Methods and compositions for the treatment of cancer or other diseases
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.
1. A chimeric molecule comprising a human STAT3 sense strand and a human CpG(D19)-STAT3 antisense strand, wherein the human STAT3 sense strand comprises an oligonucleotide having nucleotides set forth in SEQ ID NO:4, wherein the human CpG(D19)-STAT3 antisense strand comprises (a) a first oligonucleotide having the nucleotides set forth in SEQ ID NO:16, (b) a C3 carbon chain or propanediol linker and (c) a second oligonucleotide having the nucleotides set forth in SEQ ID NO:5 that is the antisense strand, and wherein the sense strand and the antisense strand anneal to form a double stranded siRNA.
2. A method of treating a disease which comprises administering a therapeutically effective amount of the molecule of claim 1 to an individual in need thereof, wherein the disease is one that can be treated by regulating the Stat3 pathway or genes under control of Stat3.
3. The method of claim 2 , wherein the disease is selected from the group consisting of cancer, an infectious disease and an autoimmune disease.