma, Kaposi's sarcoma, polycythemia vera, essential thrombocytosis, Hodgkin's disease, non-Hodgkin's lymphoma, soft-tissue sarcoma, osteogenic sarcoma, primary macroglobulinemia, and retinoblastoma.

25. A method of treating a deubiquitinase mediated disease or disorder comprising administering to a subject in need thereof a compound according to claim 1 .

26. A composition comprising a compound according to claim 1 and an inhibitor of a BCL-2 protein.

27. The composition according to claim 26 , wherein said inhibitor of a BCL-2 protein is selected from ABT-263, ABT-737, gossypol, chelerythrine chloride, apogossypolone, antimycin A, TW-37, HA14-1, obatoclax (GX15-070), ApoG2, NMB and TM12-06.

28. The composition according to claim 27 , wherein said inhibitor of BCL-2 protein is ABT-737.

29. A method of treating BCL-2 mediated disease or disorder by administering a composition according to claim 27 to a subject in need thereof.

30. The method according to claim 29 , wherein said disease or disorder is a cell proliferative disorder.

31. The method according to claim 30 , wherein said cell proliferative disorder is selected from the cell proliferative disorder is selected from breast cancer, prostate cancer, lymphoma, skin cancer, pancreatic cancer, colon cancer, melanoma, malignant melanoma, ovarian cancer, brain cancer, primary brain carcinoma, head-neck cancer, glioma, glioblastoma, liver cancer, bladder cancer, non-small cell lung cancer, head or neck carcinoma, breast carcinoma, ovarian carcinoma, lung carcinoma, small-cell lung carcinoma, Wilms' tumor, cervical carcinoma, testicular carcinoma, bladder carcinoma, pancreatic carcinoma, stomach carcinoma, colon carcinoma, prostatic carcinoma, genitourinary carcinoma, thyroid carcinoma, esophageal carcinoma, myeloma, multiple myeloma, adrenal carcinoma, renal cell carcinoma, endometrial carcinoma, adrenal cortex carcinoma, malignant pancreatic insulinoma, malignant carcinoid carcinoma, choriocarcinoma, mycosis fungoides, malignant hypercalcemia, cervical hyperplasia, leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, chronic granulocytic leukemia, acute granulocytic leukemia, hairy cell leukemia, neuroblastoma, rhabdomyosarcoma, Kaposi's sarcoma, polycythemia vera, essential thrombocytosis, Hodgkin's disease, non-Hodgkin's lymphoma, soft-tissue sarcoma, osteogenic sarcoma, primary macroglobulinemia, and retinoblastoma.

32. A method for treating a disease or disorder mediated by the abnormal or aberrant expression of one or more gene or gene product selected from

TABLE 1

Accession

No.

Description

1370202_at

HRAS like suppressor 3, Hrasls3

1369268_at

activating transcription factor 3, Atf3

1372013_at

interferon induced transmembrane protein 1 (predicted),

Ifitm1_predicted

1377156_at

similar to Transcription factor 7-like 2 (HMG box

transcription factor 4) (T-cell-specific transcription factor

4) (TCF-4) (hTCF-4), LOC683733

1384391_at

retinol dehydrogenase 10 (all-trans), Rdh10

1373923_at

Retinol dehydrogenase 10 (all-trans), Rdh10

1368868_at

A kinase (PRKA) anchor protein (gravin) 12, Akap12

1393351_at

Retinol dehydrogenase 10 (all-trans), Rdh10

1367918_at

fasciculation and elongation protein zeta 1 (zygin I), Fez1

1368869_at

A kinase (PRKA) anchor protein (gravin) 12, Akap12

1388102_at

leukotriene B4 12-hydroxydehydrogenase, Ltb4dh

1392547_at

hypothetical LOC302884, MGC105649

1396327_at

cytochrome P450, family 2, subfamily j, polypeptide 10

(predicted), Cyp2j10_predicted

1368751_at

potassium voltage-gated channel, delayed-rectifier,

subfamily S, member 3, Kcns3

1373309_at

transmembrane protein 86A (predicted),

Tmem86a_predicted

1368375_a_at

interleukin 15, I115

1370427_at

platelet derived growth factor, alpha, Pdgfa

1388502_at

inositol polyphosphate-5-phosphatase B, Inpp5b

1372111_at

met proto-oncogene /// caveolin, caveolae protein 1 ///

wingless-related MMTV integration site 2 /// ankyrin

repeat, SAM and basic leucine zipper domain containing

1 /// cortactin binding protein 2 /// suppression of

tumorigenicity 7 /// caveolin 2, Asz1 /// Cav1 /// Cav2 ///

Cttnbp2 /// Met /// ST7 /// Wnt2

1374469_at

Transcribed locus, strongly similar to XP_578186.2

PREDICTED: similar to oxidation resistance 1 [ Rattus

norvegicus ], —

1378679_at

ubiquitin specific peptidase 25, Usp25

1379375_at

Platelet derived growth factor, alpha, Pdgfa

1372302_at

family with sequence similarity 82, member C, Fam82c

1372182_at

phosphofructokinase, platelet, Pfkp

1386979_at

developmentally regulated protein TPO1, Tpo1

1390847_at

transmembrane protein 86A (predicted),

Tmem86a_predicted

1390226_at

similar to hypothetical protein LOC340061 (predicted),

RGD1562552_predicted

1374519_at

dedicator of cytokinesis 7, Dock7

1371033_at

transporter 1, ATP-binding cassette, sub-family B

(MDR/TAP) /// transporter 2, ATP-binding cassette, sub-

family B (MDR/TAP) /// proteosome (prosome, macropain)

subunit, beta type 9 /// similar to butyrophilin-like 8

(predicted) /// RT1 class II, locus Da /// RT1 class II, locus

Db1 /// major histocompatibility complex, class II, DM

beta /// major histocompatibility complex, class II, DM

alpha /// RT1 class II, locus Ba /// RT1 class II, locus Bb ///

RT1 class II, locus DOb /// butyrophilin-like 4 /// butyro-

philin-like 5 /// butyrophilin-like 3 /// Tesb pseudogene,

Btnl3 /// Btnl4 /// Btnl5 /// Hla-dma /// Hla-dmb ///

Psmb9 /// RGD1562488_predicted /// RT1-Ba /// RT1-

Bb /// RT1-Da /// RT1-Db1 /// RT1-DOb /// Tap1 ///

Tap2 /// Tesb

1385502_at

Tripartite motif protein 21 (predicted), Trim21_predicted

1371491_at

Notch gene homolog 1 ( Drosophila ), Notch1

1373911_at

periostin, osteoblast specific factor (predicted),

Postn_predicted

1393806_at

MANSC domain containing 1, Mansc1

1373912_at

Ectonucleotide pyrophosphatase/phosphodiesterase 4

(predicted), Enpp4_predicted

1388936_at

cadherin 11, Cdh11

1374404_at

Jun oncogene, Jun

1382074_at

ring finger protein 19B, Rnf19b

1370974_at

vacuolar protein sorting 54 (yeast), Vps54

1368144_at

regulator of G-protein signaling 2, Rgs2

1369788_s_at

Jun oncogene, Jun

1389528_s_at

Jun oncogene, Jun

1369519_at

endothelin 1, Edn1

1395124_at

tryptophanyl-tRNA synthetase, Wars

1376977_at

Prostaglandin E receptor 3 (subtype EP3), Ptger3

1373961_at

similar to 4930453N24Rik protein, MGC95208

1387398_at

protein kinase inhibitor, alpha, Pkia

1389365_at

similar to CG3740-PA, LOC690000

1368856_at

Janus kinase 2, Jak2

1374499_at

CDNA clone MGC: 187619 IMAGE: 8367117, —

1377893_at

similar to CG3740-PA, LOC690000

1387074_at

regulator of G-protein signaling 2, Rgs2

1372602_at

starch binding domain 1, Stbd1

1395135_at

Williams Beuren syndrome chromosome region 27,

Wbscr27

1398840_at

vesicle-associated membrane protein 5, Vamp5

1387800_at

Fas death domain-associated protein, Daxx

1373761_at

similar to Protein FAM60A (Tera protein), LOC686611

1386998_at

aldolase C, Aldoc

1384457_at

similar to Fbxw17 protein (predicted),

RGD1566133_predicted

1371071_at

guanine nucleotide binding protein, beta 4, Gnb4

1369319_at

ADP-ribosylation factor-like 6 interacting protein 5,

Arl6ip5

1385210_at

dedicator of cytokinesis 5 (predicted), Dock5_predicted

1388469_at

Insulin-like growth factor I mRNA, 3′ end of mRNA, —

1385961_at

Kruppel-like factor 5, Klf5

1394077_at

Rho family GTPase 3, Rnd3

1376026_at

downstream neighbor of SON, Donson

1368111_at

ankyrin repeat and BTB (POZ) domain containing 2, Abtb2

1375870_a_at

RNA binding motif, single stranded interacting protein 1,

Rbms1

1375739_at

EH-domain containing 4, Ehd4

1383915_at

hypothetical protein LOC686120, LOC686120

1390507_at

interferon stimulated exonuclease 20, Isg20

1373143_at

similar to hypothetical protein FLJ10652, RGD1309621

1379558_at

Similar to zinc finger protein 748 isoform 2, LOC680222

1380110_at

Janus kinase 2, Jak2

1389263_at

retinoic acid induced 14, Rai14

1373412_at

5′-nucleotidase, cytosolic III (predicted), Nt5c3_predicted

1387851_at

phosphotriesterase related, Pter

1387035_a_at

Rho GTPase activating protein 17, Arhgap17

1377663_at

Rho family GTPase 3, Rnd3

1368321_at

early growth response 1, Egr1

1380513_at

RNA polymerase II associated protein 2, Rpap2

1390237_at

translocase of inner mitochondrial membrane 8 homolog a1

(yeast), Timm8a1

1368571_at

CAP-GLY domain containing linker protein 2, Clip2

1372056_at

CKLF-like MARVEL transmembrane domain containing

6, Cmtm6

1368982_at

protein kinase inhibitor, alpha, Pkia

1388574_at

tryptophanyl-tRNA synthetase, Wars

1373775_at

NEDD8 ultimate buster-1, Nub1

1383013_at

Kruppel-like factor 13, Klf13

1389732_at

Similar to CG4025-PA, LOC679937

1387294_at

SH3-domain binding protein 5 (BTK-associated), Sh3bp5

1385294_at

ets variant gene 6 (TEL oncogene), Etv6

1388027_a_at

reticulon 4, Rtn4

1370428_x_at

RT1 class Ib, locus Aw2 /// RT1 class Ia, locus A1 /// RT1

class Ia, locus A2 /// RT1 class Ib, locus Cl /// RT1 class II,

locus DOa /// RT1 class II, locus Ha /// TAP binding

protein /// discoidin domain receptor family, member 1 ///

leucocyte specific transcript 1 /// Fas death domain-

associated protein /// UDP-Gal:betaGlcNAc beta 1,3-

galactosyltransferase, polypeptide 4 /// synaptic Ras

GTPase activating protein 1 homolog (rat) /// general

transcription factor II H, polypeptide 4 /// procollagen, type

XI, alpha 2 /// RT1 class I, locus Ke4 /// RAB2, member

RAS oncogene family-like /// PHD finger protein 1 /// zinc

finger and BTB domain containing 9 /// POU domain, class

5, transcription factor 1 /// valyl-tRNA synthetase 2-like ///

RT1 class I, CE12 /// RT1 class I, CE1 /// RT1 class I,

CE5 /// RT1 class I, A3 /// WD repeat domain 46 /// MHC

class II region expressed gene KE2 /// zinc finger protein

297 /// lymphotoxin B /// ATPase, H+ transporting, V1 sub-

unit G isoform 2 /// RT1 class I, CE7 /// transcription factor

19 /// HCR (a-helix coiled-coil rod homolog) /// psoriasis

susceptibility 1 candidate 2 (human) /// corneodesmosin ///

RT1 class I, CE14 /// RT1 class I, CE2 /// RT1 class I,

CE4 /// RT1 class I, CE15 /// RT1 class I, CE13 /// RT1

class I, CE11 /// RT1 class I, CE10 /// RT1 class I, CE3 ///

RT1 class I, CE16 /// similar to corneodesmosin,

Atp6v1g2 /// B3galt4 /// Cdsn /// Col11a2 /// Daxx ///

Ddr1 /// Gtf2h4 /// Hcr /// Ke2 /// LOC682408 /// Lst1 ///

Ltb /// Phf1 /// Pou5f1 /// Psors1c2 /// Rab2l /// RT1-A1 ///

RT1-A2 /// RT1-A3 /// RT1-Aw2 /// RT1-CE1 /// RT1-

CE10 /// RT1-CE11 /// RT1-CE12 /// RT1-CE13 /// RT1-

CE14 /// RT1-CE15 /// RT1-CE16 /// RT1-CE2 /// RT1-

CE3 /// RT1-CE4 /// RT1-CE5 /// RT1-CE7 /// RT1-C1 ///

RT1-DOa /// RT1-Ha /// RT1-Ke4 /// Syngap1 /// Tapbp ///

Tcf19 /// Vars2l /// Wdr46 /// Zbtb9 /// Zfp297

1393217_at

ATP-binding cassette, sub-family G (WHITE), member 3-

like 1, Abcg3l1

1371049_at

dihydropyrimidinase-like 4, Dpysl4

1377387_a_at

Transcribed locus, strongly similar to NP_079738.2 endo-

thelin converting enzyme 2 isoform c [ Mus musculus ], —

1385658_at

zinc finger protein 313, Zfp313

1395297_at

similar to hypothetical protein FLJ10652, RGD1309621

1374387_at

ADP-ribosylation factor-like 6 interacting protein 5,

Arl6ip5

1369633_at

chemokine (C—X—C motif) ligand 12, Cxcl12

1389014_at

pre-B-cell colony enhancing factor 1, Pbef1

1387257_at

secretin, Sct

1387646_a_at

Max protein, Max

1370463_x_at

RT1 class I, CE16, RT1-CE16

1381567_at

zinc finger with UFM1-specific peptidase domain, Zufsp

1368181_at

methylenetetrahydrofolate dehydrogenase (NADP+

dependent), methenyltetrahydrofolate cyclohydrolase,

formyltetrahydrofolate synthase, Mthfd1

1374678_at

sema domain, immunoglobulin domain (Ig),

transmembrane domain (TM) and short cytoplasmic

domain, (semaphorin) 4B, Sema4b

1382158_at

zinc finger protein 202, Zfp202

1379450_at

CTTNBP2 N-terminal like (predicted),

Cttnbp2nl_predicted

1373831_at

hypothetical protein LOC619574, LOC619574

1377439_at

similar to hypothetical protein FLJ13231 (predicted) ///

hypothetical protein LOC679830, LOC679830 ///

RGD1310081_predicted

1388583_at

chemokine (C-X-C motif) ligand 12, Cxcl12

1372473_at

tight junction protein 1 (predicted), Tjp1_predicted

1376440_at

ring finger protein 139 (predicted), Rnf139_predicted

1382873_at

CTTNBP2 N-terminal like (predicted),

Cttnbp2nl_predicted

1373830_at

hypothetical protein LOC619574, LOC619574

1396262_at

pre-B-cell colony enhancing factor 1, Pbef1

1372106_at

EH-domain containing 4, Ehd4

1376082_at

ecotropic viral integration site 1 (predicted), Evil_predicted

1390036_at

solute carrier family 16 (monocarboxylic acid transporters),

member 6, Slc16a6

1372270_at

dolichyl-phosphate (UDP-N-acetylglucosamine) N-

acetylglucosaminephosphotransferase 1 (GlcNAc-1-P

transferase), Dpagt1

1393234_at

Transcribed locus, strongly similar to NP_001106215.1

Rho guanine nucleotide exchange factor (GEF) 16 [ Mus

musculus ], —

1379287_at

cylindromatosis (turban tumor syndrome), Cyld

1372695_at

Transcribed locus, strongly similar to NP_081678.1 fibro-

nectin type III domain containing 5 [ Mus musculus ], —

1382277_at

lymphocyte antigen 96, Ly96

1387265_at

diacylglycerol kinase, gamma, Dgkg

1373669_at

glucosamine-6-phosphate deaminase 2 (predicted),

Gnpda2_predicted

1375216_at

poliovirus receptor-related 2, Pvrl2

1372846_at

cytochrome b, ascorbate dependent 3, Cybasc3

1379561_at

ATPase family, AAA domain containing 1, Atad1

1375177_at

Kruppel-like factor 13, Klf13

1395248_at

ER degradation enhancer, mannosidase alpha-like 1,

Edem1

1383829_at

bobby sox homolog ( Drosophila ) (predicted),

Bbx_predicted

1372895_at

similar to RIKEN cDNA 5730469M10, RGD1309676

1380650_at

TRIO and F-actin binding protein, Triobp

1393641_at

B-cell linker, Blnk

1367758_at

alpha-fetoprotein, Afp

1399167_a_at

growth factor receptor bound protein 2-associated protein 1

(predicted), Gab1_predicted

1368274_at

drebrin-like, Dbnl

1389059_at

Transcribed locus, weakly similar to XP_001250613.1

PREDICTED: hypothetical protein [ Bos taurus ], —

1385411_at

ubiquitin specific protease 43, rCG_32844

1384186_at

ER degradation enhancer, mannosidase alpha-like 1,

Edem1

1371624_at

zinc finger CCCH-type containing 7B (predicted),

Zc3h7b_predicted

1375934_at

ring finger protein 128 /// hypothetical protein LOC680663,

LOC680663 /// Rnf128

1389681_at

Transcribed locus, moderately similar to NP_002847.1

poliovirus receptor related 2 isoform alpha precursor

[ Homo sapiens ], —

1389164_at

hect domain and RLD 3 (predicted), Herc3_predicted

1375582_at

zinc finger homeodomain 4 (predicted), Zfhx4_predicted

1376766_at

formin-like 1 (predicted), Fmnl1_predicted

1386346_at

transmembrane protein 19, Tmem19

1388195_at

CUG triplet repeat, RNA binding protein 2, Cugbp2

1383554_at

ring finger protein 128 /// hypothetical protein LOC680663,

LOC680663 /// Rnf128

1391211_at

Atpase, class VI, type 11C (predicted), Atp11c_predicted

1388071_x_at

RT1 class Ib, locus Aw2, RT1-Aw2

1383662_at

hypothetical protein LOC500956, LOC500956

1388791_at

similar to 2810022L02Rik protein, RGD1309930

1387180_at

interleukin 1 receptor, type II, Il1r2

1373136_at

zinc finger with UFM1-specific peptidase domain, Zufsp

1373913_at

polyribonucleotide nucleotidyltransferase 1, Pnpt1

1369562_at

hippocalcin-like 1, Hpcal1

1371662_at

lysyl-tRNA synthetase, Kars

1392658_at

Similar to transcription elongation factor A 1 isoform 2,

LOC498453

1370972_x_at

RT1 class I, CE5, RT1-CE5

1388409_at

zinc finger CCCH-type containing 7B (predicted),

Zc3h7b_predicted

1372090_at

Max protein, Max

1392958_at

cylindromatosis (turban tumor syndrome), Cyld

1369557_at

caspase 7, Casp7

1376117_at

solute carrier family 44, member 4, Slc44a4

1372533_at

ER degradation enhancer, mannosidase alpha-like 1,

Edem1

1394842_at

transmembrane protein 19, Tmem19

1399153_at

RABSB, member RAS oncogene family (predicted),

Rab5b_predicted

1369197_at

apoptotic peptidase activating factor 1, Apaf1

1391679_at

hypothetical protein LOC691083, LOC691083

1375955_at

zinc finger protein 313, Zfp313

1383551_at

2,3-bisphosphoglycerate mutase, Bpgm

1373501_at

NIMA (never in mitosis gene a)-related expressed kinase 7,

Nek7

1398983_at

mitochondrial ribosomal protein L30 (predicted),

Mrpl30_predicted

1389387_at

similar to Proteasome inhibitor PI31 subunit,

LOC682071 /// LOC689852

1373065_at

protein tyrosine phosphatase, non-receptor type 18, Ptpn18

1377000_at

WAS protein homology region 2 domain containing 1,

Whdc1

1379256_at

similar to RIKEN cDNA 1810030O07 (predicted),

RGD1565685_predicted

1374400_at

EFR3 homolog A ( S. cerevisiae ), Efr3a

1373520_at

CDNA clone IMAGE: 7367270, —

1372865_at

zinc finger protein 364 (predicted), Zfp364_predicted

1392978_at

solute carrier family 25, member 28, Slc25a28

1372211_at

v-maf musculoaponeurotic fibrosarcoma oncogene family,

protein K (avian), Mafk

1379957_at

schlafen 8, Slfn8

1371774_at

spermidine/spermine N1-acetyl transferase 1, Sat1

1369067_at

nuclear receptor subfamily 4, group A, member 3, Nr4a3

1387131_at

serine (or cysteine) peptidase inhibitor, clade I, member 1,

Serpini1

1375853_at

Similar to CG13957-PA (predicted),

RGD1309995_predicted

1377970_at

poly (ADP-ribose) polymerase family, member 8, Parp8

1388823_at

RAB5B, member RAS oncogene family (predicted),

Rab5b_predicted

1389053_at

Similar to hypothetical protein FLJ20627 (predicted),

RGD1309546_predicted

1371525_at

solute carrier family 12, member 7, Slc12a7

1367710_at

proteasome (prosome, macropain) 28 subunit, beta, Psme2

1391442_at

EH-domain containing 3, Ehd3

1392838_at

similar to CG13957-PA (predicted),

RGD1309995_predicted

1387897_at

2′,3′-cyclic nucleotide 3′ phosphodiesterase, Cnp

1376835_at

Solute carrier family 35, member B2, Slc35b2

1380121_at

NIMA (never in mitosis gene a)-related expressed kinase 7,

Nek7

1388768_at

small G protein signaling modulator 2, Sgsm2

1368476_at

nuclear receptor subfamily 3, group C, member 2, Nr3c2

1367746_a_at

flotillin 2, Flot2

1370946_at

nuclear factor I/X, Nfix

1393389_at

nuclear receptor subfamily 4, group A, member 3, Nr4a3

1368273_at

mitogen-activated protein kinase 6, Mapk6

1388544_at

2,3-bisphosphoglycerate mutase, Bpgm

1375447_at

GTP binding protein 1 (predicted), Gtpbp1_predicted

1399063_at

ZUBR1, Rbaf600

1388233_at

cytokine inducible SH2-containing protein, Cish

1367663_at

proteasome (prosome, macropain) 28 subunit, alpha, Psme1

1380001_at

pinin, Pnn

1390859_at

Nedd4 binding protein 1, N4bp1

1374939_at

cytoplasmic FMR1 interacting protein 2 (predicted),

Cyfip2_predicted

1395336_at

Similar to 2810022L02Rik protein, RGD1309930

1383768_at

ELAV (embryonic lethal, abnormal vision, Drosophila )-

like 2 (Hu antigen B), Elavl2

1368813_at

CCAAT/enhancer binding protein (C/EBP), delta, Cebpd

1376810_at

M-phase phosphoprotein 8 /// poly (ADP-ribose)

polymerase family, member 4, Mphosph8 /// Parp4

1369559_a_at

CD47 antigen (Rh-related antigen, integrin-associated

signal transducer), Cd47

1386922_at

carbonic anhydrase 2, Ca2

1383616_at

interleukin 10 receptor, beta, Il10rb

1368248_at

CDP-diacylglycerol synthase 1, Cds1

1368158_at

sec1 family domain containing 1, Scfd1

1369654_at

protein kinase, AMP-activated, alpha 2 catalytic subunit,

Prkaa2

1392077_at

putative C11orf8 homolog (human), C11orf8h

1376692_at

homeodomain interacting protein kinase 2 (predicted),

Hipk2_predicted

1372179_at

hippocalcin-like 1, Hpcal1

1369590_a_at

DNA-damage inducible transcript 3, Ddit3

1372101_at

phosphatidic acid phosphatase type 2B, Ppap2b

1380867_a_at

pleckstrin homology domain containing, family M (with

RUN domain) member 1, Plekhm1

1371509_at

transforming growth factor beta regulated gene 1, Tbrg1

1375677_at

transducer of ERBB2, 2, Tob2

1391222_at

Nedd4 binding protein 1, N4bp1

1383369_at

tripartite motif-containing 26, Trim26

1367986_at

prostaglandin F2 receptor negative regulator, Ptgfrn

1393359_at

adaptor-related protein complex 3, beta 2 subunit

(predicted), Ap3b2_predicted

1371925_at

ATPase type 13A1 (predicted), Atp13a1_predicted

1373091_at

pleiomorphic adenoma gene-like 2 (predicted),

Plagl2_predicted

1368503_at

GTP cyclohydrolase 1, Gch1

1367733_at

carbonic anhydrase 2, Ca2

1384244_at

hydroxysteroid dehydrogenase like 2, Hsdl2

1389282_at

Integrin alpha 3 (predicted), Itga3_predicted

1380964_at

dystrobrevin alpha (predicted), Dtna_predicted

1393253_at

zinc finger protein 365, Zfp365

1388798_at

ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog,

yeast), Ube2e2

1392107_at

strawberry notch homolog 2 ( Drosophila ), Sbno2

1386976_at

CD82 antigen, Cd82

1376737_at

hypothetical protein LOC690243, LOC690243

1372009_at

tyrosyl-tRNA synthetase, Yars

1399161_a_at

type 1 tumor necrosis factor receptor shedding

aminopeptidase regulator, Arts1

1380582_at

colony stimulating factor 1 (macrophage), Csf1

1378293_at

tripartite motif-containing 26, Trim26

1395426_at

ubiquitin-conjugating enzyme E2 variant 1 (predicted),

Ube2v1_predicted

1377759_at

BH3 interacting domain death agonist, Bid

1383679_at

ring finger protein 31 (predicted), Rnf31_predicted

1368716_at

protein phosphatase 1, regulatory (inhibitor) subunit 14c,

Ppp1r14c

1392518_at

Similar to Protein C22orf5, RGD1306591

1386926_at

acyl-CoA synthetase long-chain family member 5, Acsl5

1375006_at

CDNA clone IMAGE: 7318427, —

1389913_at

leucine rich repeat (in FLII) interacting protein 1, Lrrfip1

1373588_at

FERM domain containing 8, Frmd8

1382710_at

Ectodermal-neural cortex 1, Enc1

1371550_at

TSC22 domain family, member 4, Tsc22d4

1368679_a_at

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog,

Lyn

1389331_at

CDNA clone IMAGE: 7313169, —

1381570_at

T-cell activation NFKB-like protein, Ta-nfkbh

1367696_at

interferon induced transmembrane protein 2, Ifitm2

1396278_at

sorting nexin 11, Snx11

1393703_at

human immunodeficiency virus type I enhancer binding

protein 3 (predicted), Hivep3_predicted

1379460_at

SH3-domain GRB2-like (endophilin) interacting protein 1,

Sgip1

1371005_at

ATP-binding cassette, sub-family C (CFTR/MRP), member

1, Abcc1

1368928_at

tripartite motif-containing 3, Trim3

1371531_at

similar to mammalian retrotransposon derived 8b,

LOC678880

1368674_at

liver glycogen phosphorylase, Pygl

1368896_at

MAD homolog 7 ( Drosophila ), Smad7

1387221_at

GTP cyclohydrolase 1, Gch1

1385361_at

ATPase, class V, type 10A, Atp10a

1376174_at

serine (or cysteine) peptidase inhibitor, clade A (alpha-1

antiproteinase, antitrypsin), member 11, Serpina11

1390423_at

MYC binding protein 2, Mycbp2

1372869_at

similar to isopentenyl diphosphate delta-isomerase type 2

(predicted) /// similar to Nucleolar GTP-binding protein 1

(Chronic renal failure gene protein) (GTP-binding protein

NGB), LOC689842 /// RGD1560805_predicted

1391897_at

RAB GTPase activating protein 1-like, Rabgap11

1371825_at

small nuclear RNA activating complex, polypeptide 2,

Snapc2

1382775_at

ryanodine receptor 2, cardiac, Ryr2

1385758_at

SAPS domain family, member 1 (predicted),

Saps1_predicted

1382029_at

similar to CDNA sequence BC017647 (predicted),

RGD1566149_predicted

1371528_at

FK506 binding protein 8, Fkbp8

1367938_at

UDP-glucose dehydrogenase, Ugdh

1371659_at

ras homolog gene family, member C (predicted),

Rhoc_predicted

1371731_at

Similar to Coatomer gamma-2 subunit (Gamma-2 coat pro-

tein) (Gamma-2 COP) (predicted), RGD1566215_predicted

1373748_at

PDZ domain containing RING finger 3 (predicted),

Pdzrn3_predicted

1374035_at

rad and gem related GTP binding protein 2, Rem2

1368983_at

heparin-binding EGF-like growth factor, Hbegf

1375861_at

nucleosome assembly protein 1-like 5, Nap1l5

1394022_at

inhibitor of DNA binding 4, Id4

1370606_at

purinergic receptor P2Y, G-protein coupled 1, P2ry1

1368641_at

wingless-related MMTV integration site 4, Wnt4

1382351_at

GTP binding protein (gene overexpressed in skeletal

muscle) (predicted), Gem_predicted

1368998_at

NK6 transcription factor related, locus 1 ( Drosophila ),

Nkx6-1

1375120_at

inhibitor of DNA binding 4, Id4

1384262_at

protein phosphatase 1, regulatory (inhibitor) subunit 3B,

Ppp1r3b

1384448_at

similar to RIKEN cDNA 1700045I19 (predicted),

RGD1565844_predicted

1371091_at

insulin receptor substrate 2, Irs2

1378899_at

solute carrier family 35, member D3 (predicted),

Slc35d3_predicted

1392590_at

Rho GTPase activating protein 24, Arhgap24

1376901_a_at

Similar to Hypothetical protein 6330514E13 (predicted),

RGD1559693_predicted

1367948_a_at

kinase insert domain protein receptor, Kdr

1378925_at

cAMP responsive element modulator, Crem

1379419_at

transmembrane protein 34, Tmem34

1372308_at

CDNA clone IMAGE: 7366335, —

1379724_at

pleckstrin homology-like domain, family B, member 2,

Phldb2

1390403_at

family with sequence similarity 43, member A, Fam43a

1393550_at

cAMP responsive element modulator, Crem

1382312_at

AT rich interactive domain 5B (Mrf1 like) (predicted),

Arid5b_predicted

1367977_at

synuclein, alpha, Snca

1388108_at

ELOVL family member 6, elongation of long chain fatty

acids (yeast), Elovl6

1390148_a_at

zinc finger protein 395 (predicted), Zfp395_predicted

1369737_at

cAMP responsive element modulator, Crem

1370478_at

myosin XVI, Myo16

1390127_at

DIX domain containing 1, Dixdc1

1392183_at

homeobox C9, Hoxc9

1373786_at

zinc finger protein 703, Zfp703

1369770_at

somatostatin receptor 1, Sstr1

1370942_at

RAS p21 protein activator 3, Rasa3

1397587_at

Histone deacetylase 5, Hdac5

1387455_a_at

very low density lipoprotein receptor, Vldlr

1376265_at

six transmembrane epithelial antigen of the prostate 2,

Steap2

1387947_at

v-maf musculoaponeurotic fibrosarcoma oncogene family,

protein B (avian), Mafb

1385374_at

Transcribed locus, strongly similar to NP_062067.2

thyrotroph embryonic factor [ Rattus norvegicus ], —

1397729_x_at

similar to RIKEN cDNA 1600029D21, LOC363060

1381605_at

ubiquitin specific protease 13 (isopeptidase T-3)

(predicted), Usp13_predicted

1369564_at

rad and gem related GTP binding protein 2, Rem2

1387477_at

potassium channel, subfamily K, member 12, Kcnk12

1395223_at

kelch domain containing 8B, Klhdc8b

1372548_at

Transcribed locus, strongly similar to NP_066940.1

cryptochrome 2 (photolyase-like) [ Homo sapiens ], —

1385387_at

NK2 transcription factor related, locus 2 ( Drosophila )

(predicted), Nkx2-2_predicted

1385491_at

PNMA-like 2, Pnmal2

1367805_at

glutaminase, Gls

1374594_at

similar to RIKEN cDNA 1600029D21, LOC363060

1373179_at

similar to H43E16.1, LOC689994

1370474_at

thyroid hormone receptor beta, Thrb

1367627_at

glycine amidinotransferase (L-arginine:glycine

amidinotransferase), Gatm

1383721_at

frizzled homolog 8 ( Drosophila ), Fzd8

1375043_at

FBJ osteosarcoma oncogene, Fos

1389611_at

very low density lipoprotein receptor, Vldlr

1393691_at

hypothetical protein LOC688273, LOC688273

1377404_at

stanniocalcin 1, Stc1

1379863_at

potassium voltage gated channel, Shal-related family,

member 2, Kcnd2

1368782_at

somatostatin receptor 2, Sstr2

1391117_at

PNMA-like 2, Pnmal2

1387968_at

solute carrier family 6 (neurotransmitter transporter),

member 15, Slc6a15

1392663_at

similar to hypothetical protein FLJ13188 (predicted),

RGD1305500_predicted

1370058_at

neurofilament, light polypeptide, Nefl

1388395_at

G0/G1 switch gene 2, G0s2

1377940_at

family with sequence similarity 101, member B, Fam101b

1369098_at

very low density lipoprotein receptor, Vldlr

1387370_at

tropomodulin 1, Tmod1

1385663_at

ubiquitin specific protease 13 (isopeptidase T-3)

(predicted), Usp13_predicted

1370111_at

potassium intermediate/small conductance calcium-

activated channel, subfamily N, member 2, Kcnn2

1382924_at

pantothenate kinase 1 (predicted), Pank1_predicted

1367857_at

fatty acid desaturase 1, Fads1

1381190_at

LIM domain only protein 7, LMO7

1373336_at

G protein-coupled receptor, family C, group 5, member B

(predicted), Gprc5b_predicted

1369752_a_at

calcium/calmodulin-dependent protein kinase IV, Camk4

1390339_at

Ubiquitin specific protease 13 (isopeptidase T-3)

(predicted), Usp13_predicted

1383390_at

family with sequence similarity 123A, Fam123a

1383826_at

Rab40b, member RAS oncogene family (predicted),

Rab40b_predicted

1379374_at

plasticity related gene 1, Lppr4

1385555_at

family with sequence similarity 101, member A, Fam101a

1398431_at

carbonic anhydrase 8, Car8

1387212_at

basic helix-loop-helix domain containing, class B, 8,

Bhlhb8

1389911_at

meteorin, glial cell differentiation regulator-like, Metrnl

1393615_at

similar to DEP domain containing 6 (predicted),

RGD1561030_predicted

1398732_at

hypothetical protein LOC688273, LOC688273

1387599_a_at

NAD(P)H dehydrogenase, quinone 1, Nqo1

1374906_at

ring finger protein 113A1, Rnf113a1

1374354_at

PHD finger protein 19 (predicted), Phf19_predicted

1372754_at

adaptor protein, phosphotyrosine interaction, PH domain

and leucine zipper containing 2, Appl2

1384415_at

SRY-box containing gene 7 (predicted), Sox7_predicted

1379626_at

Special AT-rich sequence binding protein 1, Satb1

1373985_at

Similar to KIAA1183 protein (predicted),

RGD1560435_predicted

1373108_at

protein phosphatase 1, regulatory (inhibitor) subunit 3C,

Ppp1r3c

1375726_at

LIM domain only 7, Lmo7

1384869_at

abhydrolase domain containing 7 (predicted),

Abhd7_predicted

1390097_at

TSPY-like 4, Tspyl4

1369792_at

G protein-coupled receptor 6, Gpr6

1369753_at

calcium/calmodulin-dependent protein kinase IV, Camk4

1390443_at

similar to DNA segment, Chr 16, ERATO Doi 472,

expressed (predicted), RGD1563888_predicted

1369095_at

protein phosphatase 1, regulatory (inhibitor) subunit 9A,

Ppp1r9a

1376649_at

SNF1-like kinase 2 (predicted), Snf1lk2_predicted

1376687_at

ubiquitin specific peptdiase 1, Usp1

1369738_s_at

cAMP responsive element modulator, Crem

1389514_at

leucine rich repeat and Ig domain containing 1, Lingo1

1380305_at

NOD3-like protein, nod3l

1387349_at

short stature homeobox 2, Shox2

1370317_at

asparagine-linked glycosylation 10 homolog B (yeast,

alpha-1,2-glucosyltransferase), Alg10b

1388078_a_at

amiloride-sensitive cation channel 2, neuronal, Accn2

1393952_at

coiled-coil domain containing 68, Ccdc68

1391601_at

leucine rich repeat protein 2, neuronal (predicted),

Lrrn2_predicted

1385036_at

synuclein, alpha interacting protein (synphilin) (predicted),

Sncaip_predicted

1383573_at

teashirt zinc finger family member 1, Tshz1

1376958_at

Similar to serine (or cysteine) proteinase inhibitor, clade B,

member 9 (predicted), RGD1562844_predicted

1372447_at

Fibroblast growth factor receptor 1, Fgfr1

1385636_at

frizzled homolog 3 ( Drosophila ), Fzd3

1370122_at

RAB27B, member RAS oncogene family, Rab27b

1371045_at

amiloride-sensitive cation channel 2, neuronal, Accn2

1377506_at

LAG1 homolog, ceramide synthase 1 /// growth differentia-

tion factor 1 (predicted), Gdf1_predicted /// Lass1

1379292_at

Similar to 5730420B22Rik protein (predicted),

RGD1306755_predicted

1372457_at

mitochondrial tumor suppressor 1, Mtus1

1374706_at

Growth differentiation factor 11, Gdf11

1379703_at

DENN/MADD domain containing 3, Dennd3

1383483_at

RAB9B, member RAS oncogene family (predicted),

Rab9b_predicted

1382868_at

sema domain, transmembrane domain (TM), and cyto-

plasmic domain, (semaphorin) 6A (predicted),

Sema6a_predicted

1368825_at

short stature homeobox 2, Shox2

1369954_at

isocitrate dehydrogenase 1 (NADP+), soluble, Idh1

1388718_at

tropomodulin 1, Tmod1

1370218_at

lactate dehydrogenase B, Ldhb

1393307_at

Phosphatase and actin regulator 3, Phactr3

1372365_at

Ras and Rab interactor 2 (predicted), Rin2_predicted

1386960_at

solute carrier family 37 (glucose-6-phosphate transporter),

member 4, Slc37a4

1372117_at

myotubularin related protein 10, Mtmr10

1383443_at

similar to UPF0308 protein C9orf21, LOC498685

1374236_at

leucine-rich repeat LGI family, member 2 (predicted),

Lgi2_predicted

1391194_at

Sal-like 1 ( Drosophila ) (predicted), Sall1_predicted

1398606_at

golgi integral membrane protein 4, Golim4

1390289_at

FIG4 homolog ( S. cerevisiae ), Fig4

1371421_at

similar to 3-oxoacid CoA transferase 1, LOC678860

1379257_at

erythrocyte protein band 4.1-like 4a (predicted),

Epb4.1l4a_predicted

1370941_at

platelet derived growth factor receptor, alpha polypeptide,

Pdgfra

1392739_a_at

endonuclease/exonuclease/phosphatase family domain

containing 1, Eepd1

1376187_at

Solute carrier family 35 (UDP-glucuronic acid/UDP-N-

acetylgalactosamine dual transporter), member D1

(predicted), Slc35d1_predicted

1397267_at

RIM binding protein 2, Rimbp2

1384009_at

nuclear prelamin A recognition factor, Narf

1384238_at

tweety homolog 2 ( Drosophila ), Ttyh2

1385175_at

homeo box B13 (predicted), Hoxb13_predicted

1389054_at

similar to RIKEN cDNA 0610040J01, LOC498368

1396492_at

Nfat activating molecule with ITAM motif 1, Nfam1

1375909_at

similar to glutathione transferase GSTM7-7, MGC108896

1392040_at

spindle assembly 6 homolog ( C. elegans ) (predicted),

Sass6_predicted

1375353_at

Cdk5 and Abl enzyme substrate 1 (predicted),

Cables1_predicted

1390993_at

phenazine biosynthesis-like protein domain containing,

Pbld

1372069_at

ankyrin repeat domain 15, Ankrd15

1389787_at

PTK7 protein tyrosine kinase 7 (predicted), Ptk7_predicted

1390168_a_at

DPH4 homolog (JJJ3, S. cerevisiae ), Dph4

1397861_at

V-set and transmembrane domain containing 2B, Vstm2b

1368160_at

insulin-like growth factor binding protein 1, Igfbp1

1382478_at

BTB (POZ) domain containing 3 (predicted),

Btbd3_predicted

1389003_at

Rho-related BTB domain containing 3 (predicted),

Rhobtb3_predicted

1370407_at

prenylcysteine oxidase 1, Pcyox1

1384331_at

sulfiredoxin 1 homolog ( S. cerevisiae ), Srxn1

1392789_at

solute carrier family 25, member 36, Slc25a36

1390481_a_at

ubiquitin-conjugating enzyme E2T (putative) (predicted),

Ube2t_predicted

1377599_at

lipin 1, Lpin1

1369686_at

doublecortin-like kinase 1, Dclk1

1370106_at

fibroblast growth factor 18, Fgf18

1390050_at

similar to Golgi phosphoprotein 2 (Golgi membrane protein

GP73), LOC680692 /// LOC682869

1390647_at

putative homeodomain transcription factor 2 (predicted),

Phtf2_predicted

1371131_a_at

thioredoxin interacting protein, Txnip

1388703_at

endothelial cell adhesion molecule, Esam

1381969_at

similar to Recombining binding protein suppressor of

hairless (J kappa-recombination signal binding protein)

(RBP-J kappa), LOC679028

1379541_at

transmembrane and tetratricopeptide repeat containing 4,

Tmtc4

1373398_at

Tripartite motif protein 37 (predicted), Trim37_predicted

1367806_at

glutaminase, Gls

1388973_at

procollagen, type IX, alpha 1, Col9a1

1385321_at

similar to Protein arginine N-methyltransferase 4

(Heterogeneous nuclear ribonucleoprotein

methyltransferase-like protein 4), LOC688502

1370416_at

Max dimerization protein 3, Mxd3

1376873_at

cerebellin 1, Cbln1

1375423_at

hypothetical protein LOC689959, LOC689959

1373291_at

deleted in liver cancer 1, Dlc1

1377729_at

elongation of very long chain fatty acids (FEN1/Elo2,

SUR4/Elo3, yeast)-like 4 (predicted), Elovl4_predicted

1392943_at

membrane bound O-acyltransferase domain containing 2,

Mboat2

1367899_at

coagulation factor II (thrombin) receptor, F2r

1389067_at

solute carrier organic anion transporter family, member

4a1, Slco4a1

1370158_at

myosin, heavy polypeptide 10, non-muscle, Myh10

1396112_at

myotubularin related protein 10, Mtmr10

1387503_at

carboxypeptidase N, polypeptide 1, Cpn1

1389632_at

Rho-related BTB domain containing 1 (predicted),

Rhobtb1_predicted

1386129_at

inhibitor of growth family, member 2, Ing2

1377669_at

RAB27A, member RAS oncogene family, Rab27a

1379817_at

purine-rich element binding protein G (predicted),

Purg_predicted

1379302_at

recombining binding protein suppressor of hairless

( Drosophila ) (predicted) /// similar to Recombining binding

protein suppressor of hairless (J kappa-recombination

signal binding protein) (RBP-J kappa), LOC679028 ///

Rbpsuh_predicted

1374333_at

similar to RIKEN cDNA 1110007C09 (predicted),

RGD1306058_predicted

1383433_at

kelch-like 23 ( Drosophila ) (predicted), Klhl23_predicted

1370059_at

neurofilament, light polypeptide, Nefl

1368174_at

EGL nine homolog 3 ( C. elegans ), Egln3

1391871_at

StAR-related lipid transfer (START) domain containing 13,

Stard13

1395160_at

proline-rich transmembrane protein 3, Prrt3

1367869_at

oxidation resistance 1, Oxr1

1381974_at

BTB (POZ) domain containing 3 (predicted),

Btbd3_predicted

1393101_at

F-box and leucine-rich repeat protein 10, Fbxl10

1374846_at

hexamethylene bis-acetamide inducible 1, Hexim1

1374748_at

serine hydroxymethyltransferase 1 (soluble), Shmt1

1375877_at

synaptotagmin IV, Syt4

1398296_at

glycerophosphodiester phosphodiesterase 1, Gde1

1371963_at

propionyl-coenzyme A carboxylase, alpha polypeptide,

Pcca

1398484_at

similar to TBC1 domain family, member 8 (with GRAM

domain); vascular Rab-GAP/TBC-containing (predicted),

RGD1308221_predicted

1391077_at

claspin homolog (Xenopus laevis) (predicted),

Clspn_predicted

1369735_at

growth arrest specific 6, Gas6

1390406_at

Rho GTPase activating protein 18 (predicted),

Arhgap18_predicted

1384516_at

Metal response element binding transcription factor 2, Mtf2

1370247_a_at

peripheral myelin protein 22, Pmp22

1387623_at

stanniocalcin 1, Stc1

1386577_at

kelch-like 23 ( Drosophila ) (predicted), Klhl23_predicted

1370237_at

hydroxyacyl-Coenzyme A dehydrogenase, Hadh

1385302_at

glycerophosphodiester phosphodiesterase domain

containing 1 (predicted), Gdpd1_predicted

1373959_at

protein phosphatase 2 (formerly 2A), regulatory subunit A

(PR 65), beta isoform, Ppp2r1b

1398398_at

homeo box A10, Hoxa10

1383601_at

CDNA clone MGC: 188768 IMAGE: 9101044, —

1370268_at

potassium voltage-gated channel, shaker-related subfamily,

member 5, Kcna5

1389549_at

proline synthetase co-transcribed (predicted),

Prosc_predicted

1374160_at

transmembrane and coiled-coil domains 2, Tmcc2

1374890_at

Transcribed locus, strongly similar to NP_005656.4

ecotropic viral integration site 5 [ Homo sapiens ], —

1390228_at

amine oxidase, flavin containing 1 (predicted),

Aof1_predicted

1378235_at

glycerophosphodiester phosphodiesterase domain

containing 1 (predicted), Gdpd1_predicted

1392406_at

IAP promoted placental gene (predicted), Ipp_predicted

1371983_at

Josephin domain containing 1, Josd1

1389791_at

ceroid-lipofuscinosis, neuronal 8, Cln8

1392165_at

inhibitor of growth family, member 2, Ing2

1387805_at

BCL2/adenovirus E1B 19 kDa-interacting protein 3, Bnip3

1374491_at

CKLF-like MARVEL transmembrane domain containing

8, Cmtm8

1387310_at

ATPase, Ca++ transporting, type 2C, member 2, Atp2c2

1384852_at

RAB27A, member RAS oncogene family, Rab27a

1368924_at

growth hormone receptor, Ghr

1368964_at

leucine rich repeat protein 3, neuronal, Lrrn3

1376213_at

similar to Rap2-binding protein 9, MGC124740

1369696_at

Ras-related GTP binding B, RragB

1373043_at

stromal cell-derived factor 2-like 1 (predicted),

Sdf2l1_predicted

1372782_a_at

adenosine monophosphate deaminase 2 (isoform L),

Ampd2

1383382_at

similar to jumonji protein, LOC681740

1390028_at

dual-specificity tyrosine-(Y)-phosphorylation regulated

kinase 2 (predicted), Dyrk2_predicted

1383326_a_at

programmed cell death 4, Pdcd4

1399005_at

protein phosphatase 2, regulatory subunit B (B56), alpha

isoform (predicted), Ppp2r5a_predicted

1389301_at

similar to muscleblind-like 2 isoform 1, LOC680445

1368440_at

solute carrier family 3, member 1, Slc3a1

1377869_at

CCR4 carbon catabolite repression 4-like B ( S. cerevisiae ),

Ccrn4lb

1372093_at

Max interacting protein 1, Mxi1

1370548_at

solute carrier family 16 (monocarboxylic acid transporters),

member 10, Slc16a10

1390249_at

septin 14, Sept14

1388919_at

zinc finger protein 541, Zfp541

1397173_at

similar to Serine/threonine-protein kinase WNK3 (Protein

kinase, lysine-deficient 3)

(predicted), RGD1563131_predicted

1382814_at

odd Oz/ten-m homolog 3 ( Drosophila ) (predicted),

Odz3_predicted

1373659_at

hypothetical protein LOC688257, LOC688257

1391906_at

cortistatin /// kinesin family member 1B, Cort /// Kif1b

1378430_at

monooxygenase, DBH-like 1, Moxd1

1373656_at

protein phosphatase 1, regulatory subunit 3D, Ppp1r3d

1376758_at

inhibitor of growth family, member 1, Ing1

1375059_at

zinc finger protein 652, Zfp652

1374957_at

similar to ribosomal protein L27a (predicted),

RGD1560633_predicted

1384877_at

aquaporin 11, Aqp11

1370054_at

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4),

Cdkn2c

1367755_at

cysteine dioxygenase 1, cytosolic, Cdo1

1383328_x_at

programmed cell death 4, Pdcd4

1379440_at

follistatin-like 3, Fstl3

1395623_at

glutaminyl-peptide cyclotransferase-like (predicted),

Qpctl_predicted

1370036_at

sulfite oxidase, Suox

1369670_at

Cd200 antigen, Cd200

1392953_at

protein tyrosine phosphatase-like (proline instead of

catalytic arginine), member a, Ptpla

1383534_at

Transcribed locus, moderately similar to XP_001479249.1

PREDICTED: similar to zinc finger protein 605 [ Mus

musculus ], —

1384885_at

tektin 2, Tekt2

1368122_at

ring finger protein 103, Rnf103

1373625_at

serine hydroxymethyltransferase 1 (soluble), Shmt1

1388856_at

kit ligand, Kitl

1367702_at

acyl-Coenzyme A dehydrogenase, medium chain, Acadm

1374625_at

hairy and enhancer of split 6 ( Drosophila ), Hes6

1369785_at

phosphoribosyl pyrophosphate amidotransferase, Ppat

1385829_at

obscurin-like 1, Obsl1

1383962_at

SIVA1, apoptosis-inducing factor, Siva1

1383666_at

peptidyl-tRNA hydrolase 1 homolog ( S. cerevisiae )

(predicted), Ptrh1_predicted

1373345_at

adhesion molecule with Ig like domain 2, Amigo2

1391919_at

transcription elongation regulator 1-like, Tcerg1l

1384392_at

cytochrome P450, family 26, subfamily b, polypeptide 1,

Cyp26b1

1374540_at

cell division cycle associated 7, Cdca7

1385503_at

similar to O-acetyltransferase, LOC678772

1393439_a_at

progressive ankylosis, Ank

1374030_at

similar to KIAA0999 protein, LOC684112

1377995_at

integrin alpha FG-GAP repeat containing 3, Itfg3

1393218_at

similar to 2410024A21Rik protein, RGD1304878

1383722_at

proline synthetase co-transcribed (predicted),

Prosc_predicted

1374235_at

regulator of calcineurin 2, Rcan2

1372248_at

sestrin 1 (predicted), Sesn1_predicted

1387670_at

glycerol-3-phosphate dehydrogenase 2, mitochondrial,

Gpd2

1387032_at

cholecystokinin, Cck

1395269_s_at

gamma-aminobutyric acid (GABA-A) receptor, subunit

delta, Gabrd

1387662_at

synaptotagmin IV, Syt4

1369010_at

CHK2 checkpoint homolog ( S. pombe ), Chek2

1393347_at

integrin alpha L, Itgal

1376963_at

dual-specificity tyrosine-(Y)-phosphorylation regulated

kinase 2 (predicted), Dyrk2_predicted

1371763_at

similar to RIKEN cDNA 4931406C07, RGD1309534

1386978_at

BCL2/adenovirus E1B interacting protein 3-like, Bnip3l

1370814_at

dehydrogenase/reductase (SDR family) member 4, Dhrs4

1369457_a_at

synaptotagmin-like 4, Sytl4

1367853_at

solute carrier family 12 (sodium/potassium/chloride

transporters), member 2, Slc12a2

1392079_at

A kinase (PRKA) anchor protein 7, Akap7

1395968_at

similar to Myosin-15 (Myosin XV) (Unconventional

myosin-15), LOC688264

1369412_a_at

solute carrier family 19 (sodium/hydrogen exchanger),

member 1, Slc19a1

1381515_at

CDNA clone IMAGE: 7123062, —

1370120_at

follistatin-like 3, Fstl3

1379258_at

kelch-like 5 ( Drosophila ), Klhl5

1373734_at

Solute carrier organic anion transporter family, member

3a1, Slco3a1

1389084_at

Transcribed locus, weakly similar to XP_001480799.1

PREDICTED: hypothetical protein [ Mus musculus ], —

1393109_at

CDNA clone IMAGE: 7302574, —

1373480_at

heat shock 70 kDa protein 12A (predicted),

Hspa12a_predicted

1367791_at

receptor (calcitonin) activity modifying protein 1, Ramp1

1396317_at

cell cycle progression 1 (predicted), Ccpg1_predicted

1387521_at

programmed cell death 4, Pdcd4

1374976_a_at

Sterol O-acyltransferase 1, Soat1

1384210_at

MICAL C-terminal like, Micalcl

1369000_at

neurotrophic tyrosine kinase, receptor, type 1, Ntrk1

1389876_at

Calcium/calmodulin-dependent protein kinase II inhibitor

1, Camk2n1

1371679_at

synaptopodin 2, Synpo2

1383444_at

solute carrier family 24 (sodium/potassium/calcium

exchanger), member 2, Slc24a2

1379108_at

Similar to ADP-ribosylation factor guanine nucleotide

factor 6 isoform a (predicted), RGD1559968_predicted

1387271_at

phytanoyl-CoA hydroxylase, Phyh

1390207_at

large tumor suppressor 2 (predicted), Lats2_predicted

1368514_at

monoamine oxidase B, Maob

1393196_at

kelch-like 23 ( Drosophila ) (predicted), Klhl23_predicted

1379608_at

RGD1560010 (predicted), RGD1560010_predicted

1388958_a_at

solute carrier family 2 (facilitated glucose transporter),

member 4, Slc2a4

1383300_at

kelch-like 24 ( Drosophila ), Klhl24

1374557_at

G protein-coupled receptor 177, Gpr177

1371113_a_at

transferrin receptor, Tfrc

1393848_at

ribonucleotide reductase M2, Rrm2

comprising the step of administering a compound according to claim 1 to a patient in need thereof.

33. The method according to claim 32 , wherein said disease or disorder is a cell proliferative disorder.

34. A compound of Formula II:

wherein e is 0, 1, 2, 3 or 4;

R 50 is —C(O)R 54 , —C(O)N(H)R 54 , —C(S)R 54 , —C(S)N(H)R 54 ;

wherein R 54 is alkyl or substituted alkyl, —(CH 2 ) 2 O(CH 2 CH 2 O) f CH 2 CH 2 NH 2 , —(CH 2 ) 2 —O—(CH 2 CH 2 ) g NH 2 , —(CH 2 CH 2 ) g NH 2 , —(CH 2 ) 2 —O—(CH 2 CH 2 O) f CH 2 CH 2 SH, —(CH 2 ) 2 —O—(CH 2 CH 2 ) g SH, —(CH 2 CH 2 ) g OH, —(CH 2 ) 2 —O—(CH 2 CH 2 O) f CH 2 CH 2 OH, —(CH 2 ) 2 —O—(CH 2 CH 2 ) g OH, —(CH 2 CH 2 ) g OH;

wherein each f and g is independently, an integer between 0 and 500, preferably, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 17;

each R 51 , R 52 and R 53 is independently hydrogen, halogen, —OR 10 , —SR 10 , —NR 10 R 11 , —C(O)R 10 , —C(O)OR 10 , —C(O)NR 10 R 11 , —N(R 10 )C(O)R 11 , —CF 3 , —CN, —NO 2 , —N 3 , acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl.